A reduction in gaseous pollutants is an important method for mitigating PM
2.5 concentration in the atmosphere, and the reduction in SO
2/NH
3/NO
x is beneficial to control secondary inorganic aerosols in PM
2.5. In this study, the Weather Research and Forecasting model with Chemistry model (WRF-Chem) was applied to study the impact on the PM
2.5 and its secondary inorganic aerosols using the scenario simulation method in the Beijing–Tianjin–Hebei (BTH) region. The results showed that the BTH region is characterized by being NH
3-rich and having a higher [NH
4+]/[SO
42−] ratio in southern BTH, with a ratio of more than 6.0. Source contribution to PM
2.5 was highest in the 30%_SO
2_40%_NH
3_40%_NO
x scenario, with a contribution ratio of 6.8%, followed by 3.8% contribution in the 30%_SO
2_40%_NH
3 scenario, and a 3.4% contribution in the 30%_SO
2_60%_NH
3_60%_NO
x scenario. These results indicate that synergistic reduction measures may be suitable for controlling PM
2.5 concentrations. A lower sensitivity factor, β value between PM
2.5 and NH
3 suggests that solely reducing NH
3 emissions is not beneficial for the BTH region. However, this study indicates that the sensitivity of NO
3− would improve significantly if NH
3 emissions are reduced sharply. A slight reduction in NH
3 was found to be beneficial for controlling NO
3− in medium and small cities, while a significant decrease in NH
3 would be more suitable for mega-cities. The study also observed that SO
42− and its constituents continued to decrease with a consistent β value of approximately 0.14 in the 30%_SO
2_%_NH
3 scenario and between 10.5 and 12.8 in the 30%_SO
2_%_NH
3_%_NO
x scenario. These findings suggest that a synergistic reduction in SO
2-NH
3-NO
x emissions may be more effective in reducing PM
2.5 concentrations and its secondary inorganic aerosols (SIAs). However, it is important to ensure that the reduction in NH
3 and NO
x exceeds 60% in low SO
2 concentration conditions.
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