The Image Quality and Diagnostic Performance of CT with Low-Concentration Iodine Contrast (240 mg Iodine/mL) for the Abdominal Organs
Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Korea
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(3), 752; https://doi.org/10.3390/diagnostics12030752
Submission received: 18 February 2022
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Revised: 11 March 2022
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Accepted: 17 March 2022
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Published: 19 March 2022
(This article belongs to the Special Issue Radiocontrast Media: Adverse Reactions and Side Effects)
Abstract
:Purpose: To evaluate the difference between CT examinations using 240 mgI/mL contrast material (CM) and 320 mgI/mL CM in the contrast enhancement of the abdominal organs and the diagnostic performance for focal hepatic lesions. Materials and methods: This retrospective study included 422 CT examinations, using 240 mgI/mL iohexol (Group A, 206 examinations) and 320 mgI/mL ioversol (Group B, 216 examinations), performed between April 2019 and May 2020. Two CT scanners (single-source CT (machine A) and dual-source CT (machine B)) were used to obtain CT images. Two radiologists independently drew regions of interest (ROIs) in the liver, pancreas, spleen, kidney, aorta, portal vein, and paraspinal muscle. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated for each organ. They evaluated the degree of subjective enhancement of the organs and detected/differentiated focal hepatic lesions. Results: The SNR, CNR, and subjective enhancement of most organs were significantly higher in Group B than in Group A (p < 0.05). The sensitivity and specificity for cysts and malignancy were higher than 85.0% in both groups. The sensitivity for hemangioma was lower in Group B (<75%) than in Group A. In Group A, the SNR and CNR were significantly higher in most organs with machine B than with machine A. Conclusion: Although the SNR and CNR of the abdominal organs were lower with 240 mgI/mL CM than with 320 mgI/mL CM, 240 mgI/mL CM was feasible for evaluating the liver. A CT scanner with more advanced specifications may be beneficial for examinations with 240 mgI/mL CM by using lower tube voltage.
1. Introduction
CT examinations are widely used for diagnosis or patient follow-up. As the diagnostic performance of contrast-enhanced CT is superior to that of unenhanced CT, intravenous iodinated contrast material (CM) is frequently used. A disadvantage of using iodine CM is the risk of contrast-induced nephropathy (CIN) [1,2,3]. Even though the incidence of CIN was low in patients with normal renal function or mild renal insufficiency [4,5,6], elevated serum creatinine levels before CT examination and known renal disease are risk factors for CIN due to intravenous iodine CM [5,7,8]. CIN is associated with increased mortality, and a high cumulative volume of iodine CM for patients with acute kidney injury was associated with poor renal outcome [9,10]. Moreover, the iodine load of patients is associated with the risk of CIN [11,12]. Therefore, the smallest possible dose of CM is recommended to minimize the risk of CIN [1,3,13].
We can reduce the total amount of CM or the concentration of CM to decrease the total amount of iodine. Several studies have shown the difference in hepatic enhancement between two concentrations of CM. Comparable enhancement was observed in the liver with two different concentrations (300 mgI/mL vs. 370 mgI/mL) of the same CM when the total iodine load was fixed [14,15,16]. However, other studies showed that mean hepatic enhancement was significantly better with 370 mgI/mL CM than with 300 mgI/mL CM when the total volume of CM was fixed [17,18]. In the pancreas, a higher dose of CM increased the maximum enhancement [19]. It seems that enhancement is affected by the total amount of iodine rather than the concentration of CM. However, radiologists may hesitate to use CM with a lower iodine concentration because the reduction in iodine load may affect diagnostic performance. Some studies showed that 240 mgI/mL CM was feasible for CT urography [20,21]. We questioned to what extent the use of 240 mgI/mL CM affected the contrast enhancement of the abdominal organs in routine abdominal CT. The purpose of this study was to evaluate the difference between CT examinations using 240 mgI/mL CM and 320 mgI/mL CM in the enhancement of the abdominal organs and the diagnostic performance for focal hepatic lesions.
2. Materials and Methods
2.1. Subjects
As the feasibility of 240 mgI/mL CM had not yet been proven for abdominal CT many organs with similar density, we could not use 240 mgI/mL CM for abdominal CT. However, 240 mgI/mL CM had been used for chest CT in our institution because the lung and mediastinal structures have very obvious contrast. Therefore, we evaluated the abdominal organs included in chest CT. Chest CT examinations performed between April 2019 and May 2020 were eligible for inclusion in this study. To cross-compare the image quality according to the CM and CT equipment, we searched patients with CT scans using different CMs (240 mgI/mL iohexol (Iobrix 240, Taejoon pharm., Seoul, Korea) and 320 mgI/mL ioversol (Optiray 320, Guerbet, Villepinte, France)) and the same machine or CT scans performed on different machines with the same CM. Both iohexol and ioversol are low osmolar CM. CT examinations were divided into two groups according to the concentration of the CMs: Group A with 240 mgI/mL and Group B with 320 mgI/mL. A total of 422 CT examinations (Group A: 206 examinations, Group B: 216 examinations) were included in this study. Clinical information such as age, sex, body weight, and height were collected from electronic medical records. Radiation dose-related information, including tube voltage, tube current, volume computed tomography dose index (CTDIvol) and dose length product (DLP), was collected from CT dose reports. The volume of CM that was used in each examination was recorded in the examination. We collected the information to calculate the amount of iodine.
2.2. CT Protocol
CT examinations were performed with two different CT machines: “machine A” was a 128-slice single-source CT scanner (Somatom Edge, Siemens Healthineers, Erlangen, Germany) with available tube potential 70–140 kVp and 20–800 mA, and “machine B” was a dual-source 384-slice (2 × 192) CT (Somatom Force, Siemens Healthineers, Erlangen, Germany) with available tube potential 70–150 kVp and 20–1300 mA. CT images were obtained 55 s after CM injection (1.4 mL/kg, 2 mL/sec) and 20 mL saline flush with a power injector (Medrad injector, Medrad, Warrendale, PA, USA) via the antecubital vein. As the same amount of CM per kg was used for both CMs, the iodine amount per kg in groups A and B was 336 mg/kg and 448 mg/kg. The acquisition parameters were similar for both machines: slice thickness 3 mm with a 3-mm interval; rotation time, 0.5 s; pitch, 1; automated tube voltage modulation (CARE kV, Siemens Healthineers) with reference kV 120; automatic tube current selection (CAREDose 4D, Siemens Healthineers) with reference mAs 130; collimation 128 × 0.6 for machine A and 192 × 0.6 for machine B.
2.3. Image Analysis
Two radiologists with more than 10 years of experience with abdominal radiology independently evaluated the chest CT images that were reconstructed with soft kernel (Br40). For quantitative analysis, they identified seven regions of interest (ROIs) in the liver, pancreas, spleen, kidney, aorta, portal vein, and paraspinal muscle. It was recommended that the size of the ROI be 2 cm2 or larger in the liver, spleen, and paraspinal muscle and as large as possible in the other organs on the single axial image that contained the largest area of each organ (Figure 1). They drew ROIs in the renal cortex avoiding the medulla to evaluate the kidney and in the paraspinal muscle area that showed the most homogeneous density. From the ROI, the mean density and standard deviation (aka noise) were extracted. The signal-to-noise ratio (SNR) was calculated as the mean density/standard deviation in each organ. The contrast-to-noise ratio (CNR) relative to muscle was calculated as (mean density of the organ–mean density of the paraspinal muscle)/standard deviation of the paraspinal muscle.
The same radiologists also performed a qualitative image analysis without any information about the CT parameters or clinical data. They subjectively evaluated the degree of contrast enhancement in the liver, pancreas, spleen, portal vein, aorta, and kidney and the overall noise of the images using a 5-point scale (1, very poor; 2, poor; 3, moderate; 4, good; 5, excellent). The two radiologists independently determined the presence of focal hepatic lesions and differentiated the lesions among cysts, hemangiomas, and malignancies. The final diagnosis was determined after discrepancies were resolved by consensus reading. They also predicted which CM would have been used for each examination.
2.4. Statistical Analysis
The interobserver agreement between the two radiologists who assessed the quantitative and qualitative analysis results was evaluated with intraclass correlation coefficient (ICC).
The patient’s characteristics and CT-related factors, such as radiation exposure and the amount of iodine, were compared between Groups A and B using the Fisher’s exact tests for categorical variables and the Student’s t-test for continuous variables. The mean values of the two readers were used to assess the quantitative and qualitative analysis results. The differences in the quantitative and qualitative parameters between the two groups were analyzed using the Student’s t-test. Additionally, the differences in the image quality between the CT machines and tube voltage (≤90 kVp vs. ≥100 kVp) in each group were evaluated using the Student’s t-test.
The interobserver agreement between the two radiologists, regarding the diagnosis, was analyzed for the entire examination and the two groups using the Kappa values. The sensitivity and specificity were calculated to detect the lesions. The agreement between the CM that was estimated by the radiologist and the CM that was used was also analyzed by the Kappa values. The Kappa value and ICC were interpreted as follows: <0.40, poor; 0.40≤ and <0.60, fair; 0.60≤ and <0.80, good; and 0.81–1.00, excellent agreement.
The institutional review board of our hospital approved this study and waived the requirement for informed consent due to the retrospective study design.
3. Results
There were no significant differences in the patients’ characteristics and the CT examinations between the two groups (Table 1). Tube voltage and CTDIvol were significantly higher in Group A than Group B.
The interobserver agreement for the mean density, which was a factor of quantitative analysis, and subjective degree of enhancement in the abdominal organs is summarized in Table 2. Quantitative analysis showed good agreement in all the organs except the portal vein, which showed poor agreement. The interobserver agreement, for the subjective degree of enhancement in the liver, portal vein, aorta, and kidney, was good.
In the quantitative analysis, the SNR was significantly higher in the spleen, portal vein, aorta, and the kidney in Group B than in Group A (Table 3). The CNR of all the organs except the liver was higher in Group B than in Group A. Subjective enhancement in all the organs was higher in Group B than in Group A (Table 4). The subjective noise level was not different between the two groups.
In each group, some quantitative parameters were significantly different between the machines that performed CT examinations (Figure 2). In Group A, the SNR of all the organs and the CNR of all the organs except the liver were significantly higher with machine B than machine A. In Group B, the SNR of the pancreas, spleen, and kidney and the CNR of the pancreas, spleen, and portal vein were significantly higher with machine B than machine A. The machine A frequently selected tube voltage 100 kVp or higher than machine B with statistical significance (Group A: 93.6% vs. 47.4%, p < 0.001; Group B: 83.3% vs. 40.2%, p < 0.001). All quantitative analysis parameters were significantly higher in CT scans with lower tube voltage than those with higher tube voltage in both groups (Table 5).
A total of 212 focal hepatic lesions, including 134 cysts, 25 hemangiomas, and 53 malignant lesions, were detected in all the examinations. The interreader agreement was fair to excellent for three diagnoses. The Kappa values between the two radiologists to detect cyst, hemangioma, and malignancy were 0.802, 0.712, and 0.935 in all the examinations, 0.796, 0.808, and 0.905 in Group A and 0.808, 0.610, and 0.923 in Group B. Compared to the gold standard, sensitivity was lowest for the hemangiomas by both readers in Group B (Table 6). Sensitivity to detect cysts was lower by reader 1 and higher by reader 2 in Group A than in Group B. Specificity was higher than 98% for three diagnoses by both readers. CT images of the representative patient who underwent CT scans using two different CMs are shown in Figure 3.
Reader 1 and reader 2 correctly guessed the CM in 42.2% (87/216) and 39.4% (85/216) of examinations in Group A and 80.6% (174/216) and 80.1% (173/216) in Group B.
4. Discussion
The feasibility of the low-iodine-concentration (240 mgI/mL) CM for the abdominal organs was evaluated in this study. The SNR and CNR of many abdominal organs were significantly higher in the CT examinations with 320 mgI/mL CM (Group B) than in those with 240 mgI/mL CM (Group A). Qualitative analysis also showed similar results that subject enhancement of the organs was significantly higher in Group B than Group A. As we used the same volume of CM per kg with different concentrations, which means the different iodine amounts per kg, in the two groups, the differences in the enhancement of the abdominal organs were noted as previously reported [17,18]. Low-iodine-concentration CM may have influenced the detection of hepatic focal lesions, but there was no difference in this study. Even though the SNR and CNR of most organs were higher in Group B than in Group A, the liver SNR and CNR were not different between the two groups, which may be the reason for the lack of significant differences in the diagnostic performance for the liver lesion.
Sensitivity and specificity were acceptable for the cyst, hemangioma, and malignancy in both groups. Rather, the sensitivity of hemangioma was lower in Group B than in Group A for both readers. The timing of a CT scan and a multiphase CT is important to accurately detect hemangiomas in the liver. Meanwhile, a decrease in enhancement may affect the detection of focal lesions such as hepatocellular carcinoma, and arterial enhancement is important. However, it may have less effect on the detection of low-density lesions that were mainly analyzed in this study. Therefore, it seems that low-concentration contrast agents can be used in patients who frequently undergo follow-up CT examinations for malignancy except for hepatocellular carcinoma, in which arterial enhancement is important.
As we did not adjust the CT parameters for the low-iodine-concentration CM, more prominent enhancement by using a lower tube voltage could not be achieved in this study. In a study of 270 mgI/mL CM in the liver, using a lower tube voltage (80 kVp) improved hepatic enhancement [22]. Usually, low tube voltage and advanced reconstruction techniques, such as iterative reconstruction, are used to compensate for the weak enhancement of low-concentration CM or to decrease iodine load [23,24]. Although there was no study that evaluated the image quality of the abdominal organs with 240 mgI/mL CM, several studies showed the feasibility of 240 mgI/mL CM in CT angiography and CT urography [20,21,25]. In these studies, better or comparable image quality was observed in the iteratively reconstructed CT examinations with low-tube-voltage and low-iodine-concentration CM than conventional CT examinations. In this study, as we did not change any CT parameters for the examinations in Group A, the SNR or CNR of most organs was different between the two groups. However, the subjective level of noise was not different between the two groups.
We evaluated the accuracy rate between the concentration of CM that radiologists predicted to have used in the CT and the actual concentration of CM used in the CT. Even though quantitative and qualitative analysis showed significant differences in many parameters between the CT images with 240 mgI/mL CM and 320 mgI/mL CM, radiologists could correctly estimate the CM only in approximately 40% in Group A. Both radiologists assumed that 320 mgI/mL would be used in more than half of the CT examinations with 240 mgI/mL. These results showed that 240 mgI/mL can obtain a level of contrast enhancement that can be recognized similarly to that of 320 mgI/mL CM.
In this study, we also analyzed the difference in image quality between the machines. The SNR and CNR were significantly improved in the CT examinations with machine B compared with machine A, especially for CT scans with 240 mgI/mL. The wider range of available tube voltage and tube current of machine B than machine A and differences in the detector may be the reason for the significant differences between the two machines. The differences in the image quality according to the CT machine have been reported previously [26,27,28,29]. Although automatic tube voltage selection and automatic tube current modulation could affect the image quality, both techniques were applied with similar settings in both machines in this study [29,30,31]. However, a more specific analysis of the difference between the two machines revealed that machine B chose lower kVp (≤90 kVp) with a significantly higher frequency than machine A. Additionally, SNR and CNR were significantly higher in CT examinations with lower kVp than with higher kVp, similar to previous studies [23,32,33,34]. We infer from these results that the CT with more advanced specifications, including advanced tubes and detectors, may be beneficial to improve the image quality of the CT with low-iodine-concentration CM by using lower kVp frequently.
There are several limitations in this study. First, we used chest CT in this study. As contrast-enhanced chest CT and abdominal CT are usually obtained with different time delays after CM injection, chest CT images cannot completely reflect abdominal CT. However, as we used the images that were reconstructed using the same soft tissue kernel that was used for the abdominal CT, the texture of the CT images was similar to that of the abdominal CT images. Second, we did not change the CT parameters to improve the enhancement when we used 240 mgI/mL. Many previous studies used low tube voltage to compensate for low-concentration CM [23,32,33,34]. Nevertheless, since various tube voltages were used in CT examinations by the automatic tube voltage selection, we could compare the differences in image quality according to tube voltage A prospective study is helpful to show the change in the quantitative parameters from the combination of low-iodine-concentration CM and low tube voltage in portal phase abdominal CT. Third, we evaluated diagnostic performance only in the liver. We cannot guarantee that detecting focal lesions in other abdominal organs, such as the pancreas and kidneys, is not affected by the concentration of CM. This should be revealed in future studies.
In conclusion, although the SNR and CNR of the abdominal organs were lower with 240 mgI/mL CM than with 320 mgI/mL CM, 240 mgI/mL CM was feasible for evaluating the liver. A CT scanner with more advanced specifications may be beneficial for examinations with 240 mgI/mL CM.
Author Contributions
Conceptualization, Y.-J.L. and S.-E.J.; Formal analysis, M.-H.C.; Investigation, M.-H.C. and Y.-J.L.; Methodology, M.-H.C. and S.-E.J.; Visualization, M.-H.C.; Writing—original draft, M.-H.C. and Y.-J.L.; Writing—review and editing, M.-H.C., Y.-J.L. and S.-E.J. All authors have read and agreed to the published version of the manuscript.
Funding
This work was supported by a Research Fund from TAEJOON PHARM Co., Ltd. Korea. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Institutional Review Board Statement
The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board of Eunpyeong St. Mary’s Hospital, the Catholic University of Korea (Protocol number PC20RISI0092, approval date 2 July 2020).
Informed Consent Statement
Requirement for informed consent due to the retrospective study design.
Data Availability Statement
The data presented in this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical concerns.
Conflicts of Interest
M.H.C. is currently receiving a research grant from Siemens Healthineers for the topic not related to the current research. For the remaining authors, none were declared.
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Figure 1.
Quantitative analysis of the CT images A radiologist draws multiple regions of interest in the liver, pancreas, spleen, portal vein, and aorta (a) and in the kidney and paraspinal muscle (b).
Figure 1.
Quantitative analysis of the CT images A radiologist draws multiple regions of interest in the liver, pancreas, spleen, portal vein, and aorta (a) and in the kidney and paraspinal muscle (b).
Figure 2.
Differences in the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) between the two machines in each group SNR and CNR of the organs in Group A (a,b) and Group B (c,d), respectively. * p < 0.05; ** p < 0.01; *** p < 0.001.
Figure 2.
Differences in the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) between the two machines in each group SNR and CNR of the organs in Group A (a,b) and Group B (c,d), respectively. * p < 0.05; ** p < 0.01; *** p < 0.001.
Figure 3.
A 64-year-old female patient who underwent CT examinations using the same machine (machine B). An approximately 0.7-cm cyst is noted in liver segment 8 on both CT examinations with 240 mgI/mL contrast material (a) and 320 mgI/mL contrast material (b).
Figure 3.
A 64-year-old female patient who underwent CT examinations using the same machine (machine B). An approximately 0.7-cm cyst is noted in liver segment 8 on both CT examinations with 240 mgI/mL contrast material (a) and 320 mgI/mL contrast material (b).
Table 1.
Baseline characteristics of the patients.
| All Examinations | Group A | Group B | p Value | |
|---|---|---|---|---|
| Age (years) | 65.9 ± 12.4 | 60.1 ± 12.0 | 65.8 ± 12.7 | 0.821 |
| Height (cm) | 160.7 ± 9.1 | 160.9 ± 9.3 | 160.4 ±8.9 | 0.573 |
| Weight (kg) | 59.1 ± 12.5 | 59.2 ± 12.7 | 59.1 ± 12.3 | 0.962 |
| CT machine (n) | ||||
| Somatom Edge | 223 | 109 | 114 | 0.978 |
| Somatom Force | 199 | 90 | 109 | |
| Tube voltage (kVp) | 97.2 ± 8.9 | 98.3 ± 8.4 | 96.1 ± 9.2 | 0.011 |
| Tube voltage ≤ 90 kVp | 138 | 58 | 80 | 0.062 |
| Tube current (mAs) | 163.6 ± 54.2 | 163.9 ± 45.6 | 163.3 ± 61.3 | 0.907 |
| CTDIvol (mGy) | 5.8 ± 2.0 | 6.0 ± 2.0 | 5.5 ± 2.1 | 0.014 |
| DLP (mGy cm) | 214.7 ± 84.6 | 221.2 ± 81.4 | 208.6 ± 87.4 | 0.126 |
| Iodine amount (g) | 25.6 ± 5.0 | 23.2 ± 3.9 | 27.9 ± 4.9 | <0.001 |
CTDIvol, volume CT dose index; DLP, dose length product.
Table 2.
Interreader agreement (intraclass correlation coefficient with 95% confidence interval) in the quantitative and qualitative image analysis parameters.
Table 2.
Interreader agreement (intraclass correlation coefficient with 95% confidence interval) in the quantitative and qualitative image analysis parameters.
| Quantitative Analysis: Mean Density | Qualitative Analysis: Enhancement | |
|---|---|---|
| Liver | 0.763 (0.713–0.805) | 0.674 (0.602–0.731) |
| Pancreas | 0.673 (0.604–0.703) | 0.485 (0.376–0.574) |
| Spleen | 0.758 (0.706–0.800) | 0.490 (0.382–0.579) |
| Portal vein | 0.266 (0.112–0.394) | 0.802 (0.761–0.837) |
| Aorta | 0.753 (0.701–0.796) | 0.657 (0.585–0.717) |
| Kidney | 0.671 (0.602–0.728) | 0.680 (0.613–0.736) |
Table 3.
Quantitative image analysis in both groups according to the concentration of contrast material.
Table 3.
Quantitative image analysis in both groups according to the concentration of contrast material.
| Group A (240 mgI/mL) | Group B (320 mgI/mL) | p Value | |
|---|---|---|---|
| SNR | |||
| Liver | 7.0 ± 1.8 | 6.8 ± 1.8 | 0.324 |
| Pancreas | 6.4 ± 1.7 | 6.4 ± 1.9 | 0.958 |
| Spleen | 9.6 ± 2.4 | 10.2 ± 2.8 | 0.022 |
| Portal vein | 9.2 ± 2.8 | 9.8 ± 2.9 | 0.036 |
| Aorta | 15.3 ± 4.5 | 17.0 ± 4.9 | <0.001 |
| Kidney | 10.9 ± 3.0 | 11.5 ± 3.3 | 0.033 |
| CNR | |||
| Liver | 2.4 ± 1.4 | 2.6 ± 1.7 | 0.221 |
| Pancreas | 3.1 ± 1.7 | 3.6 ± 2.1 | 0.002 |
| Spleen | 5.1 ± 2.7 | 6.1 ± 2.9 | <0.001 |
| Portal vein | 7.2 ± 4.2 | 8.6 ± 5.5 | 0.002 |
| Aorta | 13.0 ± 5.1 | 15.1 ± 5.3 | <0.001 |
| Kidney | 7.7 ± 3.1 | 9.1 ± 3.7 | <0.001 |
SNR, signal-to-noise ratio; CNR, contrast-to-noise ratio.
Table 4.
Qualitative analysis in both groups according to the concentration of contrast material.
| Group A (240 mgI/mL) | Group B (320 mgI/mL) | p Value | |
|---|---|---|---|
| Subjective enhancement | |||
| Liver | 4.5 ± 0.6 | 4.8 ± 0.4 | <0.001 |
| Pancreas | 4.9 ± 0.3 | 5.0 ± 0.2 | <0.001 |
| Spleen | 4.9 ± 0.3 | 5.0 ± 0.2 | <0.001 |
| Portal vein | 4.3 ± 0.7 | 4.6 ± 0.6 | <0.001 |
| Aorta | 4.9 ± 0.3 | 4.9 ± 0.2 | <0.001 |
| Kidney | 4.6 ± 0.5 | 4.9 ± 0.3 | <0.001 |
| Noise | 3.6 ± 0.6 | 3.7 ± 0.5 | 0.225 |
Table 5.
Differences in quantitative image analysis between lower and higher tube voltage.
| Group A (240 mgI/mL) | Group B (320 mgI/mL) | |||||
|---|---|---|---|---|---|---|
| ≤90 kVp | ≥100 kVp | p Value | ≤90 kVp | ≥100 kVp | p Value | |
| SNR | ||||||
| Liver | 7.8 ± 2.1 | 6.6 ± 1.5 | <0.001 | 7.1 ± 2.0 | 6.6 ± 1.6 | 0.043 |
| Pancreas | 7.0 ± 2.1 | 6.1 ± 1.5 | 0.004 | 6.9 ± 2.0 | 6.1 ± 1.8 | 0.004 |
| Spleen | 10.8 ± 2.8 | 9.2 ± 2.0 | <0.001 | 11.1 ± 3.3 | 9.7 ± 2.4 | 0.002 |
| Portal vein | 10.6 ± 3.5 | 9.6 ± 2.3 | <0.001 | 10.8 ± 3.3 | 9.1 ± 2.5 | <0.001 |
| Aorta | 17.7 ± 5.4 | 14.3 ± 3.6 | <0.001 | 18.7 ± 5.5 | 16.0 ± 4.2 | <0.001 |
| Kidney | 12.0 ± 3.9 | 10.4 ± 2.5 | 0.004 | 12.8 ± 3.7 | 10.8 ± 2.7 | <0.001 |
| CNR | ||||||
| Liver | 2.8 ± 1.3 | 2.2 ± 1.4 | 0.012 | 2.8 ± 1.8 | 2.4 ± 1.6 | 0.074 |
| Pancreas | 3.7 ± 2.8 | 2.8 ± 1.6 | <0.001 | 4.3 ± 2.2 | 3.2 ± 2.0 | <0.001 |
| Spleen | 6.2 ± 3.2 | 4.7 ± 2.3 | 0.002 | 6.8 ± 3.5 | 5.7 ± 2.4 | 0.016 |
| Portal vein | 8.6 ± 3.6 | 6.6 ± 4.2 | 0.003 | 10.8 ± 7.7 | 7.4 ± 2.9 | <0.001 |
| Aorta | 15.7 ± 6.0 | 12.0 ± 4.2 | <0.001 | 16.6 ± 6.1 | 14.1 ± 4.6 | 0.002 |
| Kidney | 9.2 ± 3.8 | 7.1 ± 2.5 | <0.001 | 10.5 ± 4.1 | 8.3 ± 3.1 | <0.001 |
SNR, signal-to-noise ratio; CNR, contrast-to-noise ratio.
Table 6.
Diagnostic performance in all the patients and in the two groups.
| Cyst | Hemangioma | Malignancy | |||||
|---|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | ||
| Reader 1 | Total | 91.0 | 99.3 | 80.0 | 99.2 | 100 | 99.5 |
| Group A | 87.5 | 100 | 90.0 | 99.0 | 100 | 99.5 | |
| Group B | 95.2 | 98.7 | 73.3 | 99.5 | 100 | 99.5 | |
| Reader 2 | Total | 85.8 | 99.7 | 80.0 | 99.7 | 94.3 | 99.7 |
| Group A | 88.9 | 99.3 | 100 | 99.5 | 100 | 99.5 | |
| Group B | 82.3 | 100 | 66.7 | 100 | 90.3 | 100 | |
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MDPI and ACS Style
Choi, M.-H.; Lee, Y.-J.; Jung, S.-E. The Image Quality and Diagnostic Performance of CT with Low-Concentration Iodine Contrast (240 mg Iodine/mL) for the Abdominal Organs. Diagnostics 2022, 12, 752. https://doi.org/10.3390/diagnostics12030752
AMA Style
Choi M-H, Lee Y-J, Jung S-E. The Image Quality and Diagnostic Performance of CT with Low-Concentration Iodine Contrast (240 mg Iodine/mL) for the Abdominal Organs. Diagnostics. 2022; 12(3):752. https://doi.org/10.3390/diagnostics12030752
Chicago/Turabian StyleChoi, Moon-Hyung, Young-Joon Lee, and Seung-Eun Jung. 2022. "The Image Quality and Diagnostic Performance of CT with Low-Concentration Iodine Contrast (240 mg Iodine/mL) for the Abdominal Organs" Diagnostics 12, no. 3: 752. https://doi.org/10.3390/diagnostics12030752
APA StyleChoi, M. -H., Lee, Y. -J., & Jung, S. -E. (2022). The Image Quality and Diagnostic Performance of CT with Low-Concentration Iodine Contrast (240 mg Iodine/mL) for the Abdominal Organs. Diagnostics, 12(3), 752. https://doi.org/10.3390/diagnostics12030752
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