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Review
Peer-Review Record

3D Bioprinting of Human Tissues: Biofabrication, Bioinks, and Bioreactors

Int. J. Mol. Sci. 2021, 22(8), 3971; https://doi.org/10.3390/ijms22083971
by Jianhua Zhang, Esther Wehrle, Marina Rubert and Ralph Müller *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(8), 3971; https://doi.org/10.3390/ijms22083971
Submission received: 2 April 2021 / Revised: 7 April 2021 / Accepted: 9 April 2021 / Published: 12 April 2021
(This article belongs to the Special Issue Future Trends in Biomaterials and Devices for Cells and Tissues)

Round 1

Reviewer 1 Report

This manuscript, written by Zhang et al., focuses on recent technological advances in 3D bioprinting of cell-laden scaffolds for human tissue engineering applications. Authors herein review the major bioprinting techniques (inkjet-based bioprinting, laser-assisted bioprinting, extrusion-based bioprinting), bioink formulation (inks, cell selection, growth factor selection), key bioink properties for 3D bioprinting of human tissues, and in vitro bioreactor systems for scaffold maturation (spinner flask bioreactor, rotating-wall vessel bioreactor, compression bioreactor, perfusion bioreactor). They also provide a summary of present limitations and future developments on the application of 3D bioprinting and bioreactor systems for engineering human tissues. The manuscript, in general, is well-written. I suggest the acceptance of this manuscript in its present form.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

See attached file.

Comments for author File: Comments.docx

Author Response

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Author Response File: Author Response.docx

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