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Biomedicines
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Periodontal Inflammation, Periodontal Disease and Systemic Diseases
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Periodontal Inflammation, Periodontal Disease and Systemic Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 4652

Special Issue Editor

Dr. Oelisoa Mireille Andriankaja

E-Mail Website
Guest Editor
Center for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY, USA
Interests: periodontal disease; periodontitis

Special Issue Information

Dear Colleagues,

Periodontal disease, which is a bacterial-induced infection that may lead to long-lasting oral inflammation, affects the soft connective tissue and supporting bone. The imbalance between periodontal pathogens and the immune and inflammatory responses of the host to the pathogens can explain chronic periodontal tissue destruction.

Besides the extensive studies of the relationships between periodontal disease, type 2 diabetes, and CVD, recent epidemiological studies have suggested an association between periodontal disease and many other systemic inflammatory diseases/disorders, including adverse pregnancy outcomes, rheumatoid arthritis, inflammatory bowel disease (IBD), Alzheimer’s disease, non-alcoholic fatty liver disease, certain cancers, and COVID-19. Most studies highlighted that periodontal disease as a risk factor for these systemic diseases/disorders, but few have assessed the reverse direction, i.e., that systemic diseases/disorders are risk factors for periodontal disease development or progression, while some authors suggested that a bi-directional relationship exists. Periodontal and systemic diseases may share underlying common biological pathways, the exacerbation of which may lead to the occurrence or co-occurrence of either or both health outcomes. These health conditions often occur in the same individuals, revealing a co-morbid condition, and they may act independently or adversely affect each other. However, the underlying mechanism pathways explaining the link between Periodontal disease and systemic comorbidities are still largely unknown. Understanding whether the link is simply a correlative one driven by causal mechanistic interactions is crucial to the diagnosis and treatment of these diseases.

For this Special Issue, we invite authors to submit articles focusing on the study of potential biological mechanisms related to the link between any systemic comorbid diseases/disorders and periodontal disease development. The topic also involve a mechanism of action driving the host-mediated tissue injury via its immune response to periodontal pathogens and related metabolic products and inflammation, which may interdependently play important roles in chronic periodontal tissue destruction.

Dr. Oelisoa Mireille Andriankaja
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal disease
  • periodontitis
  • systemic diseases
  • biological mechanisms
  • correlation
  • inflammation
  • immune response
  • therapeutic targets

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Published Papers (3 papers)

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Research

17 pages, 2335 KiB  
Article
The Association of Chronic Periodontitis as a Potential Risk Factor with Rheumatoid Arthritis: A Nested Case-Control Study Using a Korean National Health Screening Cohort
by Ho Suk Kang, Joo-Hee Kim, Ji Hee Kim, Woo Jin Bang, Hyo Geun Choi, Dae Myoung Yoo, Na-Eun Lee, Kyeong Min Han, Nan Young Kim, Ha Young Park, Kyueng-Whan Min and Mi Jung Kwon
Biomedicines 2024, 12(5), 936; https://doi.org/10.3390/biomedicines12050936 - 23 Apr 2024
Viewed by 1212
Abstract
Growing research has proposed that rheumatoid arthritis (RA) and chronic periodontitis (CP) share similar pathophysiological mechanisms involving inflammation and tissue destruction. However, the potential correlation of CP as a contributing factor for the occurrence of RA warrants validation in the Korean population, where [...] Read more.
Growing research has proposed that rheumatoid arthritis (RA) and chronic periodontitis (CP) share similar pathophysiological mechanisms involving inflammation and tissue destruction. However, the potential correlation of CP as a contributing factor for the occurrence of RA warrants validation in the Korean population, where both diseases are prevalent, especially considering the increasingly aging demographic in Korea. This study examined 5139 RA cases and 509,727 matched controls from a Korean national cohort dataset (2002–2019) by carefully employing propensity score matching to ensure comparability between groups. Baseline characteristics were compared using standardized differences, and logistic regression was employed to estimate the impact of CP history on RA likelihood while controlling for covariates. We fully examined medical records documenting CP occurrences within the two-year period leading up to the index date, conducting comprehensive subgroup analyses. While a 1-year history of CP did not show a significant association with likelihood of RA, a 2-year history of CP increased RA likelihood by 12%, particularly among older adults, females, rural residents, and those with certain comorbidities such as hypercholesterolemia. Interestingly, this association persisted even among individuals with non-smoking habits, normal weight, and infrequent alcohol consumption. These findings suggest that chronic CP exposure for at least 2 years may independently elevate RA risk in Korean adults. The association in certain subgroups appears to suggest a predisposition toward genetic susceptibilities over lifestyle and environmental factors. Predicting RA in CP patients may be challenging, emphasizing the importance of regular RA screening, especially in high-risk subgroups. Full article
(This article belongs to the Special Issue Periodontal Inflammation, Periodontal Disease and Systemic Diseases)
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14 pages, 2701 KiB  
Article
Investigating the Connection between Chronic Periodontitis and Parkinson’s Disease: Findings from a Korean National Cohort Study
by Na-Eun Lee, Dae Myoung Yoo, Kyeong Min Han, Ho Suk Kang, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Hyo Geun Choi, Nan Young Kim, Ha Young Park and Mi Jung Kwon
Biomedicines 2024, 12(4), 792; https://doi.org/10.3390/biomedicines12040792 - 3 Apr 2024
Cited by 2 | Viewed by 1432
Abstract
Recent research suggests a potential relevance between chronic periodontitis (CP) and Parkinson’s disease (PD), raising concerns about comorbid PD among elderly CP patients. However, the epidemiologic basis for this association remains unclear. Employing a nested case-control design, this study explored the association between [...] Read more.
Recent research suggests a potential relevance between chronic periodontitis (CP) and Parkinson’s disease (PD), raising concerns about comorbid PD among elderly CP patients. However, the epidemiologic basis for this association remains unclear. Employing a nested case-control design, this study explored the association between CP and subsequent PD occurrences in Korean adults, leveraging a validated national population-based dataset covering the period from 2002 to 2019. It included 8794 PD patients and 35,176 matched control individuals, established through propensity score matching for age, sex, residential area, and income. Baseline characteristics were compared using standardized differences, and logistic regression was employed to assess the impact of CP histories on PD likelihood while controlling for covariates. We performed a thorough examination of CP events within both 1-year and 2-year intervals preceding the index date, incorporating subgroup analyses. Our analysis revealed no statistically significant association between CP history and PD development overall. However, subgroup analysis revealed a slightly increased likelihood of PD development among CP individuals with a high disease burden (Charlson Comorbidity Index score ≥ 2). In conclusion, although our study did not find a significant overall association between CP history and PD development, the elevated likelihood of PD in subgroups with high disease burden may suggest that comorbidities influence PD probability among certain CP patients. Considering comorbid conditions in PD screening for some individuals with CP may be also important. Full article
(This article belongs to the Special Issue Periodontal Inflammation, Periodontal Disease and Systemic Diseases)
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15 pages, 720 KiB  
Article
Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus
by Oelisoa M. Andriankaja, Reuben Adatorwovor, Alpdogan Kantarci, Hatice Hasturk, Luciana Shaddox and Michael A. Levine
Biomedicines 2023, 11(10), 2770; https://doi.org/10.3390/biomedicines11102770 - 12 Oct 2023
Cited by 4 | Viewed by 1500
Abstract
Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with T2DM [...] Read more.
Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with T2DM aged 40–65 years. The exposures included serum inflammatory mediators (IL-1b, IL-6, IL-10, and TNF-α), endothelial adhesion molecules, RANKL levels, and the GCF content of these analytes from a subset of 158 samples. The outcomes included the percent of sites with a probing pocket depth (PPD) ≥ 4 mm and clinical attachment loss ≥ 4 mm. Adjusted logistic regression models were fit to the categorized outcomes. Results: Increased serum IL-10 (Adj. OR: 1.10, p = 0.04), sICAM-1 (Adj. OR: 1.01; p = 0.06), and elevated serum IL-1β (Adj. OR: 1.93; p = 0.06) were statistically significant or close to being significantly associated with a percent of sites with PPD ≥ 4 mm. An increase in GCF IL-1α (Adj. OR: 1.16; p < 0.01) and IL-1β (Adj: 2.40; p = 0.02) was associated with periodontal parameters. Conclusions: Our findings suggested that oral and systemic endothelial and inflammatory mediators are associated with periodontal clinical parameters among Hispanic adults with T2DM. Full article
(This article belongs to the Special Issue Periodontal Inflammation, Periodontal Disease and Systemic Diseases)
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