Worldwide Prevalence of mcr-mediated Colistin-Resistance Escherichia coli in Isolates of Clinical Samples, Healthy Humans, and Livestock—A Systematic Review and Meta-Analysis
, Jacobus H. de Waard 3, MarÃa Soledad Salgado 1, MarÃa José VillacÃs 1, Marco Coral-Almeida 3,*, Yoshimasa Yamamoto 4 and Manuel Calvopiña 3Round 1
Reviewer 1 Report
The study is well written and of very high interest.
I suggest to shorten the discussion and the section about study limitations.
In Line 200: You state that in Europe there are two mcr alleles detected, nevertheless in Figure 3 100% mcr-1 are shown.
Please strenghten already in the results that the study design is not appropriate for determining prevalence (since this highly depends on reporting).
Could you report on potential spread between continents? Is that possible from analysing mcr alleles? Or would you assume homoplasy events?
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Comments for author File: Comments.pdf
Author Response
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Author Response File: Author Response.pdf
