Epidemiology and Clinical Course of Haemorrhagic Fever with Renal Syndrome in New Endemic Area for Hantavirus Infection in Croatia
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Demographic Data, Clinical Presentation and Laboratory Parameters in Patients with HFRS * | |||
---|---|---|---|
Category | Values | Median | Ref. Values |
sex | male 156 (79%) female 42 (21%) | ||
age | 15–87 years | 45.74 | |
symptoms reported | |||
duration of symptoms | 2–21 days | 4.84 | |
highest body temperature | 37.4–40.0 °C | 38.07 | |
lumbar pain | 92 (46%) | ||
headache | 109 (55%) | ||
blurred vision | 45 (18%) | ||
myalgia | 78 (39%) | ||
vomiting | 61 (30%) | ||
laboratory results | |||
leukocyte count | 2.4–17.5 × 109/L | 6.84 | 3.4–9.7 × 109/L |
lowest platelets | 6–287 × 109/L | 89.97 | 158–424 × 109/L |
C-reactive protein | 7–246.8 mg/L | 89.31 | 0–5 mg/L |
creatinine | 44–839 umol/L | 176.17 | 49–90 umol/L |
serological testing | |||
Puumala IgM | 192 (97%) | ||
Dobrava IgM | 2 (1%) | ||
Puumala IgM+ and Dobrava IgM+ | 4 (2%) | ||
clinical course and outcome | |||
mild/moderate clinical course | 180 (91%) | ||
severe renal impairment with hemodialysis request | 3 (1.5%) | ||
hypotension and shock | 12 (6%) | ||
death | 3 (1.5%) |
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Cekinović Grbeša, Đ.; Zahirović, N.; Flego, V.; Livajić, M.; Rončević Filipović, M.; Knežević, S.; Slavuljica, I. Epidemiology and Clinical Course of Haemorrhagic Fever with Renal Syndrome in New Endemic Area for Hantavirus Infection in Croatia. Life 2023, 13, 1767. https://doi.org/10.3390/life13081767
Cekinović Grbeša Đ, Zahirović N, Flego V, Livajić M, Rončević Filipović M, Knežević S, Slavuljica I. Epidemiology and Clinical Course of Haemorrhagic Fever with Renal Syndrome in New Endemic Area for Hantavirus Infection in Croatia. Life. 2023; 13(8):1767. https://doi.org/10.3390/life13081767
Chicago/Turabian StyleCekinović Grbeša, Đurđica, Nino Zahirović, Viktorija Flego, Marija Livajić, Mari Rončević Filipović, Samira Knežević, and Irena Slavuljica. 2023. "Epidemiology and Clinical Course of Haemorrhagic Fever with Renal Syndrome in New Endemic Area for Hantavirus Infection in Croatia" Life 13, no. 8: 1767. https://doi.org/10.3390/life13081767
APA StyleCekinović Grbeša, Đ., Zahirović, N., Flego, V., Livajić, M., Rončević Filipović, M., Knežević, S., & Slavuljica, I. (2023). Epidemiology and Clinical Course of Haemorrhagic Fever with Renal Syndrome in New Endemic Area for Hantavirus Infection in Croatia. Life, 13(8), 1767. https://doi.org/10.3390/life13081767