Temperature-Controlled Hyperthermia with Non-Invasive Temperature Monitoring through Speed of Sound Imaging
and Paul Carson 2
Round 1
Reviewer 1 Report
Dear Authors,
This manuscript proposes a temperature-controlled hyperthermia model that uses high intensity focused ultrasound for clinical tumor treatment, combined with diagnostic ultrasound image guidance and non-invasive temperature monitoring through speed of sound imaging. This study is interesting and well-written; however, I have some minor remarks:
- Abstract
--> You should mention the fact that your model involves the human thigh before stating that <<The inner structure information of thigh tissue is obtained by B-mode ultrasound imaging.>> This is the first reference of the thigh in the manuscript and should be more clear, otherwise, the readers won’t understand why the inner structure of the thigh is needed.
--> Please rephrase the following phrase <<This study verifies the feasibility of the proposed temperature-controlled hyperthermia model>> by giving a confirmation or a conclusion of your verification.
- Introduction:
--> The final paragraph of the introduction should only state the objectives of your study, not provide details regarding the model or the fact that it works, or it is effective. You should distribute this information in the other sections.
- Results:
--> The caption of Table 1 is too brief and should be better explained.
--> You defined three human thigh models with different muscle radius including 55.00mm, 60.00mm and 65.00mm. Have you performed any tests with various sizes of the tumor? (not only changing the position…)
- Discussion/Conclusions
--> Have you identified any limitations of your study?
--> The phrase related to the MATLAB implementation codes should be removed from Conclusions and placed in another section.
Best regards!
Comments for author File: 
Comments.docx
Author Response
Details are in the attached file.
Author Response File: Author Response.docx
Reviewer 2 Report
This work presents a proposal for hyperthermia therapy, it looks like a solid proposal, however I have noticed that the radii at which the simulation has been done are quite small 6cm, this is related to the tumour? or to the human body? as it is not invasive it limits this quite a lot for a clinical application, how do the authors believe that this can be applied in humans? make a discussion about this.
Author Response
Details are in the attached file.
Author Response File: Author Response.docx
