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Animals
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Hematology and Transfusion Medicine in Animals
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Hematology and Transfusion Medicine in Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 26137

Special Issue Editors

Dr. Arianna Miglio

E-Mail Website
Guest Editor
School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy
Interests: clinical pathology; hematology; onco-hematology; transfusion medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandra Gavazza

E-Mail Website
Guest Editor
School of Biosciences and Veterinary Medicine, University of Camerino, Matelica (MC), Italy
Interests: clinical pathology; hematology; transfusion medicine; immunology
Dr. Maria Teresa Antognoni

E-Mail Website
Guest Editor
Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
Interests: clinical pathology; hematology; onco-hematology; transfusion medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The theme of this Special Issue of Animals is “Hematology and Transfusion Medicine in Animals”.

The study of veterinary transfusion medicine has undergone substantial changes in recent years in every aspect. Both the methods of sampling and transfusion of whole blood and blood products have been studied in depth. Furthermore, the methods of preservation of whole blood and blood product such as erythrocyte and plasma concentrates have been studied in order to increase the safety of this practice. Each step, i.e., donors and blood collection, screening, preparation, storage, and transfusion, has been considered and the improvements are beneficial to transfusion medicine in animals. These topics have been studied and described for dogs, cats, and horses, but little is known about this for with regard to other species, especially relatively exotic species.

Another interesting aspect of transfusion medicine is the epidemiology of blood transfusion in all countries and the identification of new blood group antigens in different animal species.

This topic cannot be separated from the knowledge of hematology in all animals, as well as information about the characteristics of the three blood populations (RBC, WBC, and PLT) and clotting factors. Alterations related to erythrocytes, leukocytes, and platelets (i.e., anemia, thrombocytopenia, leukemia, lymphoma, myelodysplasia, congenital and acquired coagulopathy) can provide important information relating to the most suitable products to transfuse in clinical cases.

Constant work by experts is important so that knowledge can be extended both in terms of early and accurate hematologic diagnoses and in terms of new transfusion therapies.

Prof. Maria Teresa Antognoni
Dr. Arianna Miglio
Dr. Alessandra Gavazza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hematology and onco-hematology
  • leukemia
  • lymphoma
  • transfusion medicine
  • blood
  • plasma
  • blood products
  • blood donors
  • blood groups
  • leukodepletion
  • all animal species
  • acquired and congenital coagulopathies

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Published Papers (7 papers)

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Research

16 pages, 1293 KiB  
Article
Establishment of Hematological and Plasma Biochemical Reference Values and Analysis of Risk Factors for Pet Sugar Gliders (Petaurus breviceps) in Taiwan
by Vivian C. Y. Lin, Ning-Ya Yang, Wen-Chi Lin, Jo-Wen Chen, Ching-Yi Yen and Yi-Lun Tsai
Animals 2022, 12(24), 3583; https://doi.org/10.3390/ani12243583 - 18 Dec 2022
Cited by 1 | Viewed by 4365
Abstract
Hematological and plasma biochemical examination are crucial in the veterinary care of sugar gliders, which are increasingly popular in Taiwan and the United States. However, published research of the species’ reference interval and related influencing factors were rare. The objectives of this study [...] Read more.
Hematological and plasma biochemical examination are crucial in the veterinary care of sugar gliders, which are increasingly popular in Taiwan and the United States. However, published research of the species’ reference interval and related influencing factors were rare. The objectives of this study were to establish the hematological and plasma biochemical reference values for captive sugar gliders in Taiwan and to evaluate the influence of factors including age, gender, neuter status, location, season, diet, caging arrangement, and other pets in the household. A total of 42 clinically healthy pet sugar gliders were recruited. Morphometrical measurements and physiological data were collected, and hematological and plasma biochemical examinations were performed. The reference value of each index was calculated using Reference Value Advisor (RVA) software, following the American Society for Veterinary Clinical Pathology (ASVCP) guidelines. Normality of data distribution was tested, and data transformation was conducted. The parametric method and robust method were used to determine reference limits. Univariate analysis was performed, and multiple regression models were built for each hematological and plasma biochemical parameter. Red blood cell, hematocrit, and hemoglobin levels were higher in males, compared to females, while they were lower in the neutered group, compared to the intact group. Relative neutrophil counts were higher in elder sugar gliders, while relative lymphocyte counts were lower. Aspartate transaminase levels were higher in elder sugar gliders, while albumin levels were lower. Blood urea nitrogen levels were highest in spring. The blood profile and related effects presented in this study can provide useful information for veterinary care in pet sugar gliders. Full article
(This article belongs to the Special Issue Hematology and Transfusion Medicine in Animals)
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10 pages, 14183 KiB  
Article
Hematology, Ultrastructure and Morphology of Blood Cells in Rufous-Winged Buzzards (Butastur liventer) from Thailand
by Pornchai Pornpanom, Chaiyan Kasorndorkbua, Preeda Lertwatcharasalakul and Chaleow Salakij
Animals 2022, 12(15), 1988; https://doi.org/10.3390/ani12151988 - 5 Aug 2022
Cited by 2 | Viewed by 2858
Abstract
In attempt to treat injured raptors and promote conservation awareness, the Kasetsart University Raptor Rehabilitation Unit (KURRU) was established in 2007. The complete blood counts (CBCs) are a manual tool used for the screening of raptor health. These tests require knowledge of blood [...] Read more.
In attempt to treat injured raptors and promote conservation awareness, the Kasetsart University Raptor Rehabilitation Unit (KURRU) was established in 2007. The complete blood counts (CBCs) are a manual tool used for the screening of raptor health. These tests require knowledge of blood cell morphology. This study aimed to describe the preliminary information of the hematology, ultrastructure, and morphology of blood cells in rufous-winged buzzards (RWB). There were 17 RWBs admitted into the KURRU. CBCs were manually performed by veterinary technicians. The morphology and morphometry of blood cells were observed from Wright-stained blood smears. Ultrastructure was observed from uranyl acetate and lead citrate-stained sections. The hematologic values were analyzed and described from individual RWBs that were clinically healthy, negative for blood parasites, and had PCV > 0.30 L/L. Consequently, CBCs of 12 out of 17 RWBs were included for descriptive hematologic values. Heterophils were the most prevalent white blood cells in RWBs. Of these 17 RWBs, 1 non-parasitized RWB showed hypochromic erythrocytes with PCV 0.18 L/L, which indicated that anemia in RWBs resulted from non-parasitic causes. The morphology of blood cells in RWBs was similar to those in other diurnal raptors, except that the lymphocytes showed pale or colorless cytoplasm. The electron micrographs highlighted that the basophil contained two types of granules: homogeneous electron-dense granules and reticulated electron-dense granules. The photomicrographs in this report are the scientific reference for identification of blood cells in RWBs. The CBCs from non-parasitized RWBs (clinically healthy) can be used as a cage mate reference in the KURRU. Additionally, we found evidence that evaluations of blood smears together with CBC examination were important in raptors. Full article
(This article belongs to the Special Issue Hematology and Transfusion Medicine in Animals)
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8 pages, 232 KiB  
Article
Hematological Parameters from the Feline Blood Donor to the Blood Unit: What Changes Are to Be Expected?
by Marta Vascellari, Antonio Carminato, Giovanni De Zottis, Matilde Bisconti, Laura Gagliazzo, Elisa Bozzato, Valentina Bertazzo and Annalisa Stefani
Animals 2022, 12(14), 1819; https://doi.org/10.3390/ani12141819 - 16 Jul 2022
Viewed by 1646
Abstract
Feline blood donation requires sedation to allow for good blood collection, avoiding venous damage and unnecessary donor stress. In the present study, we describe the variation of hematological parameters in a population of 74 healthy blood-donor cats that underwent the same sedation protocol, [...] Read more.
Feline blood donation requires sedation to allow for good blood collection, avoiding venous damage and unnecessary donor stress. In the present study, we describe the variation of hematological parameters in a population of 74 healthy blood-donor cats that underwent the same sedation protocol, including medetomidine, alfaxalone, and butorphanol. Changes in hematological parameters were evaluated in blood samples collected from conscious cats (group A), sedated cats (group B), and feline whole-blood units (FBUs) (group C). Significant differences were observed between unsedated and sedated cats: the mean RBC count, HGB, HCT, and RDW were significantly lower in sedated cats than in conscious ones, with a difference of 17.95%, 18.42%, 28.21%, and 10.00%, respectively. In accordance with previously reported data, our results confirm that sedation is a critical procedure in cats that can affect most of the hematological parameters. The second finding of our study is that no significant differences for the main hematological parameters were observed between sedated cats and FBUs, thus suggesting that the dilution with the conservative–anticoagulant solution exert negligible effects on these parameters with respect to samples of sedated animals. This hematological change must be taken into consideration since such parameters are important to define the quality of FBUs. Full article
(This article belongs to the Special Issue Hematology and Transfusion Medicine in Animals)
13 pages, 908 KiB  
Article
The Physical Activity-Dependent Hematological and Biochemical Changes in School Horses in Comparison to Blood Profiles in Endurance and Race Horses
by Małgorzata Maśko, Małgorzata Domino, Tomasz Jasiński and Olga Witkowska-Piłaszewicz
Animals 2021, 11(4), 1128; https://doi.org/10.3390/ani11041128 - 14 Apr 2021
Cited by 17 | Viewed by 3594
Abstract
Blood testing is one of the most important ways to improve performance, facilitate recovery and monitor the training of endurance and race horses. However, little is known about the physical activity-dependent changes of blood parameters in horses used for pleasure and in riding [...] Read more.
Blood testing is one of the most important ways to improve performance, facilitate recovery and monitor the training of endurance and race horses. However, little is known about the physical activity-dependent changes of blood parameters in horses used for pleasure and in riding schools. This study aimed to perform routine blood tests for training monitoring of sport horses in three different horse types of use. Then the values of blood indicators were compared between school, endurance and race horses to find similarities in the physical activity-dependent profile. The study was carried out on 15 endurance, 15 race and 15 school healthy horses who underwent the typical effort for their disciplines. The hemogram parameters, creatine phosphokinase (CPK), aspartate aminotransferase (AST), blood lactate (LAC), and total serum protein (TSP) concentrations were measured using the same protocol and equipment. Measurements of main hematological and biochemical physical activity-dependent parameters were conducted before, immediately after and 30 min after training. In school horses, the physical activity-dependent increase of WBC (40.9%) and CPK (76.4%) was similar to endurance horses, whereas an increase of RBC (19.1%), HGB (18.6%) and HCT (19.4%) were more similar to race horses. The moderate effort-dependent increase of LAC concentration (2775%) was lower than in race horses (7526%) and higher than in endurance horses (390%). Limiting the training or work monitoring assessment of school horses to only the endurance or racing blood profile may result in the omission of significant changes in hematological and biochemical parameters. Full article
(This article belongs to the Special Issue Hematology and Transfusion Medicine in Animals)
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14 pages, 540 KiB  
Article
Red Cell Distribution Width Has a Negative Prognostic Role in Dogs with Myxomatous Mitral Valve Disease
by Carlo Guglielmini, Chiara Martina Valentini, Barbara Contiero, Carlotta Valente and Helen Poser
Animals 2021, 11(3), 778; https://doi.org/10.3390/ani11030778 - 11 Mar 2021
Cited by 12 | Viewed by 2476
Abstract
Red cell distribution width (RDW) is a quantitative measurement of anisocytosis. This hematological parameter is an important prognostic biomarker for different cardiovascular disorders in humans but its influence on survival has been poorly investigated in dogs with cardiovascular disease. The RDW and various [...] Read more.
Red cell distribution width (RDW) is a quantitative measurement of anisocytosis. This hematological parameter is an important prognostic biomarker for different cardiovascular disorders in humans but its influence on survival has been poorly investigated in dogs with cardiovascular disease. The RDW and various clinical, complete blood count, serum biochemical and echocardiographic variables were retrospectively investigated in 146 client-owned dogs with myxomatous mitral valve disease (MMVD) at various disease stages, with or without concurrent diseases and treatment. Laboratory variables, including RDW, urea, and white blood cell (WBC), in addition to the echocardiographic variable left atrium to aorta ratio were found to be independent predictors of all-cause mortality at six months in a multivariable Cox proportional hazards regression model. In particular, the hazard ratio of RDW was 1.203 (95% confidence interval = 1.045–1.384; p = 0.010). The negative effect of increased RDW on outcome was confirmed using Kaplan–Meier curve analysis. The results of this study indicate that RDW acted as an independent predictor of negative outcome in dogs with MMVD. Full article
(This article belongs to the Special Issue Hematology and Transfusion Medicine in Animals)
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18 pages, 3635 KiB  
Article
Effects of Autologous Platelet-Rich Fibrin in Post-Extraction Alveolar Sockets: A Randomized, Controlled Split-Mouth Trial in Dogs with Spontaneous Periodontal Disease
by Adolfo Maria Tambella, Francesca Bartocetti, Giacomo Rossi, Livio Galosi, Giuseppe Catone, Annastella Falcone and Cecilia Vullo
Animals 2020, 10(8), 1343; https://doi.org/10.3390/ani10081343 - 4 Aug 2020
Cited by 10 | Viewed by 3992
Abstract
Periodontal disease (PD) is a common inflammatory condition in dogs; in severe stages, dental extraction is frequently required. Platelet-rich fibrin (PRF) has been used in human oral surgical procedures and has been experimentally tested on post-extraction sockets in healthy dogs. This is the [...] Read more.
Periodontal disease (PD) is a common inflammatory condition in dogs; in severe stages, dental extraction is frequently required. Platelet-rich fibrin (PRF) has been used in human oral surgical procedures and has been experimentally tested on post-extraction sockets in healthy dogs. This is the first split-mouth, randomized, controlled trial designed to compare post-extractive alveolar socket healing with and without topical application of PRF in canine spontaneous PD. Clinical evaluation, radiographic density, and histological scores for inflammation and regeneration were assessed at recruitment (T0) and after a three-week follow up (T1) on 12 dogs, for a total of 31 pairs of sockets. No complications or clinically evident differences between the treated sites and the control sites were observed. Comparing the radiographic densities of the extraction sites measured at T0 and T1, a significant enhancement was observed within the PRF group, but not within control group. The histological score decreased significantly from T0 to T1 within group PRF, but not within the control group; at T1, the PRF group showed a significantly lower histological score than the control group. These findings suggest that PRF could be able to stimulate the natural process of tissue healing and regeneration of post-extraction sites in dogs with spontaneous periodontal disease (PD). Full article
(This article belongs to the Special Issue Hematology and Transfusion Medicine in Animals)
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19 pages, 1838 KiB  
Article
Hematological and Biochemical Reference Intervals for 5 Adult Hunting Dog Breeds Using a Blood Donor Database
by Arianna Miglio, Alessandra Gavazza, Donatella Siepi, Francesco Bagaglia, Ambra Misia and Maria Teresa Antognoni
Animals 2020, 10(7), 1212; https://doi.org/10.3390/ani10071212 - 16 Jul 2020
Cited by 20 | Viewed by 4159
Abstract
Numerous studies have shown the importance of breed-related differences between hematological and biochemical results in veterinary medicine. The aim of this study is to determine hematologic and biochemical Reference Intervals (RIs) for 5 hunting dog breeds from a blood donor database, adopting an [...] Read more.
Numerous studies have shown the importance of breed-related differences between hematological and biochemical results in veterinary medicine. The aim of this study is to determine hematologic and biochemical Reference Intervals (RIs) for 5 hunting dog breeds from a blood donor database, adopting an indirect sampling method, and to compare them with laboratory established and published RIs to identify possible breed and attitude-related differences. The study analyzed the blood parameters of 445 adults (222 females and 223 male, with age ranging from 2 to 8 years, mean age 5.3 years), client-owned, clinically healthy blood donor dogs of 5 breeds: 156 Ariégeois, 52 Bleu de Gascogne, 64 Bracco italiano, 123 Segugio italiano, and 50 Briquet Griffon Vandeen. Statistical analysis was performed as recommended by the American Society of Veterinary Clinical Pathology (ASVCP) guidelines. RIs for red blood cells (RBC), hematocrit (HCT), hemoglobin (HB), main corpuscular volume (MCV), main corpuscular hemoglobin (MCH), main corpuscular hemoglobin concentration (MCHC), red distribution widht (RDW), white blood cells (WBC), and differential leukocytes count, PLT, Albumin, Total Protein, Urea, Creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) for each of the 5 breeds were performed, and significant differences with the established RIs were detected. We found significant differences in 12 hematologic and serum biochemical analytes for which a breed-specific variation appears to be the most plausible explanation. New RIs for HCT, MCH, MCHC, RDW, PLT, Monocytes, Eosinophils, Albumin, Urea, Creatinine, AST, and ALT are provided for at least 1 breed. Breed-specific RIs for adult hunting dogs will help avoid misinterpretation of laboratory results in these breeds. Full article
(This article belongs to the Special Issue Hematology and Transfusion Medicine in Animals)
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