Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Definitions
4. The Selection Criteria for (Bi)Segmentectomy
5. Results
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Aronson, D.C.; Czauderna, P.; Maibach, R.; Perilongo, G.; Morland, B. The treatment of hepatoblastoma: Its evolution and the current status as per the SIOPEL trials. J. Indian Assoc. Pediatr. Surg. 2014, 19, 201–207. [Google Scholar] [CrossRef] [PubMed]
- Aronson, D.C.; Meyers, R.L. Malignant tumors of the liver in children. Semin. Pediatr. Surg. 2016, 25, 265–275. [Google Scholar] [CrossRef] [PubMed]
- Lim, I.I.P.; Bondoc, A.J.; Geller, J.I.; Tiao, G.M. Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation. Children 2019, 6, 1. [Google Scholar] [CrossRef] [PubMed]
- Li, K.; Jiang, F.; Aizpuru, M.; Larson, E.L.; Xie, X.; Zhou, R.; Xiang, B. Succesful management and technical aspects of major liver resection in children. Medicine 2021, 100, e24420. [Google Scholar] [CrossRef] [PubMed]
- Benedict, M.; Zhang, X. Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review. Arch. Pathol. Lab. Med. 2019, 143, 264–268. [Google Scholar] [CrossRef] [PubMed]
- Yoshida, H.; Katayose, Y.; Rikiyama, T.; Motoi, F.; Yoshida, H.; Katayose, Y.; Rikiyama, T.; Motoi, F.; Onogawa, T.; Egawa, S.; et al. Segmentectomy of the liver. J. Hepatobiliary Pancreat Sci. 2012, 19, 67–71. [Google Scholar] [CrossRef]
- Patel, U.; Abernathy, J.; Savani, B.N.; Oluwole, O.; Sengsayadeth, S.; Dholaria, B. CAR T cell therapy in solid tumors: A review of current clinical trials. eJHaem 2022, 3 (Suppl. S1), 24–31. [Google Scholar] [CrossRef]
- Qureshi, S.S.; Kembhavi, S.A.; Kazi, M.; Smriti, V.; Baheti, A.; Vora, T.; Chinnaswamy, G.; Prasad, M.; Amin, N.; Ramadwar, M.; et al. Feasibility of Nonanatomical Liver Resection in Diligently Selected Patients with Hepatoblastoma and Comparison of Outcomes with Anatomic Resection. Eur. J. Pediatr. Surg. 2021, 31, 236–244. [Google Scholar] [CrossRef]
- Liu, J.; Zhang, Y.; Zhu, H.; Qiu, L.; Guo, C. Prediction of perioperative outcome after hepatic resection for pediatric patients. BMC Gastroenterol. 2019, 19, 201. [Google Scholar] [CrossRef]
- Fuchs, J.; Rydzynski, J.; Von Schweinitz, D.; Bode, U. Pretreatment Prognostic Factors and Treatment Results in Children with Hepatoblastoma. A Report from the German Cooperative Pediatric Liver Tumor Study HB 94. Cancer 2002, 95, 172–182. [Google Scholar] [CrossRef]
- Sutherland, F.; Harris, J. Claude Couinaud. A Passion for the Liver. Arch. Surg. 2002, 137, 1305–1310. [Google Scholar] [CrossRef] [PubMed]
- Meyers, R.L.; Czauderna, P.; Otte, J.-B. Surgical Treatment of Hepatoblastoma. Pediatr. Blood Cancer 2012, 59, 800–808. [Google Scholar] [CrossRef] [PubMed]
- Meyers, R.L.; Tiao, G.; de Goyet, J.d.V.; Superina, R.; Aronson, D.C. Hepatoblastoma state of the art: Pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation. Curr. Opin. Pediatr. 2014, 26, 29–36. [Google Scholar] [CrossRef] [PubMed]
- Czauderna, P.; Otte, J.-B.; Roebuck, D.J.; von Schweinitz, D.; Plaschkes, J. Surgical treatment of hepatoblastoma in children. Pediatr. Radiol. 2006, 36, 187–191. [Google Scholar] [CrossRef] [PubMed]
- Makuuchi, M.; Hasegawa, H.; Yamazaki, S. Ultrasonically quided subsegmentectomy. Surg. Gynecol. Obstet 1985, 161, 346–350. [Google Scholar] [PubMed]
- Cazauran, J.B.; Pâris, L.; Rousset, P.; Mercier, F.; Kepenekian, V.; Viste, A.; Passot, G. Anatomy of the Right Anterior Sector of the Liver and Its Clinical Implications in Surgery. J. Gastrointest. Surg. 2018, 22, 1819–1831. [Google Scholar] [CrossRef]
- Yamashita, S.; Venkatesan, A.M.; Mizuno, T.; Aloia, T.A.; Chun, Y.S.; Lee, J.E.; Vauthey, J.-N.; Conrad, C. Remnant Liver Ischemia as a Prognostic Factor for Cancer-Specific Survival After Resection of Colorectal Liver Metastases. JAMA Surg. 2017, 152, e172986. [Google Scholar] [CrossRef]
- Mohkam, K.; Farges, O.; Vibert, E.; Soubrane, O.; Adam, R.; Pruvot, F.-R.; Regimbeau, J.M.; Adham, M.; Boleslawski, E.; Mabrut, J.-Y.; et al. Risk score to predict biliary leakage after elective liver resection: Posthepatectomy biliary leakage. Br. J. Surg. 2017, 105, 128–139. [Google Scholar] [CrossRef]
- Wiederkehr, J.C.; Avilla, S.G.; Mattos, E.; Coelho, I.M.; Ledesma, J.A.; Conceição, A.F.; Wiederkehr, H.A.; Wiederkehr, B.A. Associating liver partition with portal vein ligation and staged hepatectomy (ALPPS) for the treatment of liver tumors in children. J. Pediatr. Surg. 2015, 50, 1227–1231. [Google Scholar] [CrossRef]
- Yang, T.; Whitlock, R.S.; Vasudevan, S.A. Surgical management of hepatoblastoma and recent advances. Cancers 2019, 11, 1944. [Google Scholar] [CrossRef]
- Aronson, D.C.; Weeda, V.B.; Maibach, R.; Czauderna, P. Microscopically positive resection margin after hepatoblastoma resection: What is the impact on prognosis? A Childhood Liver Tumours Strategy Group (SIOPEL) report. Eur. J. Cancer 2019, 106, 126–132. [Google Scholar] [CrossRef] [PubMed]
- De Campos Vieira Abib, S.; Chui, C.H.; Cox, S.; Abdelhafeez, A.H.; Fernandez-Pineda, I.; Elgendy, A.; Karpelowsky, J.; Lobos, P.; Wijnen, M.; Fuchs, J.; et al. International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines. Ecancermedicalscience 2022, 16, 1356. [Google Scholar] [CrossRef] [PubMed]
Tumour | Diagnoses | n = 87 | Type of Resection | n |
---|---|---|---|---|
Malignant | Hepatoblastoma | 61 | Right hemihepatectomy | 18 |
Extended right hemihepatectomy | 9 | |||
Left hemihepatectomy | 14 | |||
Extended left hemihepatectomy | 5 | |||
ALPPS | 2 | |||
Segmentectomy | 13 | |||
HCC | 4 | Right hemihepatectomy | 3 | |
Left hemihepatectomy | 1 | |||
Sarcoma | 3 | Right hemihepatectomy | 1 | |
Extended right hemihepatectomy | 1 | |||
Segmentectomy | 1 | |||
Metastases | 2 | Nonanatomical resection | 1 | |
Segmentectomy | 1 | |||
Rhabdoid tumour | 1 | Nonanatomical resection | 1 | |
Benign | FNH | 6 | Extended right hemihepatectomy | 1 |
Nonanatomical resection | 1 | |||
Segmentectomy | 4 | |||
Hamartoma | 6 | Right hemihepatectomy | 1 | |
Extended right hemihepatectomy | 3 | |||
Segmentectomy | 2 | |||
Vascular tumour | 2 | Nonanatomical resection | 1 | |
Segmentectomy | 1 | |||
Adenoma | 1 | Left hemihepatectomy | 1 | |
Other | CNSET | 1 | Segmentectomy | 1 |
Demographics | ||
---|---|---|
Age in months (median) | 4–158 (20) | |
Gender | female—7, male—16 | |
Diagnosis | Hepatoblastoma | 13 |
FNH | 4 | |
Hamartoma | 2 | |
UESL | 1 | |
Vascular tumour | 1 | |
CNSET | 1 | |
Nephroblastoma metastasis | 1 | |
The largest tumour diameter in millimetres (median) | 15–170 (52) | |
Metastases | 1—lung | |
Intra- and postoperative variables | ||
Segment resected | Segment | n |
1 | 1 | |
2 + 3 * | 7 * | |
3 | 2 | |
5 | 2 | |
5 + 6 | 4 | |
6 | 1 | |
6 + 7 | 2 | |
7 ** | 1 ** | |
7 + 8 | 3 | |
Duration of surgery in minutes (median) | 95–643 (225) | |
Intraoperative complications | 1—intestinal perforation, 1—peripheral bile duct injury | |
Hospital stay in days (median) | 4–14 (9) |
Segment resected | Segment | n |
1 | 1 | |
2 + 3 | 2 | |
3 | 1 | |
5 | 2 | |
5 + 6 | 3 | |
6 + 7 | 2 | |
7 + 8 | 2 | |
The largest tumour diameter in millimetres (median) | 16–78 (50) | |
Duration of surgery in minutes (median) | 95–360 (240) | |
Margin in millimetres | 1–15 (3) | |
Margin positive | 1 | |
Recurrence | 2 | |
Follow-up | 38 months (range 12–144 months) | |
Complete remission | 13 (100%) |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Murawski, M.; Garnier, H.; Stefanowicz, J.; Sinacka, K.; Izycka-Swieszewska, E.; Sawicka-Zukowska, M.; Wawrykow, P.; Wrobel, G.; Mizia-Malarz, A.; Marciniak-Stepak, P.; et al. Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience. Cancers 2024, 16, 38. https://doi.org/10.3390/cancers16010038
Murawski M, Garnier H, Stefanowicz J, Sinacka K, Izycka-Swieszewska E, Sawicka-Zukowska M, Wawrykow P, Wrobel G, Mizia-Malarz A, Marciniak-Stepak P, et al. Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience. Cancers. 2024; 16(1):38. https://doi.org/10.3390/cancers16010038
Chicago/Turabian StyleMurawski, Maciej, Hanna Garnier, Joanna Stefanowicz, Katarzyna Sinacka, Ewa Izycka-Swieszewska, Malgorzata Sawicka-Zukowska, Pawel Wawrykow, Grazyna Wrobel, Agnieszka Mizia-Malarz, Patrycja Marciniak-Stepak, and et al. 2024. "Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience" Cancers 16, no. 1: 38. https://doi.org/10.3390/cancers16010038
APA StyleMurawski, M., Garnier, H., Stefanowicz, J., Sinacka, K., Izycka-Swieszewska, E., Sawicka-Zukowska, M., Wawrykow, P., Wrobel, G., Mizia-Malarz, A., Marciniak-Stepak, P., & Czauderna, P. (2024). Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience. Cancers, 16(1), 38. https://doi.org/10.3390/cancers16010038