Next Article in Journal
Self-Diagnostic Method for Resistive Displacement Sensors
Previous Article in Journal
Transparent PZT Capacitors on Glass for Actuating Applications
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Proceedings
Volume 91
Issue 1
10.3390/proceedings2023091421
proceedings-logo
Submit to this Journal
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

Development of a Method to Measure a Biomarker Panel Reflecting Dietary Exposure †

by
Stefania Noerman
1,*,
Marina Armeni
1,2,
Giuseppe Di Pede
3,
Raul Gonzalez-Domínguez
4,
Otto Savolainen
2,5 and
Rikard Landberg
1
1
Food and Nutrition Science Division, Department of Life Sciences, Chalmers University of Technology, 41258 Gothenburg, Sweden
2
Chalmers Mass Spectrometry Infrastructure, Department of Life Sciences, Chalmers University of Technology, 41258 Gothenburg, Sweden
3
Department of Food and Drugs, University of Parma, 43121 Parma, Italy
4
Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Universidad de Cádiz, 11009 Cádiz, Spain
5
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210 Kuopio, Finland
*
Author to whom correspondence should be addressed.
†
Presented at the 14th European Nutrition Conference FENS 2023, Belgrade, Serbia, 14–17 November 2023.
Proceedings 2023, 91(1), 421; https://doi.org/10.3390/proceedings2023091421
Published: 8 April 2024
(This article belongs to the Proceedings of The 14th European Nutrition Conference FENS 2023)
Versions Notes

Abstract

:
Assessment of dietary intake remains a large challenge in nutrition studies. The application of food intake biomarkers is a promising approach to complement widely used self-reported intake assessments and to improve accuracy. The development of metabolomics has enabled the discovery of many potential food intake biomarkers, but their applications are still limited. We aim to develop a semi-quantitative LC-MS/MS procedure to analyze a panel of plasma metabolites reflecting dietary exposure in a wide context. Our approach relies on a multi-analyte targeted LC-MS/MS method using a LC-QTRAP and commercially available reference compounds. A panel of 347 metabolites was selected, representing dietary intake (fruits and vegetables, coffee, tea, heat-treated food, wholegrain cereals, berries, cruciferous vegetables, and seafood) and key metabolites in the endogenous metabolism (fatty acids, amino acids, cholesterol metabolism, Krebs cycle, bile acids, and microbial metabolism) which are affected by specific diets, as well as lifestyle exposures, such as smoking and alcohol consumption. The application of this panel will help in assessing dietary exposures and their relationships to health outcomes. We will present the status of the work.

Author Contributions

Conceptualization, R.L. and O.S.; methodology, M.A. and R.G.-D.; software, S.N.; validation, M.A.; formal analysis, G.D.P. and M.A.; data curation, S.N.; writing—original draft preparation, S.N.; writing—review and editing, M.A., O.S. and R.L.; funding acquisition, R.G.-D. and R.L. All authors have read and agreed to the published version of the manuscript.

Funding

S.N. received funding from Formas (Dnr: 2019-02201) under the umbrella of the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL) and of the ERA-NET Cofund HDHL INTIMIC (GA N° 727565 of the EU Horizon 2020 Research and Innovation Programme). R.G.-D. is recipient of a “Miguel Servet” fellowship (CP21/00120) funded by “Instituto de Salud Carlos III”. R.L. is funded by the Swedish Research Council (no 2019-12064).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data sharing is not applicable to this abstract.

Conflicts of Interest

The authors declare no conflict of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Noerman, S.; Armeni, M.; Di Pede, G.; Gonzalez-Domínguez, R.; Savolainen, O.; Landberg, R. Development of a Method to Measure a Biomarker Panel Reflecting Dietary Exposure. Proceedings 2023, 91, 421. https://doi.org/10.3390/proceedings2023091421

AMA Style

Noerman S, Armeni M, Di Pede G, Gonzalez-Domínguez R, Savolainen O, Landberg R. Development of a Method to Measure a Biomarker Panel Reflecting Dietary Exposure. Proceedings. 2023; 91(1):421. https://doi.org/10.3390/proceedings2023091421

Chicago/Turabian Style

Noerman, Stefania, Marina Armeni, Giuseppe Di Pede, Raul Gonzalez-Domínguez, Otto Savolainen, and Rikard Landberg. 2023. "Development of a Method to Measure a Biomarker Panel Reflecting Dietary Exposure" Proceedings 91, no. 1: 421. https://doi.org/10.3390/proceedings2023091421

APA Style

Noerman, S., Armeni, M., Di Pede, G., Gonzalez-Domínguez, R., Savolainen, O., & Landberg, R. (2023). Development of a Method to Measure a Biomarker Panel Reflecting Dietary Exposure. Proceedings, 91(1), 421. https://doi.org/10.3390/proceedings2023091421

Article Metrics

Back to TopTop