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Antioxidants
Volume 13
Issue 12
10.3390/antiox13121443
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage

by
Yi-Fen Chiang
1,†,
Yi-Tzu Chen
1,†,
Ko-Chieh Huang
1,
Wei-Lun Hung
2,
Cheng-Pei Chung
3,
Tzong-Ming Shieh
4,
Yun-Ju Huang
5,
Mohamed Ali
6,7 and
Shih-Min Hsia
1,2,8,9,10,*
1
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
2
School of Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
3
Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
4
School of Dentistry, College of Dentistry, China Medical University, Taichung 40402, Taiwan
5
Department of Biotechnology and Food Technology, Southern Taiwan University of Science and Technology, Tainan 710301, Taiwan
6
Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
7
Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA
8
Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
9
Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan
10
TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 110301, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2024, 13(12), 1443; https://doi.org/10.3390/antiox13121443 (registering DOI)
Submission received: 3 October 2024 / Revised: 10 November 2024 / Accepted: 21 November 2024 / Published: 23 November 2024
(This article belongs to the Special Issue Effect of Oxidative Stress on Reproduction and Development—2nd Edition)
Versions Notes

Abstract

Cisplatin (CIS) is a widely used chemotherapeutic agent, but its side effects, such as oxidative stress, inflammation, and apoptosis, often lead to male reproductive damage. Oxidative stress, primarily caused by the excessive generation of reactive oxygen species (ROS), plays a critical role in disrupting testicular homeostasis, resulting in spermatogenic impairment and tissue injury. L-cysteine (CYS), a semi-essential amino acid with potent antioxidant and anti-inflammatory properties, may offer protection against CIS-induced oxidative damage. This study aimed to assess the protective potential of CYS against CIS-induced male reproductive toxicity using in vivo and in vitro models. In vitro, treatment of TM3 (Leydig) and TM4 (Sertoli) cells with CIS led to increased ROS levels, reduced cell viability, and elevated apoptosis and inflammation, all of which were significantly ameliorated by subsequent CYS exposure. In vivo, CIS-treated male rats displayed heightened oxidative stress, impaired spermatogenesis, and histopathological damage in reproductive organs. However, CYS administration for 21 days significantly reduced oxidative stress, improved sperm viability, and protected testicular tissues from damage. These findings suggest that CYS has a protective effect against CIS-induced oxidative stress and male reproductive damage, making it a promising therapeutic agent for mitigating CIS-induced reproductive toxicity.
Keywords: cisplatin; L-cysteine; male reproductive damage; oxidative stress cisplatin; L-cysteine; male reproductive damage; oxidative stress

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MDPI and ACS Style

Chiang, Y.-F.; Chen, Y.-T.; Huang, K.-C.; Hung, W.-L.; Chung, C.-P.; Shieh, T.-M.; Huang, Y.-J.; Ali, M.; Hsia, S.-M. Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage. Antioxidants 2024, 13, 1443. https://doi.org/10.3390/antiox13121443

AMA Style

Chiang Y-F, Chen Y-T, Huang K-C, Hung W-L, Chung C-P, Shieh T-M, Huang Y-J, Ali M, Hsia S-M. Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage. Antioxidants. 2024; 13(12):1443. https://doi.org/10.3390/antiox13121443

Chicago/Turabian Style

Chiang, Yi-Fen, Yi-Tzu Chen, Ko-Chieh Huang, Wei-Lun Hung, Cheng-Pei Chung, Tzong-Ming Shieh, Yun-Ju Huang, Mohamed Ali, and Shih-Min Hsia. 2024. "Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage" Antioxidants 13, no. 12: 1443. https://doi.org/10.3390/antiox13121443

APA Style

Chiang, Y. -F., Chen, Y. -T., Huang, K. -C., Hung, W. -L., Chung, C. -P., Shieh, T. -M., Huang, Y. -J., Ali, M., & Hsia, S. -M. (2024). Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage. Antioxidants, 13(12), 1443. https://doi.org/10.3390/antiox13121443

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