Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
Abstract
:1. Introduction
2. Materials and Methods
2.1. Material
2.2. Development of o/w Emulsions and Stability Study
2.3. Sensorial Analysis
2.4. Production of Phytocosmetic and Stability Study
2.5. Zeta Potential
2.6. Droplet Size Distribution
2.7. Mechanical Analysis
2.8. Thermal Analysis
2.9. Microbiologic Control
2.10. In Vitro Sun Protection Factor (SPF) Evaluation of the Phytocosmetic
2.11. In Vitro Antioxidant Activity Analysis of the Phytocosmetic
2.12. Skin Permeation
2.13. Photostability Study
2.14. In Vitro Skin Irritation—Reconstructed Human Epidermis
2.15. Statistical Analysis
3. Results and Discussion
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Components (INCI NAME) | Concentration (%) | ||||||||
---|---|---|---|---|---|---|---|---|---|
F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | |
Tribehenin | 5.0 | 6.0 | 5.0 | 6.0 | - | - | 8.0 | 8.0 | - |
Sorbitan stearate and sucrose cocoate | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | - | - | 8.0 |
Sucrose palmitate glyceryl stearate and glyceryl stearate citrate and sucrose and manna and xanthan gum | 5.0 | 5.0 | 3.0 | 3.0 | 5.0 | 2.0 | 5.0 | 2.0 | 0.5 |
Caprylic and capric triglyceride | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 |
Hydrolyzed wheat protein and PVP cross-polymer | 3.0 | 3.0 | 5.0 | 5.0 | 3.0 | 2.0 | 3.0 | 2.0 | 2.0 |
Persea gratissima (Avocado) oil | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
Phenoxyethanol | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
Glycerin | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 |
Talc | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.5 | 1.5 | 1.5 |
Aqua | 72.0 | 71.0 | 72.0 | 71.0 | 77.0 | 81.0 | 76.5 | 80.5 | 82.0 |
Formulations | Rupture Strength (G) | Brittleness (mm) | Adhesiveness (g.s) | Firmness (G) |
---|---|---|---|---|
Plain emulsion | 3.62 ± 1.31 | 19.05 ± 0.76 | −50.18 ± 0.63 | 633.26 ± 0.11 |
Phytocosmetic | 3.07 ± 0.33 | 16.57 ± 2.90 | −43.01 ± 2.53 | 487.08 ± 0.15 |
Formulations | Enthalpy Variation | |
---|---|---|
Stage 1 (°C) | Stage 2 (°C) | |
Plain emulsion | 51.66 | 120.93 |
Phytocosmetic | 52.65 | 113.77 |
Formulation | TM (°C) Stage 1 | Weight Loss (%) | TM (°C) Stage 2 | Weight Loss (%) | TM (°C) Stage 3 | Weight Loss (%) |
---|---|---|---|---|---|---|
Plain emulsion | 87.89 | 86.64 | 167.83 | 3.94 | 278.22 | 4.21 |
Phytocosmetic | 82.76 | 79.87 | 166.97 | 4.53 | 273.20 | 5.82 |
Samples | Cell Viability (%) ± SD |
---|---|
Formulation with extracts | 104.6 ± 7.5 |
Negative control | 100.0 ± 2.9 |
Positive control | 1.1 ± 0.1 |
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Share and Cite
Cefali, L.C.; Ataide, J.A.; Fernandes, A.R.; Sousa, I.M.d.O.; Gonçalves, F.C.d.S.; Eberlin, S.; Dávila, J.L.; Jozala, A.F.; Chaud, M.V.; Sanchez-Lopez, E.; et al. Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties. Antioxidants 2019, 8, 443. https://doi.org/10.3390/antiox8100443
Cefali LC, Ataide JA, Fernandes AR, Sousa IMdO, Gonçalves FCdS, Eberlin S, Dávila JL, Jozala AF, Chaud MV, Sanchez-Lopez E, et al. Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties. Antioxidants. 2019; 8(10):443. https://doi.org/10.3390/antiox8100443
Chicago/Turabian StyleCefali, Letícia Caramori, Janaína Artem Ataide, Ana Rita Fernandes, Ilza Maria de Oliveira Sousa, Fernanda Cristina da Silva Gonçalves, Samara Eberlin, José Luis Dávila, Angela Faustino Jozala, Marco Vinicius Chaud, Elena Sanchez-Lopez, and et al. 2019. "Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties" Antioxidants 8, no. 10: 443. https://doi.org/10.3390/antiox8100443
APA StyleCefali, L. C., Ataide, J. A., Fernandes, A. R., Sousa, I. M. d. O., Gonçalves, F. C. d. S., Eberlin, S., Dávila, J. L., Jozala, A. F., Chaud, M. V., Sanchez-Lopez, E., Marto, J., d’Ávila, M. A., Ribeiro, H. M., Foglio, M. A., Souto, E. B., & Gava Mazzola, P. (2019). Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties. Antioxidants, 8(10), 443. https://doi.org/10.3390/antiox8100443