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Antibiotics
Special Issues
Novel Fungal Metabolites with Antimicrobial Activities
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Novel Fungal Metabolites with Antimicrobial Activities

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Fungi and Their Metabolites".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 6938

Special Issue Editor

Prof. Dr. Gary A. Strobel

E-Mail Website
Guest Editor
Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA
Interests: endophytic fungi; secondary products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi, as eukaryotic organisms, make a plethora of metabolites. One of the most eye catching compounds was the discovery of penicillin which changed the way humans have coped with many infectious diseases over the past 80 years. On the other hand, fungi also make compounds that are found in foods and feeds that are toxic. Also, many plant pathogens utilize toxins to be further the course of disease progression. Basically, this issue is devoted to all aspects of fungal metabolites from their discovery and their structural elucidation, to their utility and the genetic processes controlling their production. Likewise, the editors are interested in receiving papers that provide novelty and original insights and discoveries related to all aspects of fungal metabolites. If your paper is well prepared and approved for publication, you may be eligible for discounts for your publication.

Prof. Dr. Gary A. Strobel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (2 papers)

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Research

9 pages, 571 KiB  
Article
Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035
by Fuhang Song, Rui Lin, Na Yang, Jia Jia, Shangzhu Wei, Jiahui Han, Jiangpeng Li, Hongkai Bi and Xiuli Xu
Antibiotics 2021, 10(4), 377; https://doi.org/10.3390/antibiotics10040377 - 3 Apr 2021
Cited by 14 | Viewed by 3156
Abstract
Four new secondary metabolites, including one spiro[anthracenone-xanthene] derivative aspergiloxathene A (1), one penicillide analogue, Δ2′-1′-dehydropenicillide (2), and two new phthalide derivatives, 5-methyl-3-methoxyepicoccone (3) and 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (4), together with four known compounds, yicathin [...] Read more.
Four new secondary metabolites, including one spiro[anthracenone-xanthene] derivative aspergiloxathene A (1), one penicillide analogue, Δ2′-1′-dehydropenicillide (2), and two new phthalide derivatives, 5-methyl-3-methoxyepicoccone (3) and 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (4), together with four known compounds, yicathin C (5), dehydropenicillide (6), 3-methoxyepicoccone (7), 4-hydroxy-6-methoxy-5-methylphthalide (8), were identified from the marine-derived fungus Aspergillus sp. IMCASMF180035. Their structures were determined by spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance (NMR) techniques. Compound 1 was identified as the first jointed molecule by xanthene and anthracenone moieties possessing an unprecedented carbon skeleton with spiro-ring system. All compounds were evaluated activities against Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Escherichia coli, Escherichia faecium, Pseudomonas aeruginosa, and Helicobacter pylori. Compound 1 showed significant inhibitory effects against S. aureus and MRSA, with minimum inhibitory concentration (MIC) values of 5.60 and 22.40 µM. Compounds 2 and 6 exhibited potent antibacterial activities against H. pylori, with MIC values of 21.73 and 21.61 µM, respectively. Full article
(This article belongs to the Special Issue Novel Fungal Metabolites with Antimicrobial Activities)
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10 pages, 1779 KiB  
Article
Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8
by Xiao-Shan Shi, Yin-Ping Song, Ling-Hong Meng, Sui-Qun Yang, Dun-Jia Wang, Xing-Wang Zhou, Nai-Yun Ji, Bin-Gui Wang and Xiao-Ming Li
Antibiotics 2021, 10(2), 213; https://doi.org/10.3390/antibiotics10020213 - 20 Feb 2021
Cited by 14 | Viewed by 2713
Abstract
Carotane sesquiterpenes are commonly found in plants but are infrequently reported in the fungal kingdom. Chemical investigation of Trichoderma virens QA-8, an endophytic fungus associated with the inner root tissue of the grown medicinal herb Artemisia argyi H. Lév. and Vaniot, resulted in [...] Read more.
Carotane sesquiterpenes are commonly found in plants but are infrequently reported in the fungal kingdom. Chemical investigation of Trichoderma virens QA-8, an endophytic fungus associated with the inner root tissue of the grown medicinal herb Artemisia argyi H. Lév. and Vaniot, resulted in the isolation and characterization of five new carotane sesquiterpenes trichocarotins I–M (1–5), which have diverse substitution patterns, and seven known related analogues (6–12). The structures of these compounds were established on the basis of a detailed interpretation of their NMR and mass spectroscopic data, and the structures including the relative and absolute configurations of compounds 1–3, 5, 9, and 10 were confirmed by X-ray crystallographic analysis. In the antibacterial assays, all isolates exhibited potent activity against Escherichia coli EMBLC-1, with MIC values ranging from 0.5 to 32 µg/mL, while 7β-hydroxy CAF-603 (7) strongly inhibited Micrococcus luteus QDIO-3 (MIC = 0.5 µg/mL). Structure-activity relationships of these compounds were discussed. The results from this study demonstrate that the endophytic fungus T. virens QA-8 from the planted medicinal herb A. argyi is a rich source of antibacterial carotane sesquiterpenes, and some of them might be interesting for further study to be developed as novel antibacterial agents. Full article
(This article belongs to the Special Issue Novel Fungal Metabolites with Antimicrobial Activities)
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