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Protective Effects of Edible and Medicinal Plant Extracts against Oxidative Stress

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 7348

Special Issue Editors

Dr. Katarzyna Kowalska

E-Mail Website
Guest Editor
Department of Biotechnology and Food Microbiology, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-624 Poznan, Poland
Interests: functional foods; antioxidant activity; cell culture; metabolic diseases; apoptosis; molecular biology; biological sciences
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Olejnik

E-Mail Website
Guest Editor
Department of Biotechnology and Food Microbiology, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-624 Poznan, Poland
Interests: functional foods; dietary bioactive compounds; nutrigenomics; antioxidant activity; anticancer potential; chemoprevention; anti-inflammatory effects; obesity; inflammatory bowel disease; endometriosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress caused by imbalanced metabolism and an excess of reactive oxygen species (ROS) leads to a range of health disorders in humans, including diabetes, cardiovascular disease, and cancer. ROS are produced continuously in the body, via oxidative metabolism, mitochondrial bioenergetics, and immune function, which are involved in the progression, growth, death, and differentiation of cells. Various modifiable factors cause oxidative stress; therefore, the use of simple interventions, such as supplementation with plant foods with a high antioxidant compound content, can decrease oxidative stress levels and reduce the incidence of complex diseases. Edible and medicinal plants contain plenty of compounds with antioxidant and anti-inflammatory properties. It is plausible that their sustained consumption might counteract these diseases by reducing oxidative DNA damage, down-regulating oxidative stress, and increasing the expression of genes responsible for DNA repair, cell-cycle control, and anti-inflammatory effects. The Special Issue will publish original research papers and reviews related to edible and medicinal plant antioxidant effects, the mechanisms of action, and health benefits in the prevention and treatment of chronic diseases.

Dr. Katarzyna Kowalska
Dr. Anna Olejnik
Guest Editors

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Keywords

  • oxidative stress
  • antioxidant activity
  • medicinal plants
  • reactive oxygen species
  • phytochemicals
  • antioxidants
  • radical scavenging activities
  • anti-inflammatory
  • health benefits
  • metabolic diseases

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Published Papers (3 papers)

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Research

23 pages, 7108 KiB  
Article
Protective Effects of Aquilaria agallocha and Aquilaria malaccensis Edible Plant Extracts against Lung Cancer, Inflammation, and Oxidative Stress—In Silico and In Vitro Study
by Jinnatun Nahar, Vinothini Boopathi, Esrat Jahan Rupa, Muhammad Awais, Anjali Kariyarath Valappil, Md Niaj Morshed, Mohanapriya Murugesan, Reshmi Akter, Dong Uk Yang, Ramya Mathiyalagan, Deok Chun Yang and Seok-Kyu Jung
Appl. Sci. 2023, 13(10), 6321; https://doi.org/10.3390/app13106321 - 22 May 2023
Cited by 4 | Viewed by 2740
Abstract
The family Thymelaeaceae, which includes huge evergreen trees that are sparsely distributed in tropical rainforests, includes the genus Aquilaria. Numerous medical conditions, including inflammation, cancer, and oxidative stress have been traditionally treated using Aquilaria agallocha and Aquilaria malaccensis. In this study, [...] Read more.
The family Thymelaeaceae, which includes huge evergreen trees that are sparsely distributed in tropical rainforests, includes the genus Aquilaria. Numerous medical conditions, including inflammation, cancer, and oxidative stress have been traditionally treated using Aquilaria agallocha and Aquilaria malaccensis. In this study, we evaluated in silico and biological activity with A. agallocha and A. malaccensis sample for more conformation. Raw 264.7 macrophage cells and HacaT cells were used, together with the MTT, ROS, NO, and wound healing assays, to investigate the possible cytotoxicity in A549 lung cancer. Thus, A. agallocha and A. malaccensis showed significant cytotoxicity against A549 cancer cells at 1000 µg/mL. Furthermore, we observed an elevated ROS level in cancer cells. The wound healing assay showed cancer cell inhibition activity. While BCL-2 decreased in the intrinsic route, p53, Bax, Caspase 3, and Caspase 9 were elevated by A.A and A.M. Additionally, we have also conducted an in silico evaluation followed by molecular dynamics (MD) simulations, along with ADMET and biological activity prediction to further validate the experimental results. In normal cells, both samples showed less toxicity at 1000 µg/mL and suppressed the LPS-treated NO and ROS levels against the inflammation. Additionally, A.A and A.M suppressed the pro-inflammatory gene expression of COX-2, iNOS, TNF-α, IL-6, and IL-8 in RAW 264.7 cells. On the other hand, A.A and A.M extract effectively suppressed oxidative stress by increasing the antioxidative gene expression in H2O2-induced HaCat cells at 50 μg/mL. This study revealed that the plant extracts from A. agallocha and A. malaccensis could exert a cytotoxic effect on lung adenocarcinoma cells through the activation of an intrinsic signaling pathway. Moreover, it could be a potential source of anti-inflammatory, antioxidant, and anti-cancer agents after consideration of in vivo and clinical studies. Full article
(This article belongs to the Special Issue Protective Effects of Edible and Medicinal Plant Extracts against Oxidative Stress)
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9 pages, 286 KiB  
Article
Potential Effect of Syzygium aromaticum (Cloves) Extract on Serum Antioxidant Status and Lipid Profiles in Wistar Rats with Artesunate Toxicity
by Mosebolatan Victoria Adegbola, Godwin Anyim, Monde Ntwasa, Ademola Olabode Ayeleso and Temitope Adenike Oyedepo
Appl. Sci. 2022, 12(16), 8216; https://doi.org/10.3390/app12168216 - 17 Aug 2022
Cited by 5 | Viewed by 1923
Abstract
Artesunate toxicity has been linked to increased production of reactive oxygen species resulting in oxidative stress, which has been implicated in the pathogenesis of many chronic diseases. This study evaluated the effects of hydroethanolic extract of Syzygium aromaticum buds (HESAB) on serum antioxidant [...] Read more.
Artesunate toxicity has been linked to increased production of reactive oxygen species resulting in oxidative stress, which has been implicated in the pathogenesis of many chronic diseases. This study evaluated the effects of hydroethanolic extract of Syzygium aromaticum buds (HESAB) on serum antioxidant status and lipid profiles in Wistar rats with artesunate toxicity. Forty-eight male Wistar rats (150–200 g) randomized into six groups (n = 8) were treated as follows for 21 days: Group 1 (Control; DMSO); Group 2 (Artesunate, 15 mg/kg only); Group 3 (HESAB only, 400 mg/kg); Group 4 (HESAB only, 800 mg/kg); Group 5 (Artesunate, 15 mg/kg + HESAB, 400 mg/kg); Group 6 (Artesunate, 15 mg/kg + HESAB, 800 mg/kg). Antioxidant parameters—such as malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT)—were assayed in the serum using established methods. Serum lipid profiles—which include total cholesterol (TC), triglyceride (TAG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) assays—were performed using kits. The findings showed a significant increase in lipid profile of the artesunate-induced group compared to the control and treated groups. Administration of HESAB reversed the toxic effects of artesunate. The levels of TC (69.42 ± 8.03 mg/dL, TAG (34.43 ± 6.04 mg/dL), and LDL (45.1 ± 9.66 mg/dL) in the untreated group were significantly higher than the control group TC (41.42 ± 7.57 mg/dL), TAG (28.18 ± 1.58 mg/dL), and LDL (27.73 ± 5.00 mg/dL). The antioxidant profile however was significantly reduced in the diseased (artesunate) group compared to control and treated groups. MDA, NO, and GSH levels in the untreated group were 5.032 ± 1.25 µmol/L, 10.65 ± 3.84 µmol/L, and 0.20 ± 0.145 μM respectively and 2.237 ± 0.95 µmol/L, 6.20 ± 2.21 µmol/L, and 0.49 ± 0.068 μM in control group respectively. Treatment with HESAB raised the GSH level to 0.38 ± 0.19 μM. Furthermore, CAT, SOD, and GPX were 7.62 ± 2.15, 2.76 ± 1.52, and 3.54 ± 1.91 μmol/mL in untreated group respectively and 19.03 ± 4.25, 8.05 ± 2.91, and 10.62 ± 3.24 μmol/mL in control group respectively. Treatment with HESAB raised the CAT, SOD, and GPX to 18.866 ± 2.59, 5.020 ± 0.89, and 5.05 ± 2.01 μmol/mL respectively. In conclusion, artesunate toxicity caused a significant increase in lipid profiles and decrease in antioxidant level in the rats’ serum while administration of S. aromaticum bud extract lowered lipid levels and raised the antioxidant status. Full article
(This article belongs to the Special Issue Protective Effects of Edible and Medicinal Plant Extracts against Oxidative Stress)
14 pages, 1406 KiB  
Article
Inhibition of Peroxidation Potential and Protein Oxidative Damage by Metal Mangiferin Complexes
by Alberto J. Nuñez-Selles, Lauro Nuevas-Paz and Gregorio Martínez-Sánchez
Appl. Sci. 2022, 12(4), 2240; https://doi.org/10.3390/app12042240 - 21 Feb 2022
Cited by 1 | Viewed by 1847
Abstract
Background: Metal coordination complexes of polyphenolic compounds have been claimed to have better antioxidant and protection against protein oxidative damage effects than the isolated ligands. Whereas flavonoids have been extensively studied, xanthones such as mangiferin are lacking extensive research. Methods: Cu (II), Zn [...] Read more.
Background: Metal coordination complexes of polyphenolic compounds have been claimed to have better antioxidant and protection against protein oxidative damage effects than the isolated ligands. Whereas flavonoids have been extensively studied, xanthones such as mangiferin are lacking extensive research. Methods: Cu (II), Zn (II), and Se (IV) mangiferin complexes were synthesized with different stoichiometric ratios. Products were isolated by preparative chromatography and subjected to spectral analysis by FT-IR, HPLC-DAD, and HPLC-ESI-MS. The inhibition effects on peroxidation potential and protein oxidative damage were determined for all the metal–MF complexes. Results: Eight metal–MF complexes were isolated. Cu (II)–MF complexes did not improve MF antioxidant/protective effects; Zn (II) complexes (stoichiometric ratio 1:2) antioxidant/protective effects had no significant differences to MF; Zn (II)– and Se (IV)–MF complexes (stoichiometric ratio 1:3) showed the best inhibition effects on peroxidation potential (49.06% and 32.08%, respectively), and on the protection against protein oxidative damage (14.49% and 20.81%, respectively). Conclusions: The antioxidant/protective effects of Se (IV)– and Zn (II)–MF coordination complexes were significantly improved as compared to isolated MF, when the reaction between the metal salt and MF was performed with a stoichiometric ratio 1:3. Full article
(This article belongs to the Special Issue Protective Effects of Edible and Medicinal Plant Extracts against Oxidative Stress)
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