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Bioengineering
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Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis 2.0
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Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis 2.0

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 6375

Special Issue Editors

Dr. Ivana Savić Pavičin

E-Mail Website
Guest Editor
Department of Dental Anthropology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Interests: dental anthropology; endodontics; dental stem cells; forensic dentistry; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Dr. Ciro Gargiulo Isacco

E-Mail Website
Guest Editor
Department of Interdisciplinary Medicine, Section of Microbiology and Virology, School of Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
Interests: stem cells; regenerative medicine; tissue engineering; dental disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of the previous release, "Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis"(https://www.mdpi.com/journal/bioengineering/special_issues/Dental_prognosis).

The main aim of this Special Issue, “Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis 2.0”, is to present new and innovative trends and methods used in every aspect of dentistry. Oral health is a very important part of general health. Today, we are witnessing the accelerated development of materials and technology, including those applied in the treatment and general improvement of oral health. Constant progress is necessary to meet the growing demands of the profession and take advantage of the latest knowledge in the field of materials and technology applicable in the dental profession. Regenerative methods and biomaterials are finding increasing use in dental clinical practice. All new knowledge in this field will be a significant and valuable contribution to this Special Issue.

We will be pleased to publish original scientific papers, review papers, and case reports that are related to new and innovative approaches in diagnostic, therapeutic, and prognostic methods in dental medicine, as well as new materials and procedures. Topics of interest for this Special Issue include but are not limited to the following:

  • Investigation and application of new and innovative materials in dentistry.
  • Investigation and application of new, advanced or improved technology in the prevention, diagnosis, and treatment of dental and oral diseases.
  • Biomaterials and regenerative procedures in dentistry.
  • Advanced dental imaging and digital information processing.

Application of artificial intelligence in the dental profession.

Dr. Ivana Savić Pavičin
Dr. Ciro Gargiulo Isacco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (3 papers)

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Research

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11 pages, 3087 KiB  
Article
Gingival Fibroblasts Are Sensitive to Oral Cell Lysates Indicated by Their IL11 Expression
by Layla Panahipour, Azarakhsh Oladzad Abbasabadi and Reinhard Gruber
Bioengineering 2023, 10(10), 1193; https://doi.org/10.3390/bioengineering10101193 - 13 Oct 2023
Cited by 1 | Viewed by 1265
Abstract
Damaged cells that appear as a consequence of invasive dental procedures or in response to dental materials are supposed to release damage-associated signals. These damage-associated signals not only support tissue regeneration but might also contribute to unwanted fibrosis. The aim of this study [...] Read more.
Damaged cells that appear as a consequence of invasive dental procedures or in response to dental materials are supposed to release damage-associated signals. These damage-associated signals not only support tissue regeneration but might also contribute to unwanted fibrosis. The aim of this study was to identify a molecular target that reflects how fibroblasts respond to necrotic oral tissue cells. To simulate the cell damage, we prepared necrotic cell lysates by sonication of the osteocytic cell line IDG-SW3 and exposed them to gingival fibroblasts. RNAseq revealed a moderate increase in IL11 expression in the gingival fibroblasts, a pleiotropic cytokine involved in fibrosis and inflammation, and also in regeneration following trauma. Necrotic lysates of the human squamous carcinoma cell lines HSC2 and TR146, as well as of gingival fibroblasts, however, caused a robust increase in IL11 expression in the gingival fibroblasts. Consistently, immunoassay revealed significantly increased IL11 levels in the gingival fibroblasts when exposed to the respective lysates. Considering that IL11 is a TGF-β target gene, IL11 expression was partially blocked by SB431542, a TGF-β receptor type I kinase inhibitor. Moreover, lysates from the HSC2, TR146, and gingival fibroblasts caused a moderate smad2/3 nuclear translocation in the gingival fibroblasts. Taken together and based on IL11 expression, our findings show that fibroblasts are sensitive to damaged oral tissue cells. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis 2.0)
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13 pages, 3553 KiB  
Article
A Study on the Biofilm Removal Efficacy of a Bioelectric Toothbrush
by Hyun Mok Park, Seungjae Ryu, Eunah Jo, Sun Kook Yoo and Young Wook Kim
Bioengineering 2023, 10(10), 1184; https://doi.org/10.3390/bioengineering10101184 - 13 Oct 2023
Cited by 4 | Viewed by 2253
Abstract
Effective oral care is a critical requirement to maintain a high quality of life. Most oral diseases are caused by plaque (oral biofilm), which is also correlated with systemic diseases. A common method to remove biofilm is brushing teeth with toothpaste. However, 3.5 [...] Read more.
Effective oral care is a critical requirement to maintain a high quality of life. Most oral diseases are caused by plaque (oral biofilm), which is also correlated with systemic diseases. A common method to remove biofilm is brushing teeth with toothpaste. However, 3.5 billion people in the world have oral diseases, meaning that more efficient methods of removing biofilms are needed. We have developed a toothbrush that applies a bioelectric effect (BE) utilizing an electric force for biofilm removal. It demonstrated significantly higher biofilm removal efficiency than non-BE manual toothbrushes. Tests were performed in saline and toothpaste conditions using various pressures. Results showed that the BE toothbrush had a significantly higher biofilm removal efficiency in saline (0.5 N: 215.43 ± 89.92%, 2.5 N: 116.77 ± 47.02%) and in a toothpaste slurry (0.5 N: 104.96 ± 98.93%, 2.5 N: 96.23 ± 35.16%) than non-BE manual toothbrushes. Results also showed that BE toothbrushes were less dependent on toothpaste. This study suggests that the application of BE can be a new solution to plaque problems in oral care. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis 2.0)
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Review

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18 pages, 769 KiB  
Review
State of the Art in the Diagnosis and Assessment of Oral Malignant and Potentially Malignant Disorders: Present Insights and Future Outlook—An Overview
by Dardo Menditti, Mario Santagata, David Guida, Roberta Magliulo, Giovanni Maria D’Antonio, Samuel Staglianò and Ciro Emiliano Boschetti
Bioengineering 2024, 11(3), 228; https://doi.org/10.3390/bioengineering11030228 - 28 Feb 2024
Cited by 1 | Viewed by 2558
Abstract
Oral Potentially Malignant Disorder (OPMD) is a significant concern for clinicians due to the risk of malignant transformation. Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer with a low survival rate, causing over 200,000 new cases globally each year. Despite [...] Read more.
Oral Potentially Malignant Disorder (OPMD) is a significant concern for clinicians due to the risk of malignant transformation. Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer with a low survival rate, causing over 200,000 new cases globally each year. Despite advancements in diagnosis and treatment, the five-year survival rate for OSCC patients remains under 50%. Early diagnosis can greatly improve the chances of survival. Therefore, understanding the development and transformation of OSCC and developing new diagnostic methods is crucial. The field of oral medicine has been advanced by technological and molecular innovations, leading to the integration of new medical technologies into dental practice. This study aims to outline the potential role of non-invasive imaging techniques and molecular signatures for the early detection of Oral Malignant and Potentially Malignant Disorders. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis 2.0)
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