Transition-Metal Contrast Agents for MRI
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 393
Related Special Issue: Transition-Metal Contrast Agents for MRI
Special Issue Editors
Interests: bioinorganic chemistry; bimodal imaging agents; MRI contrast agents based on transition metal complexes; ligand synthesis; structure selective interactions of compounds with DNA and RNA; magnetic properties of complexes and particles
Special Issues, Collections and Topics in MDPI journals
Interests: molecular imaging probes and therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
MRI contrast agents are routinely used in MRI examinations for diagnosis in the clinic and are essential to modern diagnostic techniques. By far, the majority of these agents are coordination complexes of Gd(III), which exhibit high magnetic susceptibility and impart contrast by enhancing the relaxation rate of surrounding water protons. However, growing safety concerns over the use of lanthanide-based contrast agents have led the drive to find alternatives to gadolinium-based MRI agents due to links with nephrogenic systemic fibrosis and reports of Gd(III) retention in the brains and bone of patients receiving multiple doses.
One approach is to look to endogenous transition metal ions as alternatives. Several strategies can be used to achieve contrast in proton MRI using transition metal ions, including conventional relaxivity agents, which exploit paramagnetic relaxation enhancement, and paraSHIFT agents, for which paramagnetic hyperfine shifts are induced by anisotropic magnetic susceptibility. Spin changes can be induced with an external stimulus using transition metal chemistry in pursuit of switchable contrast agents for imaging biochemical processes. This Special Issue of Applied Sciences aims to publish a collection of research contributions of recent work in the development, study, and understanding of transition metal contrast agents for MRI.
You may choose our Joint Special Issue in Magnetochemistry.
Prof. Dr. Janet R. Morrow
Dr. Nicola J. Rogers
Guest Editors
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Keywords
- magnetic resonance imaging
- contrast agents
- relaxivity
- paraSHIFT
- paraCEST
- transition metal ions
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