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Volume 32
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10.21775/cimb.032.201
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

ComDE Two-Component Signal Transduction Systems in Oral Streptococci: Structure and Function

by
Yue Zu
†,
Wei Li
†,
Qi Wang
,
Jiahao Chen
and
Qiang Guo
*
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
*
Author to whom correspondence should be addressed.
†
Yue Zu and Wei Li contributed equally to this review.
Curr. Issues Mol. Biol. 2019, 32(1), 201-258; https://doi.org/10.21775/cimb.032.201
Submission received: 7 March 2019 / Revised: 14 April 2019 / Accepted: 9 May 2019 / Published: 5 June 2019
Versions Notes

Abstract

Oral streptococci depend on two-component signal transduction systems (TCSs), the most widespread regulatory systems in bacteria, to detect and respond to diverse stresses in oral environment. Among the larger panel of TCSs equipped by oral streptococci, ComDE TCS is thought to be one of the most classical TCSs. So far, it has been proved that ComDE TCS could play critical roles in environmental stress responses to acid, antibiotic, oxidative pressures and so on, and modulating multiple virulence traits like biofilm formation, bacteriocin production, competence, autolysis. Here, the well characterized Streptococcus mutans and Streptococcus pneumoniae are chosen as the representative species to introduce the composition, signaling pathways and regulated phenotypes of ComDE TCS in oral streptococci. The potential ComDE TCS-targeted antimicrobial applications are also discussed at last.
Keywords: ComDE; two-component; signal; transduction; systems; streptococci; structure; function ComDE; two-component; signal; transduction; systems; streptococci; structure; function

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MDPI and ACS Style

Zu, Y.; Li, W.; Wang, Q.; Chen, J.; Guo, Q. ComDE Two-Component Signal Transduction Systems in Oral Streptococci: Structure and Function. Curr. Issues Mol. Biol. 2019, 32, 201-258. https://doi.org/10.21775/cimb.032.201

AMA Style

Zu Y, Li W, Wang Q, Chen J, Guo Q. ComDE Two-Component Signal Transduction Systems in Oral Streptococci: Structure and Function. Current Issues in Molecular Biology. 2019; 32(1):201-258. https://doi.org/10.21775/cimb.032.201

Chicago/Turabian Style

Zu, Yue, Wei Li, Qi Wang, Jiahao Chen, and Qiang Guo. 2019. "ComDE Two-Component Signal Transduction Systems in Oral Streptococci: Structure and Function" Current Issues in Molecular Biology 32, no. 1: 201-258. https://doi.org/10.21775/cimb.032.201

APA Style

Zu, Y., Li, W., Wang, Q., Chen, J., & Guo, Q. (2019). ComDE Two-Component Signal Transduction Systems in Oral Streptococci: Structure and Function. Current Issues in Molecular Biology, 32(1), 201-258. https://doi.org/10.21775/cimb.032.201

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