Survival Benefits of Adjuvant Chemotherapy for Positive Soft Tissue Surgical Margins Following Radical Cystectomy in Bladder Cancer with Extravesical Extension
, Facundo Davaro, Philippe E. Spiess, Logan Zemp, Michael Poch, Rohit Jain, Aram Vosoughi, G. Daniel Grass, Alice Yu, Wade J. Sexton, Scott M. Gilbert and Roger Li
Round 1
Reviewer 1 Report
I compliment the Authors for the interesting casistic presented. The paper is well written and the statistic is clear. The principal limitation is the retrospective casistic, which may have several bias.
However, I fell that the paper is scientifically relevant and should be published in this actual form.
Author Response
We appreciate the reviewer's favorable comments regarding the manuscript.
Reviewer 2 Report
This manuscript examines the association between a positive soft tissue surgical margin after radical cystectomy in bladder cancer with extravesical extension and a favorable response to adjuvant chemotherapy following radical cystectomy in bladder cancer with extravesical extension.
Although the topic is not new, the academic community always finds this communication exciting and well-received.
It is a well-designed manuscript that includes an impressive number of patients and a good statistical analysis to show the effectiveness of the study.
It is evident from the introduction that there is a great deal of information and that it is concise. The method is clearly explained, and the results are supported by tables and figures that are clearly visible to the reader. The discussion contains a significant amount of documentation, as well as a recent biography that provides a clear focus. As mentioned in the introduction, the conclusions align with the objectives.
This article would be an excellent addition to any publication since it draws the readers' attention to a topic they may find intriguing.
Upon minor corrections in the overall English, the article should be suitable for publication.
Author Response
We appreciate the reviewer's favorable opinion of the manuscript, and will perform the recommended minor grammatical corrections on final review.
Reviewer 3 Report
Murthy et al. present an interesting topic that adjuvant chemotherapy on positive soft tissue surgical margins following radical cystectomy can increase the survival of bladder cancer patients with extravesical extension. They did a comprehensive analysis on a bladder cancer patient cohort who received radical cystectomy and neoadjuvant chemotherapy. It turns out bladder cancer patients with positive soft-tissue surgical margin can benefits from adjuvant chemotherapy following radical cystectomy. In general, this study is properly designed, and the results are clear and sound, and the references are relevant and updated.
Author Response
We appreciate the reviewer's reception of our manuscript.
