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Bioengineering
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Biosensors in Biomedical Applications
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Biosensors in Biomedical Applications

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 25227

Special Issue Editor

Dr. Zhaoli Gao

E-Mail Website
Guest Editor
Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China
Interests: biosensor; two-dimensional materials; wearable electronics; point-of-care testing

Special Issue Information

Dear Colleagues,

Recent studies on nanomaterials have led to tremendous opportunities in biosensing applications for early disease diagnosis, point-of-care (POC) testing, and wearable health monitoring. Various organic/inorganic, nano/micromaterials can be tailored to the monitoring complex biological systems with improved sensitivity, limit-of-detection, specificity, reliability, and long-term stability. This Special Issue is dedicated to covering the most recent results and emerging concepts in addressing the current biosensing challenges.

Topics may include, but are not limited to, the following:

  • Advances in nanostructured materials for biosensing applications;
  • Bioelectronic devices for healthcare applications;
  • High-throughput biosensing platforms;
  • Multiplexed sensing systems for POC or wearable applications.

Dr. Zhaoli Gao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • nanomaterials
  • bioelectronics
  • high-throughput sensing
  • multiplexed sensing platform
  • wearable electronics

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Published Papers (5 papers)

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Research

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10 pages, 881 KiB  
Article
Physiological Effect of Deep Pressure in Reducing Anxiety of Children with ASD during Traveling: A Public Transportation Setting
by Ilham Yustar Afif, Aloysius Raynaldo Manik, Kristian Munthe, Mohamad Izzur Maula, Muhammad Imam Ammarullah, Jamari Jamari and Tri Indah Winarni
Bioengineering 2022, 9(4), 157; https://doi.org/10.3390/bioengineering9040157 - 5 Apr 2022
Cited by 35 | Viewed by 5454
Abstract
Traveling with children with autism can be very challenging for parents due to their reactions to sensory stimuli resulting in behavioral problems, which lead to self-injury and danger for themselves and others. Deep pressure was reported to have a calming effect on people [...] Read more.
Traveling with children with autism can be very challenging for parents due to their reactions to sensory stimuli resulting in behavioral problems, which lead to self-injury and danger for themselves and others. Deep pressure was reported to have a calming effect on people with autism. This study was designed to investigate the physiological effect of deep pressure, which is an autism hug machine portable seat (AHMPS) in children with autism spectrum disorders (ASD) in public transportation settings. The study was conducted with 20 children with ASD (16 boys and 4 girls) at the Semarang Public Special School with an age ranging from 4 to 13 years (mean 10.9 ± 2.26 years), who were randomly assigned into two groups. The experiment consisted of group I who used the AHMPS inflatable wraps model and group II who used the AHMPS manual pull model. Heart rate (HR) and skin conductance (SC) were analyzed to measure the physiological calming effect using pulse oximeter oximetry and a galvanic skin response (GSR) sensor. Heart rate was significantly decreased during the treatment compared to the baseline (pre-test) session in group I (inflating wrap model) with p = 0.019, while no change of heart rate variability (HRV) was found in group II (manual pull model) with p = 0.111. There was no remaining effect of deep pressure using the HRV indicator after the treatment in both groups (group I with p = 0.159 and group II with p = 0.566). GSR captured the significant decrease in skin conductance during the treatment with p < 0.0001 in group I, but no significant decrease was recorded in group II with p = 0.062. A skin conductance indicator captured the remaining effect of deep pressure (after the treatment); it was better in group I (p = 0.003) than in group II (p = 0.773). In conclusion, the deep pressure of the AHMPS inflating wrap decreases physiological arousal in children with ASD during traveling. Full article
(This article belongs to the Special Issue Biosensors in Biomedical Applications)
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8 pages, 1132 KiB  
Article
Effects of Jump-Rope-Specific Footwear Selection on Lower Extremity Biomechanics
by Hai-Bin Yu, Jing Li, Rui Zhang, Wei-Ya Hao, Jian-Zhi Lin and Wei-Hsun Tai
Bioengineering 2022, 9(4), 135; https://doi.org/10.3390/bioengineering9040135 - 24 Mar 2022
Cited by 7 | Viewed by 3552
Abstract
Footwear is among the most important equipment in sports to decrease injuries and enhance performance during exercise. In this study, we investigated differences in lower extremity plantar pressure and muscle activations during jump rope activities. Ten participants performed jump rope under two landing [...] Read more.
Footwear is among the most important equipment in sports to decrease injuries and enhance performance during exercise. In this study, we investigated differences in lower extremity plantar pressure and muscle activations during jump rope activities. Ten participants performed jump rope under two landing conditions with different footwear. A force platform (AMTI, 1000 Hz), a Novel Pedar-X system (Nove, 100 Hz), and a wireless electromyography (EMG) system (Noraxon, 1500 Hz) were used to measure biomechanical parameters during the jump rope exercise. Vertical ground reaction forces (vGRF), plantar pressure, and lower extremity muscle activations were analyzed. One-leg landing resulted in a significantly greater vGRF and shorter fly time than two-leg landing (p < 0.05). A significantly higher peak pressure and lesser toe (LT) area pressure was shown with the jumping shoe (all p < 0.05), but lower plantar pressure resulted in the middle foot area (p < 0.05). The EMG results of tibialis anterior (TA) were significantly greater with one-leg landing (all p < 0.05) during the pre- and background activity (BGA) phases. The results suggest that plantar pressure distribution should be considered when deciding on footwear during jump rope exercises, but care should be taken with regards to recovery after repeated collisions and fatigue. The jumping shoe provides benefits in terms of decreased plantar pressure sustained during jump rope exercises. Full article
(This article belongs to the Special Issue Biosensors in Biomedical Applications)
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10 pages, 1562 KiB  
Article
Effect of Short-Term Deep-Pressure Portable Seat on Behavioral and Biological Stress in Children with Autism Spectrum Disorders: A Pilot Study
by Ilham Yustar Afif, Muhammad Farkhan, Ojo Kurdi, Mohamad Izzur Maula, Muhammad Imam Ammarullah, Budi Setiyana, J. Jamari and Tri Indah Winarni
Bioengineering 2022, 9(2), 48; https://doi.org/10.3390/bioengineering9020048 - 20 Jan 2022
Cited by 37 | Viewed by 6845
Abstract
Children with autism spectrum disorder (ASD) have challenging behaviors, which are associated with difficulties in parenting. Deep pressure is a therapeutic modality in occupational therapy, and it was reported to produce a calming effect. This study aimed to determine whether the short-term use [...] Read more.
Children with autism spectrum disorder (ASD) have challenging behaviors, which are associated with difficulties in parenting. Deep pressure is a therapeutic modality in occupational therapy, and it was reported to produce a calming effect. This study aimed to determine whether the short-term use of an autism hug machine portable seat (AHMPS) improves behavioral and neurobiological stress in children with ASD, and to determine whether AHMPS with an inflatable wrap or manual pull is more effective. This study enrolled children with ASD who were administered with the inflatable wrap (group I) and manual pull (group II) for 20 min twice a week for 3 weeks. Conners’ Parent Rating Scale-48 (CPRS-48) was used to rate behavioral improvements, and galvanic skin response (GSR) was used to measure sympathetic stress response. A total of 20 children with ASD (14 boys and 6 girls; aged 7–13 years) were included. CPRS-48 presented conduct problems: behavior was significantly decreased in the inflatable group (p = 0.007) compared to the manual pull group. The GSR captured a significant reduction in sympathetic response (p = 0.01) only in group I. Neurobiological stress was reduced in children who were wearing the AHMPS inflatable wrap; therefore, AHMPS inflatable wrap is an effective method to reduce emotional arousal. Full article
(This article belongs to the Special Issue Biosensors in Biomedical Applications)
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11 pages, 3743 KiB  
Article
Versatile Covalent Postsynthetic Modification of Metal Organic Frameworks via Thermal Condensation for Fluoride Sensing in Waters
by Eugenio Hernan Otal, Manuela Leticia Kim, Yoshiyuki Hattori, Yu Kitazawa, Juan Paulo Hinestroza and Mutsumi Kimura
Bioengineering 2021, 8(12), 196; https://doi.org/10.3390/bioengineering8120196 - 29 Nov 2021
Cited by 3 | Viewed by 2909
Abstract
Having access to safe drinking water is one of the 17 sustainable development goals defined by the United Nations (UN). However, many settlements around the globe have limited access to drinkable water due to non-anthropogenic pollution of the water sources. One of those [...] Read more.
Having access to safe drinking water is one of the 17 sustainable development goals defined by the United Nations (UN). However, many settlements around the globe have limited access to drinkable water due to non-anthropogenic pollution of the water sources. One of those pollutants is fluoride, which can induce major health problems. In this manuscript, we report on a post synthetic functionalization of metal organic frameworks for the sensing of fluoride in water. The proposed thermal condensation methodology allows for a high yield of functionalization using few steps, reducing reagent costs and generating minimal by-products. We identified a Rhodamine B functionalized Al-BDC-NH2 metal organic framework as one particularly suitable for fluoride detection in water. Full article
(This article belongs to the Special Issue Biosensors in Biomedical Applications)
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Review

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22 pages, 2861 KiB  
Review
Smartphone-Based Biosensor Devices for Healthcare: Technologies, Trends, and Adoption by End-Users
by Rossana E. Madrid, Fernando Ashur Ramallo, Daniela E. Barraza and Roberto E. Chaile
Bioengineering 2022, 9(3), 101; https://doi.org/10.3390/bioengineering9030101 - 1 Mar 2022
Cited by 34 | Viewed by 5189
Abstract
Smart biosensors are becoming an important support for modern healthcare, even more so in the current context. Numerous smartphone-based biosensor developments were published in recent years, some highly effective and sensitive. However, when patents and patent applications related to smart biosensors for healthcare [...] Read more.
Smart biosensors are becoming an important support for modern healthcare, even more so in the current context. Numerous smartphone-based biosensor developments were published in recent years, some highly effective and sensitive. However, when patents and patent applications related to smart biosensors for healthcare applications are analyzed, it is surprising to note that, after significant growth in the first half of the decade, the number of applications filed has decreased considerably in recent years. There can be many causes of this effect. In this review, we present the state of the art of different types of smartphone-based biosensors, considering their stages of development. In the second part, a critical analysis of the possible reasons why many technologies do not reach the market is presented. Both technical and end-user adoption limitations were addressed. It was observed that smart biosensors on the commercial stage are still scarce despite the great evolution that these technologies have experienced, which shows the need to strengthen the stages of transfer, application, and adoption of technologies by end-users. Full article
(This article belongs to the Special Issue Biosensors in Biomedical Applications)
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