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Biomedicines
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Advances in Cardiovascular Pharmacology: The Era of Targeted Therapies in...
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Advances in Cardiovascular Pharmacology: The Era of Targeted Therapies in Cardiology 3.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4504

Special Issue Editors

Prof. Dr. Pietro Scicchitano

E-Mail Website
Guest Editor
Cardiology Department, Perinei Hospital, Bari, Italy
Interests: noninvasive assessment; heart failure; arrhythmias; preventive cardiology; cardiovascular pharmacology; cardio-oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Francesco Massari

E-Mail Website
Guest Editor
Cardiology Department, Perinei Hospital, Bari, Italy
Interests: heart failure; cardiomyopathies; cardiac physiology; cardiorenal syndrome; cardiovascular pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Despite primary and secondary prevention protocols, the mortality and morbidity rates still remain higher (about 4–17%).

Recently, pharmacological industries have introduced new drugs which have been demonstrated to dramatically impact residual atherothrombotic risk and positively influence the outcome of invalidating pathologies, such as heart failure.

Specifically, cardiovascular pharmacology is now facing a new approach to cardiac diseases: the molecular “influence” of gene transcription and transduction in order to target the inner mechanism which could be responsible for the onset and progression of CVDs.

Recent innovations in the field of non-invasive treatment of CVDs are focusing on three main issues: 1. specifically identifying and treating the core cause of the illness; 2. avoiding adverse events related to pharmacological treatments; 3. improving adherence to and persistence on therapies.

The aim of this Special Issue is to provide a dedicated overview of new pharmacological approaches to CVDs.

Authors are invited to contribute original basic research, prospective studies, and systematic reviews in the field of pharmacological approaches to cardiac and vascular diseases by outlining the most recent advances in therapies and treatments.

Dr. Pietro Scicchitano
Dr. Francesco Massari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular pharmacology
  • target-therapy
  • siRNA
  • lipid management
  • heart failure
  • prognosis

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Published Papers (2 papers)

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Research

11 pages, 1846 KiB  
Article
The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats
by Sania Munir, Rizwan Hafeez, Waqas Younis, Muhammad Nasir Hayat Malik, Muhammad Usman Munir, Wajiha Manzoor, Muryam Abdul Razzaq, Luciane Barbosa Pessoa, Katiana Simões Lopes, Francislaine Aparecida dos Reis Lívero and Arquimedes Gasparotto Junior
Biomedicines 2023, 11(10), 2820; https://doi.org/10.3390/biomedicines11102820 - 18 Oct 2023
Cited by 5 | Viewed by 2115
Abstract
Citronellol has been reported to have anti-inflammatory, anti-cancer, and antihypertensive activities, but its effect on myocardial ischemia is still unclear. The aim of this study was to investigate the therapeutic effects and pharmacological mechanisms of citronellol on ischemia. Therefore, a rat model of [...] Read more.
Citronellol has been reported to have anti-inflammatory, anti-cancer, and antihypertensive activities, but its effect on myocardial ischemia is still unclear. The aim of this study was to investigate the therapeutic effects and pharmacological mechanisms of citronellol on ischemia. Therefore, a rat model of myocardial ischemia was established using the doxorubicin (DOX) model. To induce cardiotoxicity, the rats were given DOX (2.5 mg/kg) intraperitoneally over a 14-day period. Group I served as the control and received tween 80 (0.2%), group II received the vehicle and DOX, group III received the standard drug dexrazoxane and DOX, whereas groups IV, V, and VI were treated orally with citronellol (25, 50, and 100 mg/kg) and DOX, respectively. After treatment, the rats were euthanized, and blood samples were collected to assess the levels of serum cardiac markers, lipid profiles, and tissue antioxidant enzymes. The gene expressions of eNOS, PPAR-g, IL-10, VEGF, and NFkB-1 were also determined using real-time polymerase chain reactions. Simultaneous treatment with DOX and citronellol reduced cardiac antioxidant enzymes and lipid biomarkers in a dose-dependent manner. Citronellol also increased the expression of anti-inflammatory cytokines while reducing the expression of pro-inflammatory cytokines. Therefore, it can be concluded that citronellol may have potential cardioprotective effects in preventing DOX-induced cardiotoxicity. Full article
(This article belongs to the Special Issue Advances in Cardiovascular Pharmacology: The Era of Targeted Therapies in Cardiology 3.0)
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24 pages, 14632 KiB  
Article
Neuroprotective and Cardiometabolic Role of Vitamin E: Alleviating Neuroinflammation and Metabolic Disturbance Induced by AlCl3 in Rat Models
by Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash, Ahmed Nadeem and Tahir Maqbool Mir
Biomedicines 2023, 11(9), 2453; https://doi.org/10.3390/biomedicines11092453 - 4 Sep 2023
Cited by 3 | Viewed by 1771
Abstract
Cardiovascular diseases (CVDs) and neurodegenerative disorders, such as diabetes mellitus and Alzheimer’s disease, share a common pathophysiological link involving insulin resistance (IR), inflammation, and hypertension. Aluminium chloride (AlCl3), a known neurotoxicant, has been associated with neurodegeneration, cognitive impairment, and various organ [...] Read more.
Cardiovascular diseases (CVDs) and neurodegenerative disorders, such as diabetes mellitus and Alzheimer’s disease, share a common pathophysiological link involving insulin resistance (IR), inflammation, and hypertension. Aluminium chloride (AlCl3), a known neurotoxicant, has been associated with neurodegeneration, cognitive impairment, and various organ dysfunctions due to the production of reactive oxygen species (ROS) and oxidative stress. In this study, we aimed to investigate the potential protective effects of metformin and vitamin E against AlCl3-induced neuroinflammation and cardiometabolic disturbances in rat models. Rats were divided into five groups: a normal control group, an AlCl3-treated diseased group without any treatment, and three groups exposed to AlCl3 and subsequently administered with metformin (100 mg/kg/day) alone, vitamin E (150 mg/kg/day) orally alone, or a combination of metformin (100 mg/kg/day) and vitamin E (150 mg/kg/day) for 45 days. We analyzed serum biomarkers and histopathological changes in brain, heart, and pancreatic tissues using H&E and Masson’s trichrome staining and immunohistochemistry (IHC). Electrocardiogram (ECG) patterns were observed for all groups. The AlCl3-treated group showed elevated levels of inflammatory biomarkers, MDA, and disturbances in glycemic and lipid profiles, along with reduced insulin levels. However, treatment with the combination of metformin and vitamin E resulted in significantly reduced glucose, cholesterol, LDL, and TG levels, accompanied by increased insulin and HDL levels compared to the individual treatment groups. Histopathological analyses revealed that combination therapy preserved neuronal structures, muscle cell nuclei, and normal morphology in the brain, heart, and pancreatic tissues. IHC demonstrated reduced amyloid plaques and neurofibrillary tangles in the combination-treated group compared to the AlCl3-treated group. Moreover, the combination group showed a normal ECG pattern, contrasting the altered pattern observed in the AlCl3-treated group. Overall, our findings suggest that metformin and vitamin E, in combination, possess neuroprotective and cardiometabolic effects, alleviating AlCl3-induced neuroinflammation and metabolic disturbances. Full article
(This article belongs to the Special Issue Advances in Cardiovascular Pharmacology: The Era of Targeted Therapies in Cardiology 3.0)
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