Prevention and Antimicrobial Surveillance of Hospital-Associated Infections

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 325

Special Issue Editor


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Guest Editor
2nd Pediatric Department, AHEPA Thessaloniki University General Hospital, Aristotle University of Thessaloniki, Kiriakidi 1, 546 36 Thessaloniki, Greece
Interests: pediatrics; antimicrobials; antimicrobial resistance

Special Issue Information

Dear Colleagues,

Nosocomial infections are a worldwide emerging problem causing life-threatening conditions and financial impact on healthcare systems. Neonatal, pediatric and adult patients infected by antibiotic-resistant nosocomial pathogens are difficult to treat and are associated with increased morbidity and mortality rates. Intensive care units are the most vulnerable departments in medical settings and health-associated infections in these units are difficult to treat. Hand and environmental hygiene, antimicrobial stewardship, care coordination, surveillance of infection patterns, screening and cohorting patients and coordination between different health care professionals are essential strategies for nosocomial infection control and prevention. Laboratory, pharmacological, clinical and epidemiological studies are required and are more than welcome in order to improve the management of the complex and multifactorial problem of health-care associated infections.

Dr. Theodouli Stergiopoulou
Guest Editor

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Keywords

  • infection monitoring
  • surveillance program
  • antimicrobial surveillance
  • healthcare-associated infections

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Published Papers (1 paper)

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Research

8 pages, 1395 KiB  
Communication
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolated from Bloodstream Infections in South Korea
by Wook Jong Jeon, Yoo Jung Kim, Ju Hui Seo, Jung Sik Yoo and Dong Chan Moon
Antibiotics 2024, 13(12), 1124; https://doi.org/10.3390/antibiotics13121124 (registering DOI) - 23 Nov 2024
Abstract
Background/Objectives: Bloodstream infection by carbapenem-resistant Acinetobacter baumannii (CRAB) is a serious clinical problem worldwide. To study its clonal relationship and genetic features, we report the draft genome sequence of CRAB strains isolated from human blood in South Korea. Methods: Among A. baumannii strains [...] Read more.
Background/Objectives: Bloodstream infection by carbapenem-resistant Acinetobacter baumannii (CRAB) is a serious clinical problem worldwide. To study its clonal relationship and genetic features, we report the draft genome sequence of CRAB strains isolated from human blood in South Korea. Methods: Among A. baumannii strains isolated from patients at nine general hospitals in 2020, 12 CRAB strains of different genotypes were selected. Genomic DNA was sequenced using a combination of Illumina MiSeq and Oxford Nanopore MinION platforms. Antimicrobial susceptibility testing was performed using the disk diffusion method. Antimicrobial resistance and virulence genes were investigated in silico using the Center for Genomic Epidemiology server and the Virulence Factors Database. Results: The multilocus sequence types of isolates included ST191, ST195, ST357, ST369, ST451, ST469, ST491, ST784, ST862, ST1933, ST2929, and a novel type, ST3326. The predominant sequence type, ST191, demonstrated close genetic relationships with several isolates, including ST469, ST369, ST195, ST784, ST491, and ST3326, with ST3326 classified as a subgroup of ST191. We found 18 antimicrobial resistance genes and one quaternary ammonium compound resistance gene. All examined strains harbored blaOXA-23, which is associated with carbapenem resistance. While variations in antibiotic and disinfectant resistance genes were observed, all isolates exhibited similar virulence factors, with the exception of the biofilm and capsule production genes. Conclusions: This nationwide report of the draft genome sequence of patient-derived strains provides valuable insights into the genomic features associated with clonal relationships and antimicrobial resistance of CRAB in bloodstream infections. Full article
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