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Review

Recent Advances in Pathogenic Streptococcus Vaccine Development

1
Department of Pathogenic Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China
2
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
*
Author to whom correspondence should be addressed.
Hongren Wang and Zhen Qin contributed equally to this work.
Curr. Issues Mol. Biol. 2019, 32(1), 645-700; https://doi.org/10.21775/cimb.032.645
Submission received: 9 March 2019 / Revised: 11 April 2019 / Accepted: 15 May 2019 / Published: 5 June 2019

Abstract

Streptococcus pneumoniae (Spn) and Streptococcus pyogenes (Spy) cause many invasive and noninvasive diseases responsible for high morbidity and mortality worldwide. Safe, efficacious and affordable vaccines could have a significant, positive impact on the global infectious disease burden. Since the implementation of pneumococcal vaccine in the 1980s, the incidence of Spn infection has decreased significantly. Still so, these currently used multivalent polysaccharides and conjugated pneumococcal vaccines have some limitations. For Spy, there are even no vaccines available yet. There is an urgent need of new vaccines against Spn and Spy. Encouragingly, with the hard work of many investigators worldwide, a number of new vaccines candidates are developed with promising results. Of them, many have already entered the clinical trial stage. This review will describe the current status of Spn and Spy vaccine development, with particular focus on protein-based strategy.
Keywords: recent; advances; pathogenic; Streptococcus; vaccine; development recent; advances; pathogenic; Streptococcus; vaccine; development

Share and Cite

MDPI and ACS Style

Wang, H.; Qin, Z.; Li, M. Recent Advances in Pathogenic Streptococcus Vaccine Development. Curr. Issues Mol. Biol. 2019, 32, 645-700. https://doi.org/10.21775/cimb.032.645

AMA Style

Wang H, Qin Z, Li M. Recent Advances in Pathogenic Streptococcus Vaccine Development. Current Issues in Molecular Biology. 2019; 32(1):645-700. https://doi.org/10.21775/cimb.032.645

Chicago/Turabian Style

Wang, Hongren, Zhen Qin, and Mingyuan Li. 2019. "Recent Advances in Pathogenic Streptococcus Vaccine Development" Current Issues in Molecular Biology 32, no. 1: 645-700. https://doi.org/10.21775/cimb.032.645

APA Style

Wang, H., Qin, Z., & Li, M. (2019). Recent Advances in Pathogenic Streptococcus Vaccine Development. Current Issues in Molecular Biology, 32(1), 645-700. https://doi.org/10.21775/cimb.032.645

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