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Sci. Pharm.
Volume 72
Issue 4
10.3797/scipharm.aut-04-24
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Article

Synthesis, physico-chemical properties and bioloclical activitv of 1-(4-fluorophenvl)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl] piperaziniumchlorides

by
Ivan Malík
1,*,
Eva Sedlárová
1,
Jozef Csöllel
3,
Eva Račanská
2,
Jozef Čižmárik
1 and
Pavel Kurfürst
3
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia
2
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia
3
Institute of Chemical Drugs, University of Veterinary and Pharmacy, Palackého 1-3, 612 42 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(4), 283-291; https://doi.org/10.3797/scipharm.aut-04-24
Submission received: 6 May 2004 / Revised: 17 September 2004 / Accepted: 17 September 2004 / Published: 5 December 2004
Versions Notes

Abstract

1-(4-fluoropheny1)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl]piperaziniumchlorides, with one to four carbon atoms in the alkoxy group on aromatic ring have been synthesized as the derivatives of substituted phenylcarbamic acid. The structures were confirmed by their spectral data. Potential antiarrhythmic activity was evaluated in guinea-pigs model. Preliminary studies demonstrated that the evaluated compounds, using ouabain arrhythmia model, appear to possess only moderate antiarrhythmic activity. Only compound marked as 4f appears to be more potent and lead us to focus our attention on structures with more bulky substituent in the m-position at aromatic ring in the hydrophilic part of molecule.
Keywords: phenylcarbamic acid derivatives; antiarrhythmic activity phenylcarbamic acid derivatives; antiarrhythmic activity

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MDPI and ACS Style

Malík, I.; Sedlárová, E.; Csöllel, J.; Račanská, E.; Čižmárik, J.; Kurfürst, P. Synthesis, physico-chemical properties and bioloclical activitv of 1-(4-fluorophenvl)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl] piperaziniumchlorides. Sci. Pharm. 2004, 72, 283-291. https://doi.org/10.3797/scipharm.aut-04-24

AMA Style

Malík I, Sedlárová E, Csöllel J, Račanská E, Čižmárik J, Kurfürst P. Synthesis, physico-chemical properties and bioloclical activitv of 1-(4-fluorophenvl)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl] piperaziniumchlorides. Scientia Pharmaceutica. 2004; 72(4):283-291. https://doi.org/10.3797/scipharm.aut-04-24

Chicago/Turabian Style

Malík, Ivan, Eva Sedlárová, Jozef Csöllel, Eva Račanská, Jozef Čižmárik, and Pavel Kurfürst. 2004. "Synthesis, physico-chemical properties and bioloclical activitv of 1-(4-fluorophenvl)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl] piperaziniumchlorides" Scientia Pharmaceutica 72, no. 4: 283-291. https://doi.org/10.3797/scipharm.aut-04-24

APA Style

Malík, I., Sedlárová, E., Csöllel, J., Račanská, E., Čižmárik, J., & Kurfürst, P. (2004). Synthesis, physico-chemical properties and bioloclical activitv of 1-(4-fluorophenvl)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl] piperaziniumchlorides. Scientia Pharmaceutica, 72(4), 283-291. https://doi.org/10.3797/scipharm.aut-04-24

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