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Sci. Pharm.
Volume 70
Issue 2
10.3797/scipharm.aut-02-14
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Article

Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity.

by
Usifoh C. O.
1,* and
Ukoh G. C.
2
1
Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
2
Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(2), 123-128; https://doi.org/10.3797/scipharm.aut-02-14
Submission received: 8 January 2002 / Revised: 8 February 2002 / Accepted: 8 February 2002 / Published: 23 April 2002
Versions Notes

Abstract

The synthesis of a novel quinazolinone was accomplished by the reaction of quinazolin- 2,4-(1H,3H)-dione with trifluoromethanesulfonic anhydride in triethylamine. The antimicrobial activity was determined against eight microorganisms. The organisms were all susceptible to 3-(4-methoxyquinazolin-2-yl)-quinazolin-2,4-(1H,3H)-dione 3 at the concentrations used. The gram positive organisms showed more susceptibility than the gram negative ones.
Keywords: Quinazolinoe, Triflate, Antimicrobial activity Quinazolinoe, Triflate, Antimicrobial activity

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MDPI and ACS Style

C. O., U.; G. C., U. Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity. Sci. Pharm. 2002, 70, 123-128. https://doi.org/10.3797/scipharm.aut-02-14

AMA Style

C. O. U, G. C. U. Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity. Scientia Pharmaceutica. 2002; 70(2):123-128. https://doi.org/10.3797/scipharm.aut-02-14

Chicago/Turabian Style

C. O., Usifoh, and Ukoh G. C. 2002. "Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity." Scientia Pharmaceutica 70, no. 2: 123-128. https://doi.org/10.3797/scipharm.aut-02-14

APA Style

C. O., U., & G. C., U. (2002). Triflate-mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)- quinazolin-2,4-(1H,3H)-dione and its Antimicrobial Activity. Scientia Pharmaceutica, 70(2), 123-128. https://doi.org/10.3797/scipharm.aut-02-14

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