Therapeutic Potential of Bioactive Substances in Oxidative Stress-Induced Carcinogenesis
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".
Deadline for manuscript submissions: 15 May 2025 | Viewed by 225
Special Issue Editor
Interests: genotoxicological assessment and safety; experimental models of carcinogenesis; cancer chemoprevention by phytocompounds; mechanisms of oxidative stress induction and the main antioxidant systems; molecular mechanisms involved in the antitumor activity of natural and synthetic compounds; food and health
Special Issue Information
Dear Colleagues,
There is already a consensus that oxidative stress (OS) is not only a result of carcinogenesis but also a significant contributor to its development and progression. The main mechanisms by which OS contributes to carcinogenesis are related to the induction of gene mutations that activate the cell signaling pathways, stimulating cell division and inhibiting apoptosis, promoting angiogenesis, and favoring immune evasion, thereby facilitating the survival and dissemination of tumor cells.
Bioactive substances found in foods and medicinal plants have attracted interest due to their therapeutic potential in cancer prevention and treatment. Studies have demonstrated that antioxidants, such as polyphenols, carotenoids, and vitamins, found in fruits, vegetables, and teas possess protective properties against OS and carcinogenesis. Moreover, bioactive substances in combination with conventional therapies have shown potential effects, increasing treatment efficacy and reducing side effects. Therefore, prospecting substances with therapeutic potential and elucidating their mechanisms of action in the carcinogenesis process may lead to the development of more effective and safer therapeutic strategies.
We invite researchers to propose reviews or original research articles on the latest advances in the study of the therapeutic potential of bioactive substances in OS-induced carcinogenesis that may be included in the following potential topics (but are not limited to them):
- Antioxidant bioactive substances in cancer chemoprevention;
- Antioxidant bioactive substances in cancer chemotherapy;
- Antimutagenic bioactive substances with antioxidant potential;
- Mechanisms of action of bioactive agents in different stages of carcinogenesis;
- Bioactive substances and conventional therapies.
Prof. Dr. Pollyanna Francielli De Oliveira
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- carcinogenesis
- reactive oxygen species
- free radicals
- oxidative stress
- therapeutics
- bioactive substances
- antioxidants
- dietary supplementation
- chemoprevention
- biomarkers
- DNA damage
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
