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Volume 23
Issue 1
10.3390/ijms23010137
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Review
Peer-Review Record

The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells

Int. J. Mol. Sci. 2022, 23(1), 137; https://doi.org/10.3390/ijms23010137
by Tom J. Harryvan 1,*, Sabine de Lange 1, Lukas J.A.C. Hawinkels 1,*,† and Els M.E. Verdegaal 2,*,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2022, 23(1), 137; https://doi.org/10.3390/ijms23010137
Submission received: 30 November 2021 / Revised: 20 December 2021 / Accepted: 22 December 2021 / Published: 23 December 2021
(This article belongs to the Special Issue 25th Anniversary of IJMS: Advances in Biochemistry)

Round 1

Reviewer 1 Report

Authors should discuss/incorporate the below points in the manuscript

1. Authors should describe the role of non-professional antigen presenting cells in others diseases alongwith cancer.

2.Spell check is needed to correct the typo errors. e.g. MCH

3. How professional antigen presenting cells are superior over non-professional cells.

4. Can these non professional antigen presenting cell be modified to treat the diseases?

Author Response

Our point-to-point response to Reviewer 1 has been attached ('Reviewer 1 revision_final.docx').

Author Response File: Author Response.docx

Reviewer 2 Report

Harryvan et al. provide a survey over stromal cells being able to present antigens with and/or without co-stimulation. The former have a role in autoimmunity and possible antitumoral responses, the latter in thymus-independent tolerance due to the key mechanism of anergy. The review is comprehensively written, naming possible white spots and allowing to draw further hypotheses for further descriptive and mechanistic studies. I only have few minor points.

Minor issues:

  • Line 62: The content of quotes 6,7 (reviews) is already mentioned in citation 4 (Joffre et al).
  • Line 120: Here, “CAF” is mentioned for the first time (check together with line 169).
  • Line 121: “…MHCII[23], have been first identified in pancreatic ductal adenocarcinoma (PDAC).” -> …MHCII, have been first identified in pancreatic ductal adenocarcinoma (PDAC)[23].
  • Lines 179-189 and 190-192: Please briefly clarify where your data relies on in vivo, ex vivo and in vitro experiments.
  • Line 213: “…were show..” -> were shown.
  • Line 313: “…, potentiating cytotoxic T cell function.” Please add quote.
  • Line 402: “…antigens5.” Please check quote.

Author Response

Our point-to-point response to Reviewer 1 has been attached ('Reviewer 2 revision_final.docx').

Author Response File: Author Response.docx

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