Next Article in Journal
Development of an Oral Isoliquiritigenin Self-Nano-Emulsifying Drug Delivery System (ILQ-SNEDDS) for Effective Treatment of Eosinophilic Esophagitis Induced by Food Allergy
Previous Article in Journal
Gastrointestinal Permeation Enhancers for the Development of Oral Peptide Pharmaceuticals
Previous Article in Special Issue
Effects of Dexmedetomidine on Basic Cardiac Electrophysiology in Adults; a Descriptive Review and a Prospective Case Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceuticals
Volume 15
Issue 12
10.3390/ph15121586
Review Report
pharmaceuticals-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Andrographolide Relieves Post-Operative Wound Pain but Affects Local Angiogenesis

Pharmaceuticals 2022, 15(12), 1586; https://doi.org/10.3390/ph15121586
by Yi-Lo Lin 1, Jiunn-Wang Liao 1, Shunching Wang 2, Badrinathan Sridharan 2, Hsin-Ju Lee 2, Ai Li 2, Kai-Ming Chang 3, Ching-Yang Wu 4, Siendong Huang 5, Kai-Ting Chang 6, Dinesh Chandra Agrawal 2, Ching-Jung Chen 7 and Meng-Jen Lee 2,*
Reviewer 1: Anonymous
Reviewer 2:
Mohamed El Raey
Pharmaceuticals 2022, 15(12), 1586; https://doi.org/10.3390/ph15121586
Submission received: 13 July 2022 / Revised: 4 November 2022 / Accepted: 16 November 2022 / Published: 19 December 2022
(This article belongs to the Special Issue Drug Candidates for Anesthesia and Analgesia)

Round 1

Reviewer 1 Report

First of all, a significant concern is how the data was collected immediately after a few hours of surgery. The cites for allodynia measurements are also questionable. These are very close to the wounds. 

Secondly, the authors should use an infographic figure to explain their study design and treatment. It is complex and will not be easy for readers. 

Next, the conclusion and discussion are not adequate. They should expand these sections. 

Authors should mention whether they have any animal ethics number and cite it in the manuscript and if their experiments align with ARRIVE guidelines. How they handled their animals and conducted their experiments also needs better clarification.

There are many typographical errors, and the manuscript seems incomplete. Authors should pay attention to the formating and minimise the errors.

Finally, the number of references in the discussion is poor. They should cite relevant papers and discuss similar or conflicting studies. 

Author Response

please see the attachment 

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript discussed the effect of Andrographolide (Andro) on the reduction of pain sensation in a rat post-operative wound model . It was observed that Andro significantly reduced mechanical allodynia compared to saline-treatment, both in shorter and longer time frame. It influenced expression pERK and GluR1 in the dorsal horn, and the angiogenesis process in the wound healing area.

I accept the manuscript as its but after small changes.

Abstract: Line 20 the plant name Andrographis paniculat should be italic

Line 158 valuesincreased, distance should be added.

Author Response

please see the attachment 

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Authors have revised the manuscript and addressed comments.

Author Response

reviewer's comments: 

Authors have revised the manuscript and addressed comments.

My reply:

thank you very much for your comments. I have added a few alterations according to the academic editors comments to upgrad the figure legends.

Back to TopTop