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Review
Peer-Review Record

Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity

Int. J. Mol. Sci. 2020, 21(19), 7430; https://doi.org/10.3390/ijms21197430
by Shamshul Ansari 1 and Yoshio Yamaoka 2,3,4,5,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(19), 7430; https://doi.org/10.3390/ijms21197430
Submission received: 21 September 2020 / Revised: 6 October 2020 / Accepted: 6 October 2020 / Published: 8 October 2020
(This article belongs to the Special Issue Microbial Virulence Factors 2.0)

Round 1

Reviewer 1 Report

A very good review of the cytotoxin-associated protein H. pylori - CagA. I have no fundamental remarks

Author Response

Thank you very much for your positive comments.

Reviewer 2 Report

The manuscript is quite well written.

It represents a comprehensive review of the field.

The authors discuss the possible role of CagA in gastric pathogenicity.

Several virulence factors, including cytotoxin-associated gene A (CagA), which

is translocated into the gastric epithelium via the type 4 secretory system

(T4SS), have been indicated to play a crucial role in disease development.

Although infection with strains harboring the East Asian type of CagA

possessing the EPIYA-A, B, and -D sequences has been found to potentiate cell

proliferation and disease pathogenicity, the exact mechanism of CagA

involvement in disease severity still remains to be elucidated.  

It would be useful for the readers to include the discussion of

PMID:  9247587.

Author Response

Thank you very much for your positive comments.

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