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Applied Sciences
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Natural Phenolic Compounds from Medicinal Herbs—Antibacterial and Anticancer Properties
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Natural Phenolic Compounds from Medicinal Herbs—Antibacterial and Anticancer Properties

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (30 March 2022) | Viewed by 6204

Special Issue Editors

Prof. Dr. Łukasz Kuźma

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Guest Editor
Department of Biology and Pharmaceutical Botany, Chair of Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
Interests: phytochemical analysis; secondary metabolites isolation; chromatographical methods; medicinal plant biotechnology, bioreactors for medicinal plant cultivation
Special Issues, Collections and Topics in MDPI journals
Dr. Katarzyna Sykłowska-Baranek

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Guest Editor
Department of Pharmaceutical Biology and Medicinal Plants Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland
Interests: medicinal plant biotechnology; molecular biotechnology; phytochemical analysis; evaluation of plant extract biological activity
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ewa Skała

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Guest Editor
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
Interests: plant biotechnology; medicinal plants; bioactive compounds; phytochemistry; essential oil; cytotoxic activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The natural phenolic compounds from medicinal herbs are a large group of secondary metabolites, including flavonoids, hydroxycinnamates, hydroxybenzoates, coumarins, xanthones, chalcones, stilbenes, lignins, lignans, and other plant constituents. These phytochemicals, because of their biodiversity and biological activities, such as anti-cancer, pro-apoptotic, and anti-angiogenic effects, are still the focus of many investigations, including in the search for new plant sources rich in phenolic compounds; new phytocompounds belonging to phenolics; and new paths of extraction, isolation, purification, and quantification. An important path for obtaining phytophenolics is in vitro plant cultures, in which numerous treatments (the kind of culture, elicitation, light quality, sucrose concentration, etc.) can be applied to increase the content of phenolic compounds. This Special Issue is focused mainly on original research, as well as review articles that cover the biosynthesis of bioactive phenolic compounds, fractions, and extracts rich in plant phenolics with respect to their antioxidant, cytotoxic, and other interesting activities.

Dr. Łukasz Kuźma
Dr. Katarzyna Sykłowska-Baranek
Prof. Ewa Skała
Guest Editors

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Keywords

  • phenolic acids
  • flavonoids
  • HPLC
  • UHPLC
  • TLC
  • preparative-HPLC
  • semipreparative-HPLC

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Published Papers (2 papers)

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Research

14 pages, 2728 KiB  
Article
Brassinin Enhances Apoptosis in Hepatic Carcinoma by Inducing Reactive Oxygen Species Production and Suppressing the JAK2/STAT3 Pathway
by Peramaiyan Rajendran, Hany Elsawy, Manal Alfwuaires and Azza Sedky
Appl. Sci. 2022, 12(9), 4733; https://doi.org/10.3390/app12094733 - 8 May 2022
Cited by 3 | Viewed by 1888
Abstract
Plants from the family Brassicaceae produce brassinin (BSN), which is an essential indole phytoalexin. BSN can kill certain types of cancer cells. Using hepatocarcinoma (HCC) cells, we examined the molecular mechanisms of BSN. We found that HCC cell growth was suppressed and apoptosis [...] Read more.
Plants from the family Brassicaceae produce brassinin (BSN), which is an essential indole phytoalexin. BSN can kill certain types of cancer cells. Using hepatocarcinoma (HCC) cells, we examined the molecular mechanisms of BSN. We found that HCC cell growth was suppressed and apoptosis was induced by BSN via the downregulation of the JAK/STAT3 pathway. The cytoplasmic latent transcription factor STAT3, belonging to the STAT family, acted as both a signal transducer and an activator and was linked to tumor progression and decreased survival. BSN incubation caused HCC cells to produce reactive oxygen species (ROS). By activating caspase-9/-3 and PARP cleavage, Bcl-2 was reduced, and apoptosis was increased. BSN inhibited constitutive STAT3, JAK2, and Src phosphorylation. The JAK/STAT signaling cascade was confirmed by siRNA silencing STAT3 in HCC cells. BSN also suppressed apoptosis by Z-Val-Ala-Asp-Fluoromethylketone (Z-VAD-FMK), an apoptotic inhibitor. N-acetylcysteine (NAC) inhibited the production of ROS and diminished BSN-induced apoptosis. Our findings suggested that BSN has potential as a treatment for cancer. Full article
(This article belongs to the Special Issue Natural Phenolic Compounds from Medicinal Herbs—Antibacterial and Anticancer Properties)
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9 pages, 969 KiB  
Article
Phytochemical Analysis of Polyphenols in Leaf Extract from Vernonia amygdalina Delile Plant Growing in Uganda
by Jadwiga Nowak, Anna K. Kiss, Charles Wambebe, Esther Katuura and Łukasz Kuźma
Appl. Sci. 2022, 12(2), 912; https://doi.org/10.3390/app12020912 - 17 Jan 2022
Cited by 11 | Viewed by 3562
Abstract
Due to the presence of phytochemicals, plants have been known to be used in the treatment and management of various diseases. Vernonia amygdalina, belonging to the Asteraceae family, is a plant known for its many applications in traditional medicine for various purposes. [...] Read more.
Due to the presence of phytochemicals, plants have been known to be used in the treatment and management of various diseases. Vernonia amygdalina, belonging to the Asteraceae family, is a plant known for its many applications in traditional medicine for various purposes. Previous studies on the methanolic leaf extract of this plant have proved the antibacterial, cytotoxic, anticancer and antioxidant effects indicative of promising therapeutic potentials. In this work, chromatographic and spectroscopic techniques along with high-performance liquid chromatography quantitative analysis were adopted to isolate, identify and quantify polyphenolic compounds in V. amygdalina leaf extract. UHPLC-DAD-ESI-MS/MS and UHPLC-DAD methods were adopted for qualitative and quantitative analysis, respectively. In the case of polyphenol separation, some reference substances were isolated by preparative HPLC. Seven polyphenols were identified and quantified in this study: 5-O-caffeoylquinic acid, luteolin hexoside, 3,4-O-dicaffeoylquinic acid, 1,5-O-dicaffeoylquinic acid, 3,5-O-dicaffeoylquinic acid, 4,5-O-dicaffeoylquinic acid and luteolin dihexoside, with 3,5-O-dicaffeoylquinic acid being isolated in the highest quantity of 27.49 mg g−1 extract. Full article
(This article belongs to the Special Issue Natural Phenolic Compounds from Medicinal Herbs—Antibacterial and Anticancer Properties)
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