10th Anniversary of Biology: Cyclic Nucleotide Signaling

Dear Colleagues,

The year 2021 marks the 10th anniversary of Biology, a peer-reviewed open access journal on biological sciences. Biology has published more than 1200 papers from more than 8300 authors. We are grateful to every author, reviewer, and academic editor whose support has made us where we are today.

To mark this significant milestone, a Special Issue entitled “10th Anniversary of Biology: Cyclic Nucleotide Signaling” is being launched. Since their discovery in the 1970s, cyclic nucleotides have been shown to serve as critical signalling molecules across all branches of life. In procaryotes, cAMP plays vital roles in the regulation of virulence and catabolite repression, whereas in fungi, cyclic nucleotides are involved in the regulation of sexual development, differentiation, and response to stress. In vertebrates, cyclic nucleotides act as second messengers that transduce the action of a myriad of extracellular signals, ranging from hormones and neurotransmitters, to proton concentration or light, into the appropriate cellular responses, and thereby impact essentially all cellular and physiologic functions from the beginning of life (fertilization) to the end of life (cellular apoptosis and death). Despite major advances, much remains to be learned, as illustrated by the recent discovery of important roles for novel, non-canonical cyclic nucleotides (such as cUMP), or the discovery of novel cyclic nucleotide effector proteins (such as Popeye domain-containing proteins (POPDC)). Furthermore, we are just beginning to answer some of the major questions and enigmas in the field, such as how production of the same second messenger (e.g. cAMP) can accurately transduce the action of a multitude of extracellular signals that act on the same cell into the appropriate cellular responses.

This Special Issue welcomes original research, short communications, and review manuscripts broadly related to cyclic nucleotide signalling, ranging from historical perspectives to reports of recent advances, from basic mechanistic insights to novel critical functions in health and disease, and from the canonical cyclic nucleotides, cAMP and cGMP, to the more recently discovered non-canonical cyclic nucleotides.

Dr. Wito Richter
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cyclic nucleotide signaling
• cAMP
• cGMP
• compartmentalization
• cyclases
• phosphodiesterases
• PDE
• effector proteins
• physiologic and pathologic states
• inhibitor/drug development