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Volume 42
Issue 1
10.21775/cimb.042.191
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Human and Veterinary Vaccines for Lyme Disease

by
Nathaniel S. O'Bier
,
Amanda L. Hatke
,
Andrew C. Camire
and
Richard T. Marconi
*
Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2021, 42(1), 191-222; https://doi.org/10.21775/cimb.042.191
Submission received: 7 September 2020 / Revised: 4 October 2020 / Accepted: 5 November 2020 / Published: 8 December 2020
Versions Notes

Abstract

Lyme disease (LD) is an emerging zoonotic infection that is increasing in incidence in North America, Europe, and Asia. With the development of safe and efficacious vaccines, LD can potentially be prevented. Vaccination offers a cost-effective and safe approach for decreasing the risk of infection. While LD vaccines have been widely used in veterinary medicine, they are not available as a preventive tool for humans. Central to the development of effective vaccines is an understanding of the enzootic cycle of LD, differential gene expression of Borrelia burgdorferi in response to environmental variables, and the genetic and antigenic diversity of the unique bacteria that cause this debilitating disease. Here we review these areas as they pertain to past and present efforts to develop human, veterinary, and reservoir targeting LD vaccines. In addition, we offer a brief overview of additional preventative measures that should employed in conjunction with vaccination.

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MDPI and ACS Style

O'Bier, N.S.; Hatke, A.L.; Camire, A.C.; Marconi, R.T. Human and Veterinary Vaccines for Lyme Disease. Curr. Issues Mol. Biol. 2021, 42, 191-222. https://doi.org/10.21775/cimb.042.191

AMA Style

O'Bier NS, Hatke AL, Camire AC, Marconi RT. Human and Veterinary Vaccines for Lyme Disease. Current Issues in Molecular Biology. 2021; 42(1):191-222. https://doi.org/10.21775/cimb.042.191

Chicago/Turabian Style

O'Bier, Nathaniel S., Amanda L. Hatke, Andrew C. Camire, and Richard T. Marconi. 2021. "Human and Veterinary Vaccines for Lyme Disease" Current Issues in Molecular Biology 42, no. 1: 191-222. https://doi.org/10.21775/cimb.042.191

APA Style

O'Bier, N. S., Hatke, A. L., Camire, A. C., & Marconi, R. T. (2021). Human and Veterinary Vaccines for Lyme Disease. Current Issues in Molecular Biology, 42(1), 191-222. https://doi.org/10.21775/cimb.042.191

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