Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Study Protocol
2.3. Laboratory Analysis
2.4. Statistical Analysis
2.5. Statistical Modeling
3. Results
Association between Body Mass Index and Cortisol Parameters
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Parameter | Index |
---|---|
(THF + allo-THF + THE + α-cortol + β-cortol + α-cortolone + β-cortolone)/creatinine | Sum of cortisol metabolites (cortisol metabolite excretion rate) |
allo-THF/F | 5α-reductase activity |
THF/F | 5β-reductase activity (a) |
THE/E | 5β-reductase activity (b) |
F/E | 11β-HSD type 2 activity |
(THF + allo-THF)/THE | Balance of 11β-HSD activities |
6β-OH cortisol/F | Cytochrome P450 3A4 activity |
9 years (n = 207) | 12 years (n = 175) | 17 years (n = 174) | ||
---|---|---|---|---|
Height | cm | 138.7 ± 5.2 | 152.3 ± 7.1 | 173.6 ± 8.2 |
SDS | 0.04 ± 0.82 | −0.56± 0.98 | −0.16 ± 0.88 | |
Weight | kg | 31.4 ± 4.5 | 43.0 ± 9.0 | 64.0 ± 9.6 |
SDS | 0.31 ± 0.93 | 0.23± 0.99 | 0.26 ± 1.06 | |
Body mass index | kg/m2 | 16.3 ± 1.7 | 18.7 ± 2.5 | 21.3 ± 3.0 |
SDS | 0.14 ± 0.93 | 0.45 ± 1.00 | 0.27 ± 1.08 |
Index | bxy1 | bxy2 | P-Value | byx1 | byx2 | P-Value |
---|---|---|---|---|---|---|
Sum of cortisol metabolites (cortisol metabolite excretion rate) | 0.12 (0.00–0.23) | 0.15 (0.01–0.29) | 0.03 | 0.08 (−0.00–0.15) | 0.02 (−0.08–0.13) | 0.33 |
5α-reductase activity | 0.02 (−0.12–0.16) | −0.13 (−0.26–0.00) | 0.30 | 0.03 (−0.04–0.11) | 0.05 (−0.07–0.17) | 0.57 |
5β-reductase activity (a) | 0.01 (−0.09–0.11) | 0.09 (−0.03–0.21) | 0.42 | 0.00 (−0.05–0.06) | 0.09 (0.01–0.17) | 0.15 |
5β-reductase activity (b) | 0.08 (−0.06–0.21) | −0.11 (−0.26–0.04) | 0.33 | 0.07 (−0.01–0.14) | 0.04 (−0.04–0.13) | 0.21 |
11β-HSD type 2 activity | 0.08 (−0.05–0.20) | −0.04 (−0.20–0.13) | 0.61 | −0.01 (−0.07–0.05) | −0.04 (−0.12–0.04) | 0.65 |
Balance of 11β-HSD activities | −0.10 (−0.19–0.01) | 0.12 (−0.01–0.25) | 0.07 | 0.03 (−0.06–0.13) | 0.06 (−0.03–0.15) | 0.55 |
Cytochrome P450 3A4 activity | −0.08 (−0.24–0.07) | 0.01 (−0.16–0.18) | 0.65 | 0.02 (−0.05–0.09) | 0.16 (0.07–0.24) | 0.01 |
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Van Keulen, B.J.; Dolan, C.V.; Andrew, R.; Walker, B.R.; Hulshoff Pol, H.E.; Boomsma, D.I.; Rotteveel, J.; Finken, M.J.J. Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood. Nutrients 2020, 12, 1525. https://doi.org/10.3390/nu12051525
Van Keulen BJ, Dolan CV, Andrew R, Walker BR, Hulshoff Pol HE, Boomsma DI, Rotteveel J, Finken MJJ. Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood. Nutrients. 2020; 12(5):1525. https://doi.org/10.3390/nu12051525
Chicago/Turabian StyleVan Keulen, Britt J., Conor V. Dolan, Ruth Andrew, Brian R. Walker, Hilleke E. Hulshoff Pol, Dorret I. Boomsma, Joost Rotteveel, and Martijn J.J. Finken. 2020. "Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood" Nutrients 12, no. 5: 1525. https://doi.org/10.3390/nu12051525
APA StyleVan Keulen, B. J., Dolan, C. V., Andrew, R., Walker, B. R., Hulshoff Pol, H. E., Boomsma, D. I., Rotteveel, J., & Finken, M. J. J. (2020). Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood. Nutrients, 12(5), 1525. https://doi.org/10.3390/nu12051525