In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
Abstract
:1. Introduction
2. Results
2.1. Chemistry
2.2. In-Vitro Anticancer Evaluation
3. Experimental Section
3.1. General Information
3.2. Chemistry: General Procedure for the Synthesis of Sulfonamide Derivatives 3–16
3.3. In-Vitro Anticancer Evaluation
3.3.1. Cell Culture
3.3.2. Cytotoxicity Assay
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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- Sample Availability: Not Available.
Sample Code | A549 (Lungs) | HeLa (Cervical) | LoVo (Colorectal) | MDA-MB-231 (Breast) |
---|---|---|---|---|
IC50(µM) ± SD (n = 3) | ||||
2 | NA | NA | NA | 446.1 ± 0.01 |
3 | NA | NA | NA | NA |
4 | NA | 259.6 ± 0.06 | NA | NA |
5 | NA | Na | NA | NA |
6 | 171.4 ± 0.32 | 137.5 ± 0.12 | 135.2 ± 0.01 | 121.9 ± 0.11 |
7 | NA | NA | 89.47 ± 0.09 | 283.9 ± 0.11 |
8 | NA | NA | NA | NA |
9 | 199.5 ± 0.12 | NA | NA | NA |
10 | 272.1 ± 0.07 | 149.3 ± 0.03 | 305.1 ± 1.00 | NA |
11 | NA | NA | NA | NA |
12 | NA | 150.9 ± 0.04 | NA | 163.2 ± 0.06 |
13 | NA | NA | NA | 267.3 ± 0.01 |
14 | NA | NA | NA | NA |
15 | NA | NA | NA | NA |
16 | NA | NA | 301.4 ± 1.00 | 134.4 ± 0.02 |
Doxorubicin | 283.5 ± 0.01 | 120.7 ± 0.09 | 374.4 ± 1.00 | 26.5 ± 0.54 |
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Ghorab, M.M.; Alsaid, M.S.; Al-Dosari, M.S.; El-Gazzar, M.G.; Arbab, A.H. In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives. Molecules 2016, 21, 409. https://doi.org/10.3390/molecules21040409
Ghorab MM, Alsaid MS, Al-Dosari MS, El-Gazzar MG, Arbab AH. In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives. Molecules. 2016; 21(4):409. https://doi.org/10.3390/molecules21040409
Chicago/Turabian StyleGhorab, Mostafa M., Mansour S. Alsaid, Mohammed S. Al-Dosari, Marwa G. El-Gazzar, and Ahmed H. Arbab. 2016. "In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives" Molecules 21, no. 4: 409. https://doi.org/10.3390/molecules21040409
APA StyleGhorab, M. M., Alsaid, M. S., Al-Dosari, M. S., El-Gazzar, M. G., & Arbab, A. H. (2016). In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives. Molecules, 21(4), 409. https://doi.org/10.3390/molecules21040409