Extracellular Matrix Derived from High Metastatic Human Breast Cancer Triggers Epithelial-Mesenchymal Transition in Epithelial Breast Cancer Cells through αvβ3 Integrin
, Edward Helal-Neto 1, Andreza Maia Vieira 2, Pedro Barcellos-de-Souza 3, Jose Morgado-Diaz 3 and Christina Barja-Fidalgo 1,*Round 1
Reviewer 1 Report
The study entitled “Extracellular matrix derived from high metastatic human breast cancer triggers epithelial mesenchymal transition in epithelial breast cancer cells through αvβ3 integrin” shows that ECM produced by a high metastatic breast cancer cell (MDA-MB 231) is able to induce epithelial-mesenchymal transition in a low-metastatic, epithelial breast cancer cell line (MCF-7) through avb3 integrin. The subject of the manuscript is interesting and the study appears well performed and the manuscript is well written and
organized. Personally, I think that the manuscript is suitable for publication and that ijms would be an appropriate place for it to be published.
Reviewer 2 Report
The authors have addressed the major concerns.
