Oxidative Stress and Sperm: Technical, Biological and Clinical Aspects—2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 April 2025
Special Issue Editor
Interests: male infertility; sperm biology; oxidative stress; sperm DNA fragmentation; semen analysis; flow cytometry; nutrition; environmental pollution
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress appears to be an underlying cause for many cases of male infertility, as it could be the converging step for several environmental, biological and lifestyle factors impacting sperm formation and function. Induction of reactive oxygen species production is detrimental during in vitro sperm manipulation, including selection for oocyte insemination and semen cryopreservation, posing a potential risk to couples treated with assisted reproductive techniques. Oxidative stress is one of the main mechanisms responsible for sperm DNA damage, including DNA fragmentation, a genome anomaly negatively affecting both natural and assisted reproduction. In addition, emerging data suggest that oxidative stress could alter the sperm epigenome. Both genetic and epigenetic damage has the potential to impact not only male reproductive function but also embryo development and the health of offspring.
In this context, further research in this field appears to be of the upmost importance. However, despite a huge number of published studies, there are many areas that remain little explored, including, but not limited to, the following: reliable techniques for revealing oxidative stress; the biological mechanisms of inducing genetic and epigenetic sperm damages; and the clinical meaning and use of the knowledge in this field. The poor clinical results obtained up to now for in vitro and/or in vitro treatment with antioxidant compounds further underline the need for deeper knowledge on this topic.
Dr. Monica Muratori
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- male infertility
- ROS
- oxidative sperm DNA damage
- sperm DNA fragmentation
- sperm epigenetic damage
- assisted reproductive techniques
- in vitro sperm manipulation
- antioxidants
- embryo development
- pregnancy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
