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Antibiotics
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Resistance and Tolerance of Helicobacter pylori
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Resistance and Tolerance of Helicobacter pylori

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5310

Special Issue Editors

Dr. Paweł Krzyżek

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Guest Editor
Department of Medical Microbiology, Wroclaw Medical University, 50-368 Wroclaw, Poland
Interests: Helicobacter pylori; biofilm; coccoid forms; morphology; outer membrane vesicles; antibiotic tolerance; antimicrobial/antibiofilm activity
Special Issues, Collections and Topics in MDPI journals
Dr. Rossella Grande

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Guest Editor
Department of Pharmacy, University “G. d'Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Interests: microbial biofilms; Helicobacter pylori; Lactobacillus reuteri; outer membrane vesicles; extracellular DNA; antimicrobial/antibiofilm activity; human microbiome; probiotics; prebiotics and symbiotics
Special Issues, Collections and Topics in MDPI journals
Dr. Valentina Puca

E-Mail Website
Guest Editor
Department of Pharmacy, University “G. d'Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Interests: natural antimicrobials; anti-biofilm strategies; bacterial pathogens; anti-microbial resistance; medical microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Resistance to antibiotics is a global phenomenon generating huge costs and therapeutic difficulties. Therefore, monitoring of microbial resistance is one of the most important tasks of modern medicine. As a result of this, in 2017 the World Health Organization created a list of priority pathogens within which Helicobacter pylori was mentioned. The inclusion of this bacterium on the above list was associated with its ability to persistently colonize the host and induce a broad range of gastric diseases (including cancers), but was also related to the easiness of this pathogen to acquire resistance genes and become difficult to be treated.

The assumption of this Special Issue is to highlight the postulates of the WHO and to draw the attention of both scientists and clinicians to the importance of understanding mechanisms of H. pylori resistance and tolerance as a key strategy aimed at maintaining a high degree of eradication of this pathogen. As part of the Special Issue, we encourage to submit original research papers, short communications, and reviews describing the molecular phenomena responsible for the development of H. pylori antibiotic resistance, as well as the participation of complex physiological processes (biofilm production, transformation into coccoid forms, and secretion of membrane vesicles) in the tolerance or resistance of H. pylori to antimicrobial substances.

Dr. Paweł Krzyżek
Dr. Rossella Grande
Dr. Valentina Puca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Helicobacter pylori
  • antibiotic resistance
  • antibiotic tolerance
  • point mutations
  • efflux pumps
  • biofilm formation
  • coccoid forms
  • outer membrane vesicles

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Published Papers (2 papers)

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Research

12 pages, 1029 KiB  
Article
Antibiotic Resistance and Therapeutic Efficacy of Helicobacter pylori Infection in Pediatric Patients—A Tertiary Center Experience
by Felicia Galoș, Cătălin Boboc, Mara-Ioana Ieșanu, Mălina Anghel, Andreea Ioan, Elena Iana, Maria Teodora Coșoreanu and Anca Andreea Boboc
Antibiotics 2023, 12(1), 146; https://doi.org/10.3390/antibiotics12010146 - 11 Jan 2023
Cited by 7 | Viewed by 2126
Abstract
One of the most widespread bacterial infections worldwide, Helicobacter pylori is thought to affect almost half of the world’s population. Due to rising antibiotic resistance, treatment should be tailored according to antibiotic susceptibility testing (AST). This study aims to evaluate Helicobacter pylori antibiotic [...] Read more.
One of the most widespread bacterial infections worldwide, Helicobacter pylori is thought to affect almost half of the world’s population. Due to rising antibiotic resistance, treatment should be tailored according to antibiotic susceptibility testing (AST). This study aims to evaluate Helicobacter pylori antibiotic resistance and its therapeutic efficacy in children. We conducted a prospective, single-center study, that evaluated 68 children referred for upper gastrointestinal endoscopy (UGE) following chronic dyspeptic syndrome. Each patient underwent multiple biopsies to perform bacterial cultures with AST and histopathological examinations for the diagnosis. Patients without antibiotic resistance or negative cultures received a 10-day sequential therapy, while the others had the antibiotic regimen tailored based on AST. Fifty-nine patients with a positive biopsy-based diagnosis (24 males) were finally included. Bacterial cultures with AST were positive for 13 patients (22.03%) and the antibiotic resistance for clarithromycin was 15.38%. Fifty-seven patients were administered sequential therapy with an eradication rate of 94.73%. Clarithromycin-resistant patients were successfully treated with 10-day triple therapy of esomeprazole, amoxicillin, and metronidazole. Although bacterial cultures had a low positivity rate, sequential therapy had a successful eradication rate. Further studies are necessary to better assess Helicobacter pylori antibiotic resistance to provide tailored treatment and identify children that need closer monitoring. Full article
(This article belongs to the Special Issue Resistance and Tolerance of Helicobacter pylori)
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11 pages, 434 KiB  
Article
Multidrug-Resistant Helicobacter pylori Strains: A Five-Year Surveillance Study and Its Genome Characteristics
by Asif Sukri, Alfizah Hanafiah, Hamidah Yusoff, Nur Atiqah Shamsul Nizam, Zarith Nameyrra, Zhiqin Wong and Raja Affendi Raja Ali
Antibiotics 2022, 11(10), 1391; https://doi.org/10.3390/antibiotics11101391 - 11 Oct 2022
Cited by 9 | Viewed by 2581
Abstract
Background: The emergence of multidrug-resistant Helicobacter pylori has undermined eradication strategies to prevent the development of gastric cancer. This study was conducted to estimate the prevalence of secondary antibiotic resistance of H. pylori in urban multicultural areas in Malaysia. Methods: From January 2017 [...] Read more.
Background: The emergence of multidrug-resistant Helicobacter pylori has undermined eradication strategies to prevent the development of gastric cancer. This study was conducted to estimate the prevalence of secondary antibiotic resistance of H. pylori in urban multicultural areas in Malaysia. Methods: From January 2017 to December 2021, gastric biopsies from 218 patients with a history of H. pylori eradication failure were sent to our laboratory for antibiotic susceptibility testing. A minimal inhibitory concentration was determined for six antibiotics, namely metronidazole, clarithromycin, levofloxacin, amoxicillin, tetracycline, and rifampicin using the E-test method. Two multidrug-resistant H. pylori strains identified in this study were subjected to whole genome sequencing. Results: Eradication failure was observed to be significantly higher in the Malaysian Chinese patients than in the Malaysian Indian and Malay patients. H. pylori were successfully isolated from 51 patients (23.4%). Overall, the antibiotic resistance rates of H. pylori to metronidazole, clarithromycin, levofloxacin, and amoxicillin were 82.4% (42/51), 72.5% (37/51), 52.9% (27/51), and 3.9% (2/51), respectively. Resistance to tetracycline and rifampicin were not observed during the study period. Resistance to more than one antibiotic was observed in 82.4% (42/51) of the isolates, of which 42.2% (19/42) were resistant to three antibiotic classes. Resistance to both clarithromycin and metronidazole were most frequently observed in isolates with dual resistance (56.5%; 13/23). Codon substitutions in penicillin-binding protein 1A (V346L, V374L, G595_V596InsG, Y604H, and N608S) were detected in amoxicillin-resistance H. pylori strains. Herein, we report amoxicillin resistance in H. pylori isolated from Malaysian patients, and its resistance mechanism, for the first time. Conclusion: Our results show the increase trend in secondary multidrug resistance in H. pylori isolates, which warrants continuous surveillance. Full article
(This article belongs to the Special Issue Resistance and Tolerance of Helicobacter pylori)
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