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Antimicrobial Biofilm: Materials, Properties and Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 609

Special Issue Editor


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Guest Editor
Laboratory of Oral Microbiology Research, Microbiology and parasitology Department, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil
Interests: biofilms; antimicrobial resistance; natural products; nanotechnology; bacteriology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biofilms, structured communities of microorganisms embedded in a self-produced extracellular matrix, are notorious for their resistance to conventional antimicrobial treatments. The presence of biofilms in medical, industrial, and environmental settings poses significant challenges, leading to persistent infections, equipment fouling, and contamination. This proposed Special Issue on“Antimicrobial Biofilm: Materials, Properties and Applications” seeks to explore the latest advancements in the development of novel materials and strategies designed to inhibit, disrupt, or eradicate biofilms. Contributions are invited that span a wide range of topics, including the design and synthesis of antimicrobial materials, surface modifications, nanotechnology approaches, and the mechanistic understanding of biofilm resistance. Additionally, studies that focus on the application of these materials in healthcare, food processing, water treatment, and other relevant industries are highly encouraged. This issue aims to provide a comprehensive platform for the discussion of emerging trends and innovative solutions in the battle against biofilm-associated problems.

Prof. Dr. Roberto Christ Vianna Santos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial materials
  • biofilm resistance
  • surface modification
  • nanotechnology
  • extracellular matrix
  • biofilm disruption
  • healthcare applications
  • industrial biofilm control
  • microbial communities
  • contamination prevention

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Published Papers (1 paper)

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Research

10 pages, 3820 KiB  
Article
Antimicrobial, Synergistic, and Antibiofilm Activity of Sildenafil Against Pseudomonas aeruginosa: Preliminary Studies
by Thais de Moraes Barin, Camilla Filippi dos Santos Alves, Cristiane Antunes Teixeira, Camila Marina Verdi, Kelly Schneider Moreira, Thiago Burgo, Vitória Fernanda Belmonte Novais, Rodrigo de Almeida Vaucher and Roberto Christ Vianna Santos
Appl. Sci. 2024, 14(22), 10089; https://doi.org/10.3390/app142210089 - 5 Nov 2024
Viewed by 443
Abstract
The present study tested sildenafil citrate as an example of pharmacological repositioning against the opportunistic pathogen Pseudomonas aeruginosa, known for its potent biofilm formation. We evaluated its antimicrobial, synergistic, and antibiofilm effects using broth microdilution, checkerboard assays, and atomic force microscopy techniques. [...] Read more.
The present study tested sildenafil citrate as an example of pharmacological repositioning against the opportunistic pathogen Pseudomonas aeruginosa, known for its potent biofilm formation. We evaluated its antimicrobial, synergistic, and antibiofilm effects using broth microdilution, checkerboard assays, and atomic force microscopy techniques. Sildenafil citrate showed antimicrobial activity, effectively inhibiting bacterial growth at minimum inhibitory concentrations ranging from 3.12 to 6.25 mg/mL and minimum bactericidal concentrations between 3.12 and 25 mg/mL. When combined with reference antimicrobial agents—cefepime, imipenem, cilastatin, and polymyxin—sildenafil citrate had a synergistic effect. It also effectively inhibited and eradicated biofilms, reducing total biomass by 87.1% for inhibition and 83.8% for eradication. Atomic force microscopy confirmed the efficacy of sildenafil citrate in destroying and inhibiting biofilms, decreasing the overall amplitude of the biofilm. Consequently, sildenafil citrate appears to be a promising candidate for combination with commercial antimicrobial drugs to prevent and treat P. aeruginosa infections. Full article
(This article belongs to the Special Issue Antimicrobial Biofilm: Materials, Properties and Applications)
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