Cognitive Decline and Its Transversality: Potential Mechanisms and Modulators of Disease
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 92
Special Issue Editors
Interests: cognitive impairment; dementia; cognitive functions; genetics and epigenetics
Special Issues, Collections and Topics in MDPI journals
Interests: multiple sclerosis; biomarkers; DMTs; progression; cognitive impairment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cognitive decline represents, in all its clinical manifestations, a challenge in the field of research and a problem for global public health. It can be an expression of neurodegenerative dementing pathologies or contextualized in other pathologies (e.g., multiple sclerosis, cerebrovascular pathologies, infectious, toxic metabolic diseases, etc.). The mechanisms of disease in cognitive impairment are numerous and different depending on the pathologies that underlie it. Among the numerous mechanisms are protein misfolding in forms of neurodegenerative dementia (Alzheimer's disease, frontotemporal lobar degeneration, and Lewy body dementia), neurodegenerative and neuroinflammatory processes (multiple sclerosis), glial cell involvement, and vascular and metabolic involvement (heart–brain axis, gut–brain axis, diabetes, etc.). On the other hand, among the possible modulators, we think of epigenomics, transcriptomics, and therefore micro-RNAs and long non-coding RNAs. Therefore, the primary targets in the face of a decline in cognitive function are:
- Identify the underlying cause through both preclinical (cellular or animal models) and clinical (morphological and functional neuroimaging studies) studies;
- Detect it early through the use of biomarkers;
- Identify modulators of the disease course that could be potential therapeutic targets.
Dr. Cinzia Coppola
Dr. Elisabetta Signoriello
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cognitive decline
- Alzheimer’s disease
- fronto-temporal lobar degeneration
- Lewy body disease
- multiple sclerosis
- protein misfolding
- amyloid
- tauopathy
- neuroinflammation
- microglia
- astroglia
- synaptopathy
- CSF biomarkers
- plasmatic biomarkers
- micro-RNA or miRNA
- long noncoding RNA or lncRNA
- heart–brain axis
- gut–brain axis
- cerebrovascular disease
- hippocampal atrophy
- structural and functional neuroimaging
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
