Impact of COVID-19 Pandemic on Delay of Melanoma Diagnosis: A Systematic Review and Meta-Analysis
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Data Collection and Meta-Analysis
3. Results
3.1. Study Selection and Data Extraction
3.2. Prognostic Factors
3.2.1. Thickness
3.2.2. Ulceration
3.2.3. AJCC Stage
3.2.4. Histopathological Subtype
3.2.5. Mitoses
4. Discussion
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Paper ID | First Author (Reference) | Publication Year | Country | Dates of Study Periods | Participants | Age, Years (SD) | Sex | Reported Outcomes * | |
---|---|---|---|---|---|---|---|---|---|
M | F | ||||||||
1 | Barruscotti [8] | 2020 | Italy | February 2019–May 2019 | 42 | 63 (16) | 23 | 22 | Breslow thickness |
February 2020–May 2020 | 6 | 63 (16) | 5 | 1 | |||||
2 | Ricci [9] | 2020 | Italy | January 2020–March 2020 | 158 | NR | NR | NR | Histological subtype and ulceration |
March 2020–May 2020 | 34 | ||||||||
May 2020–June 020 | 45 | ||||||||
January 2021–June 2021 | 294 | ||||||||
3 | Cariti [10] | 2021 | Italy | May 2017–June 2017 | 51 | 61.0 | 31 | 20 | Breslow thickness Histological subtype |
May 2018–June 2018 | 41 | 62.0 | 20 | 21 | |||||
May 2019–June 2019 | 48 | 61.0 | 31 | 17 | |||||
May 2020–June 2020 | 32 | 55.0 | 16 | 16 | |||||
4 | Fernández-Canedo [11] | 2021 | Spain | April 2019–August 2019 | 48 | NR | NR | NR | Ulceration Mitosis |
April 2020–August 2020 | 18 | ||||||||
5 | Gedeah [12] | 2021 | Belgium | March 2018–December 2018 | 169 | NR | NR | NR | Breslow thickness |
March 2019–December 2019 | 161 | ||||||||
March 2020–December 2020 | 140 | ||||||||
6 | Gisondi [13] | 2021 | Italy | March 2019–October 2019 | 634 | 61.0 (3.6) | 351 | 283 | Breslow thickness |
March 2020–October 2020 | 556 | 62.2 (3.6) | 314 | 242 | |||||
7 | Gualdi [14] | 2021 | Italy | March 2017–July 2019 | 220 | NR | 262 | 271 | Ulceration Mitosis |
March 2020–July 2020 | 168 | ||||||||
8 | Hoellwerth [15] | 2021 | Austria | March 2018–June 2018 | 428 | 61.0 | 228 | 200 | Ulceration |
March 2019–June 2019 | 505 | 60.0 | 260 | 245 | |||||
March 2020–June 2020 | 432 | 63.0 | 233 | 199 | |||||
9 | Javor [16] | 2021 | Italy | January 2019–December 2019 | 138 | NR | NR | NR | Breslow thickness |
January 2020–December 2020 | 87 | ||||||||
10 | Koch [17] | 2021 | Greece | January 2019–March 2020 | 191 | 52.8 | 80 54 | 110 51 | Breslow thickness |
April 2020–March 2021 | 105 | 53.3 | |||||||
11 | Lo Bello [18] | 2021 | Italy | March 2019–December 2019 | 104 | NR | NR | NR | Ulceration |
March 2020–December 2020 | 91 | ||||||||
12 | Lallas [19] | 2021 | Greece | 2016–2019 | 165 | 58.7 (15.1) | 140 | 130 | Breslow thickness Tumor staging |
2020 | 105 | 51.1 (11.4) | |||||||
13 | McFeely [20] | 2021 | Ireland | 2019 | 78 | 68.5 75.5 | 73 | 89 | Ulceration |
2020 | 84 | ||||||||
14 | Shannon [21] | 2021 | USA | June 2019–August 2019 | 172 | 68.0 | 96 | 76 | Ulceration Mitosis |
June 2020–August 2020 | 153 | 68.0 | 88 | 65 | |||||
15 | Tejera-Vaquerizo [22] | 2021 | Spain | March 2019–June 2019 | 303 | 64.0 (16.4) 62.9 (16.7) | NR | NR | Breslow Thickness Ulceration Tumor staging |
March 2020–June 2020 | 164 | ||||||||
16 | Aabed [23] | 2022 | Romania | January 2018–December 2019 | 163 | 58.1 (16.3) 58.8 (15.9) | 157 | 144 | Breslow thickness Ulceration Tumor staging Histological subtype |
January 2020–December 2020 | 138 | ||||||||
17 | Balakirski [24] | 2022 | Germany | January 2019–December 2019 | 320 | 63.7 (17.7) | NR | NR | Breslow thickness Tumor staging |
January 2020–December 2020 | 319 | 63.0 (19.4) | |||||||
January 2021–December 2021 | 347 | 65.7 (16.4) | |||||||
18 | Bowe [25] | 2022 | Ireland | January 2019–December 2019 | 52 | NR | 73 | 90 | Breslow thickness |
January 2020–December 2020 | 61 | ||||||||
January 2021–December 2021 | 51 | ||||||||
19 | Davis [26] | 2022 | USA | August 2019–March 2020 | 375 | 65.7 | 236 | 139 | Breslow Tickness Tumor staging |
May 2020–December 2020 | 313 | 67.0 | 182 | 131 | |||||
May 2019–June 2019 | 72 | NR | NR | NR | |||||
January 2020–February 2020 | 101 | NR | NR | NR | |||||
May 2020–June 2020 | 20 | NR | NR | NR | |||||
20 | Gil-Pallares [27] | 2022 | Spain | March 2019–September 2019 | 29 | 59 (18) | 14 | 15 | Breslow thickness Tumor staging |
September 2019–March 2020 | 36 | 70 (17) | 11 | 25 | |||||
March 2020–September 2020 | 24 | 66 (17) | 11 | 13 | |||||
September 2020–March 2021 | 30 | 69 (16) | 11 | 19 | |||||
21 | Heath [28] | 2022 | UK | November 2018–March 2020 | 276 | NR | 135 | 141 | Tumor staging Ulceration |
March 2020–March 2021 | 242 | 118 | 124 | ||||||
22 | Hurley [29] | 2022 | Ireland | March 2019–December 2019 | 277 | 68.5 | 137 | 140 | Breslow thickness Ulceration |
March 2020–December 2020 | 312 | 63.1 | 146 | 166 | |||||
23 | Jeremić [30] | 2022 | Serbia | January 2017–March 2020 | 311 | 64.5 (15.8) | 174 | 137 | Breslow thickness Ulceration Histological subtype |
March 2020–March 2022 | 82 | 65.7 (15.3) | 46 | 36 | |||||
24 | Kleemann [31] | 2022 | Germany | March 2019–March 2020 | 35,037 | NR | 19,305 | 15,732 | Breslow thickness |
March 2020–March 2021 | 32,189 | 17,414 | 14,775 | ||||||
25 | Lamm [32] | 2022 | USA | May 2019–May 2020 | 51 | 61.3 (2.1) | 32 | 19 | Breslow thickness Ulceration Histological subtype Tumor staging |
June 2020–September 2021 | 61 | 63 (2) | 32 | 29 | |||||
26 | Martinez-Lopez [33] | 2022 | Spain | March 2019–March 2020 | 77 | 63.3 (1.9) | 43 | 34 | Breslow thickness Ulceration |
March 2020–March 2021 | 53 | 65.0 (2.3) | 23 | 30 | |||||
27 | Molinier [34] | 2022 | France | March 2019–October 2019 | 257 | NR | NR | NR | Breslow thickness Ulceration Tumor staging Histological subtype Mitosis |
March 2020–May 2020 | 55 | ||||||||
May 2020–October 2020 | 181 | ||||||||
28 | Pissa [35] | 2022 | Sweden | April 2019–March 2020 | 126 | NR | NR | NR | Breslow thickness |
April 2020–March 2021 | 118 | ||||||||
29 | Sarriugarte Aldecoa-Otalora [36] | 2022 | Spain | March 2018–October 2019 | 155 | NR | NR | NR | Breslow thickness |
March 2020–October 2020 | 55 | ||||||||
30 | Scharf [37] | 2022 | Europe | 2019–2020 | 2311 | NR | NR | NR | Breslow thickness |
2020–2021 | 1722 | ||||||||
31 | Shaikh [38] | 2022 | USA | March 2019–March 2020 | 246 | NR | 130 137 | 116 109 | Tumor staging Histological subtype |
March 2020–January 2021 | 246 | ||||||||
32 | Trepanowski [39] | 2022 | USA | January 2019–February 2020 | 2062 | 65.5 | 1236 1053 | 826 781 | Breslow thickness Ulceration Tumor staging Histological subtype |
January 2020–February 2021 | 1834 | 65.8 | |||||||
33 | Ungureanu [40] | 2022 | Romania | March 2019–February 2020 | 341 | 59.0 | 164 | 177 | Ulceration Histological subtype |
March 2020–February 2021 | 275 | 63.0 | 138 | 137 | |||||
34 | Villani [41] | 2022 | Italy | 2018 | 216 | 55.4 | 13 | 17 | Breslow thickness |
2019 | 294 | 59.2 | 21 | 23 | |||||
2020 | 233 | 55.9 | 27 | 33 | |||||
2021 | 288 | 57.3 | 22 | 25 | |||||
35 | Welzel [42] | 2022 | Germany | January 2019 | 327 | NR | NR | NR | Ulceration |
January 2020 | 319 | ||||||||
January 2021 | 295 | ||||||||
36 | Drumm [43] | 2023 | Ireland | January 2019–December 2019 | 117 | NR | 58 | 59 | Breslow thickness Ulceration Histological subtype |
January 2020–December 2020 | 117 | 59 | 58 | ||||||
January 2021–December 2021 | 110 | 57 | 53 | ||||||
37 | Klepfisch [44] | 2023 | France | January 2019–March 2020 | 490 | 64.1 (14.5) | 267 | 223 | Ulceration Histological subtype Mitosis |
March 2020–May 2020 | 60 | 62.2 (16.2) | 38 | 22 | |||||
May 2020–November 2020 | 496 | 63.1 (15.1) | 269 | 227 | |||||
38 | Demaerel [45] | 2023 | Belgium | 2017 | 1029 | NR | NR | NR | Histological subtype |
2018 | 1007 | ||||||||
2019 | 884 | ||||||||
2020 | 961 | ||||||||
2021 | 1218 | ||||||||
39 | Kim [46] | 2023 | USA | 2019 | 20,074 | 65 (12) | 11,844 | 8230 | Breslow thickness Ulceration Tumor staging Histological subtype |
2020 | 16,945 | 65 (12) | 9828 | 7117 | |||||
40 | Pagliarello [47] | 2023 | Italy | March 2019–March 2020 | 402 | 59.4 (17.3) | 213 | 189 | Ulceration |
March 2020–March 2021 | 246 | 60.8 (17.7) | 117 | 129 | |||||
41 | Ruggiero [48] | 2023 | Italy | March 2019–March 2020 | 298 | NR | NR | NR | Breslow thickness |
March 2021–March 2022 | 560 | ||||||||
42 | Troesch [49] | 2023 | Europe | September 2018–March 2020 | 4340 | 62.3 (16.2) | 2300 | 2040 | Ulceration Histological subtype Mitosis |
March 2020–March 2020 | 3525 | 63.2 (15.6) | 1868 | 1657 | |||||
43 | Villani [50] | 2023 | Italy | January 2018–December 2018 | 216 | 55.4 | 94 | 122 | Breslow thickness |
January 2019–December 2019 | 294 | 59.2 | 140 | 154 | |||||
January 2020–December 2020 | 233 | 55.9 | 105 | 128 | |||||
January 2021–December 2021 | 288 | 57.3 | 135 | 153 | |||||
44 | Voigtländer [51] | 2023 | Germany | March 2019–February 2020 | 1392 | NR | NR | NR | Breslow thickness |
March 2020–February 2021 | 1158 | ||||||||
45 | Xiong [52] | 2023 | USA | 2018–2019 | 42,034 | NR | NR | NR | Ulceration Tumor staging Histological subtype |
2020 | 17,984 |
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Pellegrini, C.; Caini, S.; Gaeta, A.; Lucantonio, E.; Mastrangelo, M.; Bruni, M.; Esposito, M.; Doccioli, C.; Queirolo, P.; Tosti, G.; et al. Impact of COVID-19 Pandemic on Delay of Melanoma Diagnosis: A Systematic Review and Meta-Analysis. Cancers 2024, 16, 3734. https://doi.org/10.3390/cancers16223734
Pellegrini C, Caini S, Gaeta A, Lucantonio E, Mastrangelo M, Bruni M, Esposito M, Doccioli C, Queirolo P, Tosti G, et al. Impact of COVID-19 Pandemic on Delay of Melanoma Diagnosis: A Systematic Review and Meta-Analysis. Cancers. 2024; 16(22):3734. https://doi.org/10.3390/cancers16223734
Chicago/Turabian StylePellegrini, Cristina, Saverio Caini, Aurora Gaeta, Eleonora Lucantonio, Mirco Mastrangelo, Manfredo Bruni, Maria Esposito, Chiara Doccioli, Paola Queirolo, Giulio Tosti, and et al. 2024. "Impact of COVID-19 Pandemic on Delay of Melanoma Diagnosis: A Systematic Review and Meta-Analysis" Cancers 16, no. 22: 3734. https://doi.org/10.3390/cancers16223734
APA StylePellegrini, C., Caini, S., Gaeta, A., Lucantonio, E., Mastrangelo, M., Bruni, M., Esposito, M., Doccioli, C., Queirolo, P., Tosti, G., Raimondi, S., Gandini, S., & Fargnoli, M. C. (2024). Impact of COVID-19 Pandemic on Delay of Melanoma Diagnosis: A Systematic Review and Meta-Analysis. Cancers, 16(22), 3734. https://doi.org/10.3390/cancers16223734