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Volume 32
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10.21775/cimb.032.167
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

The VicRK Two-Component System Regulates Streptococcus mutans Virulence

by
Lei Lei
1,2,†,
Li Long
3,†,
Xin Yang
3,
Yang Qiu
3,
Yanglin Zeng
3,
Tao Hu
1,
Shida Wang
3,* and
Yuqing Li
3,*
1
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
2
Department of Microbiology, The Forsyth Institute, Cambridge, MA, USA
3
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
*
Authors to whom correspondence should be addressed.
†
Co-first author.
Curr. Issues Mol. Biol. 2019, 32(1), 167-200; https://doi.org/10.21775/cimb.032.167
Submission received: 12 March 2019 / Revised: 9 April 2019 / Accepted: 12 May 2019 / Published: 5 June 2019
Versions Notes

Abstract

Streptococcus mutans is considered the predominant etiological agent of dental caries with the ability to form biofilm on the tooth surface. And, its abilities to obtain nutrients and metabolize fermentable dietary carbohydrates to produce acids contribute to its pathogenicity. The responses of S. mutans to environmental stresses are essential for its survival and role in cariogenesis. The VicRK system is one of the 13 putative TCS of S. mutans. The conserved functions of the VicRK signal transduction system is the key regulator of bacterial oxidative stress responses, acidification, cell wall metabolism, and biofilm formation. In this paper, it was discussed how the VicRK system regulates S. mutans virulence including bacterial physiological function, operon structure, signal transduction, and even post-transcriptional control in its regulon. Thus, this emerging subspecialty of the VicRK regulatory networks in S. mutans may strengthen our understandings aimed at providing a basis for the prevention of dental caries.
Keywords: VicRK; two-component; system; regulates; streptococcus mutans; virulence VicRK; two-component; system; regulates; streptococcus mutans; virulence

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MDPI and ACS Style

Lei, L.; Long, L.; Yang, X.; Qiu, Y.; Zeng, Y.; Hu, T.; Wang, S.; Li, Y. The VicRK Two-Component System Regulates Streptococcus mutans Virulence. Curr. Issues Mol. Biol. 2019, 32, 167-200. https://doi.org/10.21775/cimb.032.167

AMA Style

Lei L, Long L, Yang X, Qiu Y, Zeng Y, Hu T, Wang S, Li Y. The VicRK Two-Component System Regulates Streptococcus mutans Virulence. Current Issues in Molecular Biology. 2019; 32(1):167-200. https://doi.org/10.21775/cimb.032.167

Chicago/Turabian Style

Lei, Lei, Li Long, Xin Yang, Yang Qiu, Yanglin Zeng, Tao Hu, Shida Wang, and Yuqing Li. 2019. "The VicRK Two-Component System Regulates Streptococcus mutans Virulence" Current Issues in Molecular Biology 32, no. 1: 167-200. https://doi.org/10.21775/cimb.032.167

APA Style

Lei, L., Long, L., Yang, X., Qiu, Y., Zeng, Y., Hu, T., Wang, S., & Li, Y. (2019). The VicRK Two-Component System Regulates Streptococcus mutans Virulence. Current Issues in Molecular Biology, 32(1), 167-200. https://doi.org/10.21775/cimb.032.167

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