NADPH Oxidase–Mediated ROS in Pulmonary Arterial Hypertension
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: closed (31 January 2019) | Viewed by 10367
Special Issue Editor
Interests: reactive oxygen species (ROS); NADPH oxidase; Galectin-3; PAH; vascular remodeling; redox signaling; adventitia; inflammation; vascular biology
Special Issue Information
Dear Colleagues,
Pulmonary arterial hypertension (PAH) is a progressive disease that involves the loss of endothelial function together with aberrant smooth muscle cell growth, inflammation, and fibrosis that involves multiple cell types in the pulmonary arteries (PA). How PAH develops remains incompletely understood, but evidence for production of reactive oxygen species (ROS) in PA has been well documented. There are many different types of ROS with multiple sources that may contribute to the pulmonary arterial remodeling that is a hallmark of PAH. The NADPH oxidase (Nox) family is comprised of seven structurally related transmembrane NADPH-dependent oxidoreductases that include the Nox enzymes, as well as the Duoxes. Accumulating evidence strongly suggests that ROS derived from NADPH oxidase play an important role in pulmonary arterial remodeling. The signaling mechanisms leading to activation of the Nox enzymes are diverse, and more precise targeting of the major sources of ROS in specific cell types in PA will likely be more effective towards development of therapeutic treatments for PAH.
The goal of this Special Issue is to bring together and outline the current state and importance of the role of NADPH oxidases in the context of PAH. Suppressing pathophysiological levels of ROS by manipulating NOX enzymes, their regulators, and effector ROS targets appears to be attractive therapeutic strategies to treat PAH and other related pulmonary vascular diseases. This Special Issue invites original research and review articles on the subject of NADPH-oxidases in the context of pulmonary vascular pathophysiology and all the related topics indicated below:
Prof. Scott A. Barman
Guest Editor
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Keywords
- Reactive Oxygen Species
- Inflammation
- Pulmonary Arterial Hypertension
- Redox Signaling
- Endothelial Cell
- Pulmonary Arterial Remodeling
- Adventitia
- Fibrosis
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