Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of IR-780-Loaded Liposomes (ILs)
2.3. Characteristic of IR-780-Loaded Liposomes (ILs)
2.4. Photothermal and Photodynamic Effects
2.5. Intracellular Uptake and Cytotoxicity
2.6. Intracranial Xenograft Tumor Model
2.7. Convection-Enhanced Delivery (CED)
2.8. Bio-Distribution and In Vivo Fluorescence Imaging
2.9. In Vivo Photothermal Effects
2.10. In Vivo Anti-Tumor Efficacy
2.11. Magnetic Resonance Imaging (MRI) and Positron Emission Tomography/Computed Tomography (PET/CT) Study
2.12. Histological Analysis
2.13. Statistical Analysis
3. Results and Discussion
3.1. Characterization of ILs
3.2. In Vitro Photothermal and Photodynamic Study
3.3. In Vitro Cell Culture Experiments
3.4. Bio-Distribution and In Vivo Photothermal Effects
3.5. MRI and PET/CT Studies
3.6. Histological Analysis
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Lu, Y.-J.; S., A.T.; Chuang, C.-C.; Chen, J.-P. Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery. Cancers 2021, 13, 3690. https://doi.org/10.3390/cancers13153690
Lu Y-J, S. AT, Chuang C-C, Chen J-P. Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery. Cancers. 2021; 13(15):3690. https://doi.org/10.3390/cancers13153690
Chicago/Turabian StyleLu, Yu-Jen, Anilkumar T. S., Chi-Cheng Chuang, and Jyh-Ping Chen. 2021. "Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery" Cancers 13, no. 15: 3690. https://doi.org/10.3390/cancers13153690
APA StyleLu, Y. -J., S., A. T., Chuang, C. -C., & Chen, J. -P. (2021). Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery. Cancers, 13(15), 3690. https://doi.org/10.3390/cancers13153690