The conflict of the political situations around the world, the intensification of economic, religious, and other social contradictions, and the outbreak of local wars, have led to more and more terrorist attacks. Terrorist attacks usually target some important buildings as the main target and carry out terrorist activities by placing or dropping explosives [
1]. According to the research results of the National Institute of Standards and Technology (NSIT), when the building structure is subjected to a bomb terrorist attack, 85% of the casualties are not caused by the bomb itself, but by the chain reaction of the collapse of the building structure. Therefore, it has become an urgent and important topic to study the damage factors affecting the RC frame structure under an internal explosion load.
Recently, many scholars have carried out a lot of work on the damage mechanism and damage influencing factors of RC frames under an explosion load. Xia et al. [
2] established a FEM considering the fluid–solid coupling effect on the explosive–air–structure relationship and studied the damage mechanism of the RC structure under an explosion load. Alina Fatima et al. [
3] simulated different types of blast loads using the finite element method and studied the damage effects of various types of blast loads on reinforced concrete frames. J.X. Lu et al. [
4] studied the damage to a reinforced concrete frame filled with masonry wall under a blast load using numerical simulation. The results showed that the existence of a masonry wall can reduce the damage to a reinforced concrete frame. Yanchao Shi et al. [
5] proposed a damage assessment method for a reinforced concrete frame under a blast load based on the substructure method. The results showed that this method can effectively predict the damage to a reinforced concrete frame under a near explosion. Chen Ou et al. [
6] studied the response of the remaining structure of the reinforced concrete frame after the column was subjected to an impact load. The results showed that the damage degree of the remaining structure may be related to the order of the column removal. Similarly, Fan Yi et al. [
7] also studied the failure response of reinforced concrete frames after the removal of impact loads on columns. The results showed that compared with direct removal, the removal of impact loads made the reinforced concrete frame more vulnerable to damage. Using numerical simulation, Zhou Jikai et al. [
8] studied the influence of parameters such as the location of the failed component, the size of the component, the reinforcement ratio, and the standoff distance on the overall progressive collapse behavior of the frame structure under an explosive load. Zhang [
9] studied the influence of different joint forms on the progressive collapse resistance of assembled reinforced concrete frame structures under a local explosion. The results showed that the progressive collapse resistance of assembled monolithic frame structures is better than that of fully assembled frame structures. Through numerical simulation, Yue [
10] studied the anti-explosion performance of reinforced concrete structures under a contact explosion. Kuang et al. [
11] used LS-DYNA to study the dynamic response of a three-story RC frame under blast loading, and analyzed the effects of the charge weight, section form, reinforcement arrangement, and reinforcement ratio on the structural response. M.Vaghefi et al. [
12] used LS-DYNA to study the damage to reinforced concrete bridges under blast loading. The results showed that when the TNT charge weight increased by 39%, the damage effect of the TNT explosion on the bridge deck increased by 100%. B. Mobaraki et al. [
13] also used LS-DYNA as a research tool to study the influence of soil type on the dynamic response of a tunnel under an explosion load. The results showed that when the soil type of the buried tunnel is silty clay sand, the damage to the tunnel under an explosion load is the least. Zhu Shengbo [
14] studied the failure mode of a reinforced concrete frame under a near explosion using Autodyn. The results showed that the damage to a reinforced concrete structure under an explosion mainly depends on the explosives. Kim et al. [
15] also studied the damage response of a reinforced concrete frame under an explosion load using Autodyn. The results showed that different reinforcement methods and stirrup spacing have different effects on the anti-explosion performance of a reinforced concrete frame. Ghada Mousa Hekal [
16] studied the influence of the lack of middle columns caused by an explosion on the progressive collapse of the reinforced concrete frame using Abaqus. The results showed that compared with the direct removal of components, the removal of components by an explosion load can predict the collapse of a frame structure more realistically. Baylot et al. [
17] carried out an experimental study on the internal and external explosion loads of a 1/4 scaled reinforced concrete frame structure and studied the influence of the external wall on the explosion load and response of the outer column of the structure. Gao et al. [
18] designed and fabricated a 1/8 scaled three-story RC frame structure model and studied the influence of different charge weights and detonation positions on the dynamic response and failure mode of the frame structure. Gong [
19] carried out an explosion test of a 1/2 scaled two-story RC frame structure and studied the influence of different charge weights and standoff distances on the dynamic response of the frame structure.
The damage mechanism and damage factors of an RC frame structure under an explosion load have attracted wide attention from scholars. However, research on the influence of various damage factors on an RC frame structure is still rarely conducted. Therefore, in this paper, the FEM of the RC frame is established using ANSYS/LS-DYNA finite element analysis software, and the influence of the four damage factors of the beam section reinforcement ratio, charge weight, explosion horizontal position, and explosion floor on the damage degree of the RC frame is analyzed. The variance analysis of the simulation results obtained by the orthogonal optimization design is carried out. The order of the influence degree of the four factors, such as the reinforcement ratio, charge weight, explosion horizontal position, and explosion floor, on the RC frame structure is obtained. The aim is to provide some references for the anti-explosion design and safety protection of an RC frame structure.