The “Viral” Form of Polyarteritis Nodosa (PAN)—A Distinct Entity: A Case Based Review
, Mihaela Poroch 2,3,*, Adriana Cosmescu 2,3, Agnes Iacinta Bacusca 2,3, Ana Maria Slanina 2,3, Alexandr Ceasovschih 2,4, Alexandra Stoica 2,4, Antoneta Petroaie 2,3, Monica Ungureanu 2,3, Andrei Emilian Popa 2, Raluca Ioana Avram 2, Cristina Bologa 2,4, Vladimir Poroch 2 and Elena Adorata Coman 2,3,4
Round 1
Reviewer 1 Report
In this case report the authors describe a case of 44 years old presenting with acute ischemia phenomenon right hand with compartment syndrome. Although the diagnosis was challenging and the disease is very rare , this case has not a special unique presentation. The association with PAN e n Virus B also is well known
DIfferential diagnosi is missing.. for exaple crioglobulinemic vasculitis
For therapy , plasma exchange could be discussed
Author Response
I thank you for your review. I have made changes to the article according to your comments
Point 1: DIfferential diagnosi is missing.. for exaple crioglobulinemic vasculitis
Response 1: We have included the differential diagnosis in the article, including cryoglobulinemic vasculitis
Point 2: For therapy , plasma exchange could be discussed
Response 2: In the updated version, we completed the treatment for HBV-related PANA, and we also discussed plasmapheresis.
Kind regards,
Elena Popa,
MD, PhD.
Author Response File: 
Author Response.docx
Reviewer 2 Report
The article is clear and well structured.
The patient's case is well presented.
However, in my opinion, the "review" section has not been deepened afterwards , a table showing the main elements for diagnosis (divided by body organ) and treatment of the condition would be very helpful
there is a great deal of attention to the description of the individual case but little depth to the relevant literature, an important prerogative in the publication of a review
Minor editing of English language required
Author Response
I thank you for your review. I have made changes to the article according to your comments
Point 1: However, in my opinion, the "review" section has not been deepened afterwards , a table showing the main elements for diagnosis (divided by body organ) and treatment of the condition would be very helpful
Response 1: We have completed the "review" section and we have included the requested table.
Point 2: there is a great deal of attention to the description of the individual case but little depth to the relevant literature, an important prerogative in the publication of a review
Response 2: In the updated work, we made a synthesis of the current articles in the field of HBV-PAN. We hope you consider the article good for publication.
Kind regards,
Elena Popa
MD, PhD
Round 2
Reviewer 1 Report
the authors improve substantially the manuscript, I do not have major concerns
