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Current Oncology
Volume 18
Issue s2
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..

Curr. Oncol., Volume 18, Issue s2 (October 2011) – 3 articles

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Article
Progression-Free Survival as a Clinical Trial Endpoint in Advanced Renal Cell Carcinoma
by S.J. Hotte, G.A. Bjarnason, D.Y.C. Heng, M.A.S. Jewett, A. Kapoor, C. Kollmannsberger, J. Maroun, L.A. Mayhew, S. North, M.N. Reaume, J.D. Ruether, D. Soulieres, P.M. Venner, E.W. Winquist, L. Wood, J.H.E. Yong and F. Saad
Curr. Oncol. 2011, 18(s2), 11-19; https://doi.org/10.3747/co.v18is2.958 - 1 Oct 2011
Cited by 24 | Viewed by 1234
Abstract
Traditionally, overall survival (os) has been considered the “gold standard” for evaluating new systemic oncologic therapies, because death is easy to define, is easily compared across disease sites, and is not subject to investigator bias. However, as the available options for [...] Read more.
Traditionally, overall survival (os) has been considered the “gold standard” for evaluating new systemic oncologic therapies, because death is easy to define, is easily compared across disease sites, and is not subject to investigator bias. However, as the available options for continuing therapy increase, the use of os as a clinical trial endpoint has become problematic because of the increasing crossover and contamination of trials. As a result, the approval of promising new therapies may be delayed. Many clinicians believe that progression-free survival (pfs) is a more viable option for evaluating new therapies in metastatic and advanced renal cell carcinoma. As with all endpoints, pfs has inherent biases, and those biases must be addressed to ensure that trial results are not compromised and that they will be accepted by regulatory authorities. In this paper, we examine the issues surrounding the use of pfs as a clinical trial endpoint, and we suggest solutions to ensure that data integrity is maintained. Full article
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Article
Progression-Free Survival as a Primary Endpoint in Clinical Trials of Metastatic Colorectal Cancer
by S. Gill, S. Berry, J. Biagi, C. Butts, M. Buyse, E. Chen, D. Jonker, C. Mărginean, B. Samson, J. Stewart, M. Thirlwell, R. Wong and J.A. Maroun
Curr. Oncol. 2011, 18(s2), 5-10; https://doi.org/10.3747/co.v18is2.941 - 1 Oct 2011
Cited by 19 | Viewed by 906
Abstract
In recent years, significant advances have been made in the management of metastatic colorectal cancer. Traditionally, an improvement in overall survival has been considered the “gold standard”—the most convincing measure of efficacy. However, overall survival requires larger patient numbers and longer follow-up and [...] Read more.
In recent years, significant advances have been made in the management of metastatic colorectal cancer. Traditionally, an improvement in overall survival has been considered the “gold standard”—the most convincing measure of efficacy. However, overall survival requires larger patient numbers and longer follow-up and may often be confounded by other factors, including subsequent therapies and crossover. Given the number of active therapies for potential investigation, demand for rapid evaluation and early availability of new therapies is growing. Progression-free survival is regarded as an important measure of treatment benefit and, compared with overall survival, can be evaluated earlier, with fewer patients and no confounding by subsequent lines of therapy. The present paper reviews the advantages, limitations, and relevance of progression-free survival as a primary endpoint in randomized trials of metastatic colorectal cancer. Full article
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Editorial
The Significance of Progressionfree Survival as an Endpoint in Evaluating the Therapeutic Value of Antineoplastic Agents
by J.A. Maroun
Curr. Oncol. 2011, 18(s2), 3-4; https://doi.org/10.3390/curroncol18120004 - 1 Oct 2011
Cited by 2 | Viewed by 434
Abstract
In the last decade, thanks to the development of new and effective cytotoxic and biologic agents, significant progress has been achieved in the treatment of various forms of cancer. [...] Full article
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