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Volume 33
Issue 1
10.21775/cimb.033.225
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Bioconversion of Methanol into Value-Added Chemicals in Native and Synthetic Methylotrophs

by
Min Zhang
1,
Xiao-jie Yuan
1,
Cong Zhang
1,
Li-ping Zhu
1,
Xu-hua Mo
1,
Wen-jing Chen
1 and
Song Yang
1,2,*
1
School of Life Science, Qingdao Agricultural University, Shandong Province Key Laboratory of Applied Mycology, and Qingdao International Center on Microbes Utilizing Biogas, Qingdao, China
2
Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2019, 33(1), 225-236; https://doi.org/10.21775/cimb.033.225
Submission received: 4 March 2019 / Revised: 8 April 2019 / Accepted: 6 May 2019 / Published: 5 June 2019

Abstract

Methanol, commercially generated from methane, is a renewable chemical feedstock that is highly soluble, relatively inexpensive, and easy to handle. The concept of native methylotrophic bacteria serving as whole cell catalysts for production of chemicals and materials using methanol as a feedstock is highly attractive. In recent years, the available omics data for methylotrophic bacteria, especially for Methylobacterium extorquens, the most well-characterized model methylotroph, have provided a solid platform for rational engineering of methylotrophic bacteria for industrial production. In addition, there is a strong interest in converting the more traditional heterotrophic production platforms toward the use of single carbon substrates, including methanol, through metabolic engineering. In this chapter, we review the recent progress toward achieving the desired growth and production yields from methanol, by genetically engineered native methylotrophic strains and by the engineered synthetic methylotrophs.

Share and Cite

MDPI and ACS Style

Zhang, M.; Yuan, X.-j.; Zhang, C.; Zhu, L.-p.; Mo, X.-h.; Chen, W.-j.; Yang, S. Bioconversion of Methanol into Value-Added Chemicals in Native and Synthetic Methylotrophs. Curr. Issues Mol. Biol. 2019, 33, 225-236. https://doi.org/10.21775/cimb.033.225

AMA Style

Zhang M, Yuan X-j, Zhang C, Zhu L-p, Mo X-h, Chen W-j, Yang S. Bioconversion of Methanol into Value-Added Chemicals in Native and Synthetic Methylotrophs. Current Issues in Molecular Biology. 2019; 33(1):225-236. https://doi.org/10.21775/cimb.033.225

Chicago/Turabian Style

Zhang, Min, Xiao-jie Yuan, Cong Zhang, Li-ping Zhu, Xu-hua Mo, Wen-jing Chen, and Song Yang. 2019. "Bioconversion of Methanol into Value-Added Chemicals in Native and Synthetic Methylotrophs" Current Issues in Molecular Biology 33, no. 1: 225-236. https://doi.org/10.21775/cimb.033.225

APA Style

Zhang, M., Yuan, X. -j., Zhang, C., Zhu, L. -p., Mo, X. -h., Chen, W. -j., & Yang, S. (2019). Bioconversion of Methanol into Value-Added Chemicals in Native and Synthetic Methylotrophs. Current Issues in Molecular Biology, 33(1), 225-236. https://doi.org/10.21775/cimb.033.225

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