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Abstract

Long-Term Sunflower Oil Diet Effects on Mouse Brain Lipid Metabolism †

by
Slavica Rankovic
1,*,
Aleksandra Nenadovic
2,
Jasmina Debeljak Martacic
1,
Sanjin Kovacevic
2,
Jelena Milasin
3,
Tamara Popovic
1 and
Alexander Trbovich
2
1
Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia
2
School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
3
School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
†
Presented at the 14th European Nutrition Conference FENS 2023, Belgrade, Serbia, 14–17 November 2023.
Proceedings 2023, 91(1), 174; https://doi.org/10.3390/proceedings2023091174
Published: 1 February 2024
(This article belongs to the Proceedings of The 14th European Nutrition Conference FENS 2023)
Versions Notes

Abstract

:
Background and Objectives: Fatty acids play an important role in many physiological processes in different organs. Their effect is well documented in neurodegenerative diseases and inflammatory diseases. Also, the brain as an organ is known to be enriched by docosahexaenoic acid (DHA) and arachidonic acid (AA). However, there are not many studies showing the effect of long-term oil diets on brain lipid metabolism. The aim of this study was to investigate the effects of dietary sunflower oil (enriched with oleic acid, GA-ME-HA, Sarajevo, Bosnia and Hercegovina) on fatty acid profiles in the brain after 100 days of treatment. Methods: Six-week-old adult female C57BL/6 mice were used in these experiments. A total of 20 laboratory female C57BL/6 mice were randomly divided into two groups, the control (n = 10) and sunflower diet treatment groups (n = 10), enriched with 25% saturated/unsaturated fats in isocaloric diet conditions. Mice were obtained from the vivarium (Galenika a.d. Belgrade, Serbia) and housed at four or five animals per cage under identical and controlled conditions (temperature 22 ± 1 °C, humidity 65 ± 1%, 12 h circadian rhythm). Fatty acid ester analysis was performed by gas–liquid chromatography (Shimadzu, Kyoto, Japan) and presented as percentages of overall 100% fatty acids identified. Results: Our results showed that a sunflower oil diet increases DHA (p < 0.05) as well as arachidonic acid (AA) (p < 0.05). There was also a trend of increasing linoleic acid (LA), but it was not significant. Our future studies would perform more investigations.

Author Contributions

S.R., T.P. and J.D.M. have written the manuscript. T.P., A.N., J.D.M., S.R. and S.K. have conducted experiments. J.M. and A.T. have supervised the work. A.N. and T.P. have performed statistical analyses. All authors have been involved in interpreting the results, contributed to drafting the discussion, and approved the final version of the manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

This study was supported by grants No 175075, No III 41019, No III-45003 and 0000-0003-0333-2118 from the Ministry of Education, Science and Technological Development, Government of Serbia.

Institutional Review Board Statement

Experimental Animals Ethics Committee at the University of Belgrade, Faculty of Medicine (approval number 323-07-09403/2014-05/1, dated 13.11.2015). Additionally, we conducted all experiments following the ARRIVE guidelines and the National Research Council’s Guide for the Care and Use of Laboratory Animals.

Informed Consent Statement

Not applicable.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors on request.

Conflicts of Interest

The authors declare no conflict of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Rankovic, S.; Nenadovic, A.; Debeljak Martacic, J.; Kovacevic, S.; Milasin, J.; Popovic, T.; Trbovich, A. Long-Term Sunflower Oil Diet Effects on Mouse Brain Lipid Metabolism. Proceedings 2023, 91, 174. https://doi.org/10.3390/proceedings2023091174

AMA Style

Rankovic S, Nenadovic A, Debeljak Martacic J, Kovacevic S, Milasin J, Popovic T, Trbovich A. Long-Term Sunflower Oil Diet Effects on Mouse Brain Lipid Metabolism. Proceedings. 2023; 91(1):174. https://doi.org/10.3390/proceedings2023091174

Chicago/Turabian Style

Rankovic, Slavica, Aleksandra Nenadovic, Jasmina Debeljak Martacic, Sanjin Kovacevic, Jelena Milasin, Tamara Popovic, and Alexander Trbovich. 2023. "Long-Term Sunflower Oil Diet Effects on Mouse Brain Lipid Metabolism" Proceedings 91, no. 1: 174. https://doi.org/10.3390/proceedings2023091174

APA Style

Rankovic, S., Nenadovic, A., Debeljak Martacic, J., Kovacevic, S., Milasin, J., Popovic, T., & Trbovich, A. (2023). Long-Term Sunflower Oil Diet Effects on Mouse Brain Lipid Metabolism. Proceedings, 91(1), 174. https://doi.org/10.3390/proceedings2023091174

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