Pluripotent Stem Cells: Current Understanding and Future Directions—2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 30 June 2025
Special Issue Editor
Interests: induced pluripotent stem cells; mesenchymal stem cells; transplant immunology; autoimmunity; peripheral nerve regeneration; vascularized composite allotransplantation; cell therapy; exosome therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, “Pluripotent Stem Cells: Current Understanding and Future Directions—2nd Edition”, will focus on induced pluripotent stem cells (iPSCs) and potential therapeutic applications for their derivatives.
Induced pluripotent stem cells can be generated by reprogramming somatic cells using the delivery of exogenous pluripotent factors such as Oct4, Sox2, Nanog, and Klf4. The delivery methods for pluripotent transgenes include genomic integrated strategies, such as lentivirus or retrovirus transduction, and non-genomic integrated strategies, such as episomal plasmid transfection, adenovirus transduction, mRNA transfection, or Sendai virus transduction. The overexpression of these pluripotent factors makes somatic cells undergo transformation into pluripotent stem cells through the obtainment of a round morphology, multilineage differentiation abilities, and self-renewal properties. Therefore, iPSCs are similar to embryonic stem cells (ESCs) in that they possess similar regenerative abilities and can differentiate into any cell type in the body, whereas iPSC generation does not face the ethical controversies related to ESC sources. The therapeutic applications of autologous iPSCs hold great promise in tissue engineering and regenerative and personalized medicine. iPSC-differentiated cells may have the potential to be applied to disease cures or the screening of new drugs. Moreover, allogeneic iPSC-derived exosomes (iPSCs-Exos) act as a form of cell-free therapy and may have broad application prospects in disease treatments.
We invite authors in this field to submit original research or review articles related to the important and rapidly progressing field of iPSC-associated medicine.
Dr. Aline Yen Ling Wang
Guest Editor
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Keywords
- induced pluripotent stem cells
- iPSC generation
- somatic reprogramming
- iPSC-derived cells
- cell therapy
- exosome therapy
- therapeutic application
- drug screening
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