Submit to Applied Sciences Review for Applied Sciences Propose a Special Issue

Journal Menu

Journal Browser

Fluid Flows Modelling in Microfluidic Systems

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Benefits of Publishing in a Special Issue
Published Papers

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Mechanical Engineering".

Deadline for manuscript submissions: closed (10 February 2022) | Viewed by 30220

Share This Special Issue

Special Issue Editor

Dr. Mehdi Jangi

E-Mail Website
Guest Editor

Department of Mechanical Engineering, University of Birmingham, Edgbaston, Birmingham, UK
Interests: computational fluid dynamics; numerical tools for modelling multiphase flows; CFD modelling of turbulent reacting flows; modelling fluid flows in microfluidic systems; chemically reactive interfaces
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics enables unprecedented precision and control of critical processes such as mixing, pumping, sensing, chemical and biochemical reactions, etc., in microscales. This, in turn, provides unique advantages in handling fluidic processes, and can significantly reduce the complexity of the system and its operational costs. Despite great developments in this area, the underlying physical mechanisms are still not fully understood. This is partly because some of the key controlling processes occur in such scales that are not fully accessible, experimentally.

This special issue aims at addressing this issue by gathering and publishing the best practice and the state-of-the-art in Fluid Flows Modelling in Microfluidic Systems. The Fluid Flows Modelling in Microfluidic Systems is a place to publish both numerical and experimental studies in fluid systems associated with fluidic devices.

Suitable topics for this Special Issue are as follows, but are not limited to:

Mathematical models
Computational Fluid dynamics
Nonnewotinian fluids in fluidic devices
Two-phase flow in fluidic devices
Micro and nanobubble dynamics
Acustofluidics
Heat and mass transfer in microfluidic systems
Micro and nanodroplets dynamics
Breakup and coalescence in fluidics
Continuous microreactors
Discrete microreactors
Surface treatments
Interface dynamics and contact

Dr. Mehdi Jangi

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Mathematical models
Computational Fluid dynamics
Nonnewotinian fluids in fluidic devices
Two-phase flow in fluidic devices
Micro and nanobubble dynamics
Acustofluidics
Heat and mass transfer in microfluidic systems
Micro and nanodroplets dynamics
Breakup and coalescence in fluidics
Continuous microreactors
Discrete microreactors
Surface treatments
Interface dynamics and contact

Benefits of Publishing in a Special Issue

Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (9 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

28 pages, 11347 KiB

Open AccessFeature PaperArticle

The Influence of Electrolyte Flow Hydrodynamics on the Performance of a Microfluidic Dye-Sensitized Solar Cell

by Roman G. Szafran and Mikita Davykoza

Appl. Sci. 2021, 11(24), 12090; https://doi.org/10.3390/app112412090 - 18 Dec 2021

Cited by 3 | Viewed by 3017

Abstract

The dye-sensitized solar cells microfluidically integrated with a redox flow battery (µDSSC-RFB) belong to a new emerging class of green energy sources with an inherent opportunity for energy storage. The successful engineering of microfluidically linked systems is, however, a challenging subject, as the hydrodynamics of electrolyte flow influences the electron and species transport in the system in several ways. In the article, we have analyzed the microflows hydrodynamics by means of the lattice-Boltzmann method, using the algebraic solution of the Navier-Stokes equation for a duct flow and experimentally by the micro particle image velocimetry method. Several prototypes of µDSSC were prepared and tested under different flow conditions. The efficiency of serpentine µDSSC raised from 2.8% for stationary conditions to 3.1% for electrolyte flow above 20 mL/h, while the fill factor increased about 13% and open-circuit voltage from an initial 0.715 V to 0.745 V. Although the hexagonal or circular configurations are the straightforward extensions of standard photo chambers of solar cells, those configurations are hydrodynamically less predictable and unfavorable due to large velocity gradients. The serpentine channel configuration with silver fingers would allow for the scaling of the µDSSC-RFB systems to the industrial scale without loss of performance. Furthermore, the deterioration of cell performance over time can be inhibited by the periodic sensitizer regeneration, which is the inherent advantage of µDSSC. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Graphical abstract

13 pages, 4694 KiB

Open AccessFeature PaperArticle

The Lattice-Boltzmann Modeling of Microflows in a Cell Culture Microdevice for High-Throughput Drug Screening

by Roman G. Szafran and Mikita Davykoza

Appl. Sci. 2021, 11(19), 9140; https://doi.org/10.3390/app11199140 - 1 Oct 2021

Cited by 4 | Viewed by 2127

Abstract

The aim of our research was to develop a numerical model of microflows occurring in the culture chambers (CC) of a microfluidic device of our construction for high-throughput drug screening. The incompressible fluid flow model is based on the lattice-Boltzmann equation, with an external body force term approximated by the He-Shan-Doolen scheme and the Bhatnagar-Gross-Krook approximation of the collision operator. The model accuracy was validated by the algebraic solution of the Navier–Stokes equation (NSE) for a fully developed duct flow, as well as experimentally. The mean velocity prediction error for the middle-length cross-section of CC was 1.0%, comparing to the NSE algebraic solution. The mean error of volumetric flow rate prediction was 6.1%, comparing to the experimental results. The analysis of flow hydrodynamics showed that the discrepancies from the plug-flow-like velocity profile are observed close to the inlets only, and do not influence cell cultures in the working area of CC. Within its workspace area, the biochip provides stable and homogeneous fully developed laminar flow conditions, which make the procedures of gradient generation, cell seeding, and cell-staining repeatable and uniform across CC, and weakly dependent on perturbations. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Graphical abstract

12 pages, 10400 KiB

Open AccessArticle

Flow Control Techniques for Enhancing the Bio-Recognition Performance of Microfluidic-Integrated Biosensors

by Fatemeh Shahbazi, Mohammad Souri, Masoud Jabbari and Amir Keshmiri

Appl. Sci. 2021, 11(15), 7168; https://doi.org/10.3390/app11157168 - 3 Aug 2021

Cited by 4 | Viewed by 2405

Abstract

Biosensors are favored devices for the fast and cost-effective detection of biological species without the need for laboratories. Microfluidic integration with biosensors has advanced their capabilities in selectivity, sensitivity, controllability, and conducting multiple binding assays simultaneously. Despite all the improvements, their design and fabrication are still challenging and time-consuming. The current study aims to enhance microfluidic-integrated biosensors’ performance. Three different functional designs are presented with both active (with the help of electroosmotic flow) and passive (geometry optimization) methods. For validation and further studies, these solutions are applied to an experimental setup for DNA hybridization. The numerical results for the original case have been validated with the experimental data from previous literature. Convection, diffusion, migration, and hybridization of DNA strands during the hybridization process have been simulated with finite element method (FEM) in 3D. Based on the results, increasing the velocity on top of the functionalized surface, by reducing the thickness of the microchamber in that area, would increase the speed of surface coverage by up to 62%. An active flow control with the help of electric field would increase this speed by 32%. In addition, other essential parameters in the fabrication of the microchamber, such as changes in pressure and bulk concentration, have been studied. The suggested designs are simple, applicable and cost-effective, and would not add extra challenges to the fabrication process. Overall, the effect of the geometry of the microchamber on the time and effectiveness of biosensors is inevitable. More studies on the geometry optimization of the microchamber and position of the electrodes using machine learning methods would be beneficial in future works. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Figure 1

22 pages, 4473 KiB

Open AccessFeature PaperArticle

Design Optimization of Centrifugal Microfluidic “Lab-on-a-Disc” Systems towards Fluidic Larger-Scale Integration

by Jens Ducrée

Appl. Sci. 2021, 11(13), 5839; https://doi.org/10.3390/app11135839 - 23 Jun 2021

Cited by 9 | Viewed by 3037

Abstract

Enhancing the degree of functional multiplexing while assuring operational reliability and manufacturability at competitive costs are crucial ingredients for enabling comprehensive sample-to-answer automation, e.g., for use in common, decentralized “Point-of-Care” or “Point-of-Use” scenarios. This paper demonstrates a model-based “digital twin” approach, which efficiently supports the algorithmic design optimization of exemplary centrifugo-pneumatic (CP) dissolvable-film (DF) siphon valves toward larger-scale integration (LSI) of well-established “Lab-on-a-Disc” (LoaD) systems. Obviously, the spatial footprint of the valves and their upstream laboratory unit operations (LUOs) have to fit, at a given radial position prescribed by its occurrence in the assay protocol, into the locally accessible disc space. At the same time, the retention rate of a rotationally actuated CP-DF siphon valve and, most challengingly, its band width related to unavoidable tolerances of experimental input parameters need to slot into a defined interval of the practically allowed frequency envelope. To accomplish particular design goals, a set of parametrized metrics is defined, which are to be met within their practical boundaries while (numerically) minimizing the band width in the frequency domain. While each LSI scenario needs to be addressed individually on the basis of the digital twin, a suite of qualitative design rules and instructive showcases structures are presented. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Figure 1

16 pages, 3605 KiB

Open AccessFeature PaperArticle

Finger-Actuated Microneedle Array for Sampling Body Fluids

by Misagh Rezapour Sarabi, Abdollah Ahmadpour, Ali K. Yetisen and Savas Tasoglu

Appl. Sci. 2021, 11(12), 5329; https://doi.org/10.3390/app11125329 - 8 Jun 2021

Cited by 29 | Viewed by 5210

Abstract

The application of microneedles (MNs) for minimally invasive biological fluid sampling is rapidly emerging, offering a user-friendly approach with decreased insertion pain and less harm to the tissues compared to conventional needles. Here, a finger-powered microneedle array (MNA) integrated with a microfluidic chip was conceptualized to extract body fluid samples. Actuated by finger pressure, the microfluidic device enables an efficient approach for the user to collect their own body fluids in a simple and fast manner without the requirement for a healthcare worker. The processes for extracting human blood and interstitial fluid (ISF) from the body and the flow across the device, estimating the amount of the extracted fluid, were simulated. The design in this work can be utilized for the minimally invasive personalized medical equipment offering a simple usage procedure. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Figure 1

15 pages, 15893 KiB

Open AccessArticle

Pressure-Driven Nitrogen Flow in Divergent Microchannels with Isothermal Walls

by Amin Ebrahimi, Vahid Shahabi and Ehsan Roohi

Appl. Sci. 2021, 11(8), 3602; https://doi.org/10.3390/app11083602 - 16 Apr 2021

Cited by 20 | Viewed by 3782

Abstract

Gas flow and heat transfer in confined geometries at micro-and nanoscales differ considerably from those at macro-scales, mainly due to nonequilibrium effects such as velocity slip and temperature jump. Nonequilibrium effects increase with a decrease in the characteristic length-scale of the fluid flow or the gas density, leading to the failure of the standard Navier–Stokes–Fourier (NSF) equations in predicting thermal and fluid flow fields. The direct simulation Monte Carlo (DSMC) method is employed in the present work to investigate pressure-driven nitrogen flow in divergent microchannels with various divergence angles and isothermal walls. The thermal fields obtained from numerical simulations are analysed for different inlet-to-outlet pressure ratios (

1.5 \leq Π \leq 2.5

), tangential momentum accommodation coefficients, and Knudsen numbers (

0.05 \leq Kn \leq 12.5

), covering slip to free-molecular rarefaction regimes. The thermal field in the microchannel is predicted, heat-lines are visualised, and the physics of heat transfer in the microchannel is discussed. Due to the rarefaction effects, the direction of heat flow is largely opposite to that of the mass flow. However, the interplay between thermal and pressure gradients, which are affected by geometrical configurations of the microchannel and the applied boundary conditions, determines the net heat flow direction. Additionally, the occurrence of thermal separation and cold-to-hot heat transfer (also known as anti-Fourier heat transfer) in divergent microchannels is explained. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Figure 1

16 pages, 2639 KiB

Open AccessFeature PaperArticle

A Numerical Study of Sub-Millisecond Integrated Mix-and-Inject Microfluidic Devices for Sample Delivery at Synchrotron and XFELs

by Majid Hejazian, Eugeniu Balaur and Brian Abbey

Appl. Sci. 2021, 11(8), 3404; https://doi.org/10.3390/app11083404 - 10 Apr 2021

Cited by 9 | Viewed by 2592

Abstract

Microfluidic devices which integrate both rapid mixing and liquid jetting for sample delivery are an emerging solution for studying molecular dynamics via X-ray diffraction. Here we use finite element modelling to investigate the efficiency and time-resolution achievable using microfluidic mixers within the parameter range required for producing stable liquid jets. Three-dimensional simulations, validated by experimental data, are used to determine the velocity and concentration distribution within these devices. The results show that by adopting a serpentine geometry, it is possible to induce chaotic mixing, which effectively reduces the time required to achieve a homogeneous mixture for sample delivery. Further, we investigate the effect of flow rate and the mixer microchannel size on the mixing efficiency and minimum time required for complete mixing of the two solutions whilst maintaining a stable jet. In general, we find that the smaller the cross-sectional area of the mixer microchannel, the shorter the time needed to achieve homogeneous mixing for a given flow rate. The results of these simulations will form the basis for optimised designs enabling the study of molecular dynamics occurring on millisecond timescales using integrated mix-and-inject microfluidic devices. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Figure 1

13 pages, 835 KiB

Open AccessArticle

The Knudsen Paradox in Micro-Channel Poiseuille Flows with a Symmetric Particle

by Ananda Subramani Kannan, Tejas Sharma Bangalore Narahari, Yashas Bharadhwaj, Andreas Mark, Gaetano Sardina, Dario Maggiolo, Srdjan Sasic and Henrik Ström

Appl. Sci. 2021, 11(1), 351; https://doi.org/10.3390/app11010351 - 31 Dec 2020

Cited by 4 | Viewed by 3809

Abstract

The Knudsen paradox—the non-monotonous variation of mass-flow rate with the Knudsen number—is a unique and well-established signature of micro-channel rarefied flows. A particle which is not of insignificant size in relation to the duct geometry can significantly alter the flow behavior when introduced in such a system. In this work, we investigate the effects of a stationary particle on a micro-channel Poiseuille flow, from continuum to free-molecular conditions, using the direct simulation Monte-Carlo (DSMC) method. We establish a hydrodynamic basis for such an investigation by evaluating the flow around the particle and study the blockage effect on the Knudsen paradox. Our results show that with the presence of a particle this paradoxical behavior is altered. The effect is more significant as the particle becomes large and results from a shift towards relatively more ballistic molecular motion at shorter geometrical distances. The need to account for combinations of local and non-local transport effects in modeling reactive gas–solid flows in confined geometries at the nano-scale and in nanofabrication of model pore systems is discussed in relation to these results. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Figure 1

22 pages, 3733 KiB

Open AccessArticle

Study of Colliding Particle-Pair Velocity Correlation in Homogeneous Isotropic Turbulence

by Santiago Lain, Martin Ernst and Martin Sommerfeld

Appl. Sci. 2020, 10(24), 9095; https://doi.org/10.3390/app10249095 - 19 Dec 2020

Cited by 4 | Viewed by 2691

Abstract

This paper deals with the numerical analysis of the particle inertia and volume fraction effects on colliding particle-pair velocity correlation immersed in an unsteady isotropic homogeneous turbulent flow. Such correlation function is required to build reliable statistical models for inter-particle collisions, in the frame of the Euler–Lagrange approach, to be used in a broad range of two-phase flow applications. Computations of the turbulent flow have been carried out by means of Direct Numerical Simulation (DNS) by the Lattice Boltzmann Method (LBM). Moreover, the dependence of statistical properties of collisions on particle inertia and volumetric fraction is evaluated and quantified. It has been found that collision locations of particles of intermediate inertia,

S t_{K} ~ 1

, occurs in regions where the fluid strain rate and dissipation are higher than the corresponding averaged values at particle positions. Connected with this fact, the average kinetic energy of colliding particles of intermediate inertia (i.e., Stokes number around 1) is lower than the value averaged over all particles. From the study of the particle-pair velocity correlation, it has been demonstrated that the colliding particle-pair velocity correlation function cannot be approximated by the Eulerian particle-pair correlation, obtained by theoretical approaches, as particle separation tends to zero, a fact related with the larger values of the relative radial velocity between colliding particles. Full article

(This article belongs to the Special Issue Fluid Flows Modelling in Microfluidic Systems)

► Show Figures

Journal Menu

Journal Browser

Fluid Flows Modelling in Microfluidic Systems

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Benefits of Publishing in a Special Issue

Published Papers (9 papers)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI