Animal Models in Biomedical Research

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: closed (30 December 2021) | Viewed by 6163

Special Issue Editor


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Guest Editor
Central Animal Laboratory, Faculty of Medicine, University of Turku, FI-20014 Turku, Finland
Interests: Laboratory animal science; experimental disease models; prostate inflammation and cancer; GLP; toxicology; animal welfare
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Special Issue Information

Dear Colleagues,

Spontaneous and induced animal models have significantly contributed to scientific developments and the improvement of human and animal health.

Scientists usually utilize one or more of the scientific methods including in vitro, in silico, as well as vertebrate and non-vertebrate in vivo models. Veterinary clinical patients have increasingly been used as models of disease treatment.

However, the concern about the reproducibility and translatability of animal models has been increasingly addressed both in the scientific community and societally. The reproducibility and bench-to-bedside translatability of preclinical research relies on understanding the relevance and limitations and continuous efforts to improve the animal models.

This Special Issue welcomes original research articles and review articles dealing with emerging factors affecting the reproducibility and translatability of animal models, such as the standardization and design of animal experiments, interpretation of experimental data, genetic drift, environmental factors, gut microbiota, animal handling techniques, and hygienic conditions of animal facilities. Topics can also include the development and validation of alternative models for animals, the use of animals as disease models, and animal welfare.

Dr. Emrah Yatkin
Guest Editor

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Keywords

  • animal models
  • animal welfare and the 3Rs
  • alternative models
  • animal disease models
  • laboratory animals
  • model validation
  • reproducibility

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Published Papers (1 paper)

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Review

15 pages, 3243 KiB  
Review
Quality of Reporting in Preclinical Urethral Tissue Engineering Studies: A Systematic Review to Assess Adherence to the ARRIVE Guidelines
by Tariq O. Abbas, Abubakr Elawad, Abdul Kareem Pullattayil S. and Cristian Pablo Pennisi
Animals 2021, 11(8), 2456; https://doi.org/10.3390/ani11082456 - 21 Aug 2021
Cited by 6 | Viewed by 3953
Abstract
Preclinical research within the area of urethral tissue engineering has not yet been successfully translated into an efficient therapeutic option for patients. This gap could be attributed, in part, to inadequate design and reporting of the studies employing laboratory animals. In this study, [...] Read more.
Preclinical research within the area of urethral tissue engineering has not yet been successfully translated into an efficient therapeutic option for patients. This gap could be attributed, in part, to inadequate design and reporting of the studies employing laboratory animals. In this study, a systematic review was conducted to investigate the quality of reporting in preclinical studies utilizing tissue engineering approaches for urethral repair. The scope was on studies performed in rabbits, published between January 2014 and March 2020. Quality assessment of the data was conducted according to the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines by the scoring of a 38-item checklist in different categories. A total of 28 articles that fulfilled the eligibility criteria were included in the study. The range of ARRIVE score was from 0 to 100, taking into consideration having reported the item in question or not. The mean checklist score was 53%. The items that attained the highest scores included the number of animals utilized, the size of control and experimental groups, and the definition of experimental outcomes. The least frequently reported items included the data regarding the experimental procedure, housing and husbandry, determination and justification of the number of animals, and reporting of adverse events. Surprisingly, full disclosure about ethical guidelines and animal protocol approval was missing in 54% of the studies. No paper stated the sample size estimation. Overall, our study found that a large number of studies display inadequate reporting of fundamental information and that the quality of reporting improved marginally over the study period. We encourage a comprehensive implementation of the ARRIVE guidelines in animal studies exploring tissue engineering for urethral repair, not only to facilitate effective translation of preclinical research findings into clinical therapies, but also to ensure compliance with ethical principles and to minimize unnecessary animal studies. Full article
(This article belongs to the Special Issue Animal Models in Biomedical Research)
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